Urine L-selectin reflects clinical and histological renal disease activity and treatment response in lupus nephritis across multi-ethnicity [PDF]
Frontiers in Immunology, 2023 ObjectiveThere is an urgent need for novel biomarkers in lupus nephritis (LN). We report a non-invasive urinary biomarker, L-selectin, in two independent multi-ethnic cohorts.MethodsuL-selectin was tested cross-sectionally in a Chinese cohort (n=255) and
Yiwei Shen +23 more
doaj +2 more sources
Serine Phosphorylation of L-Selectin Regulates ERM Binding, Clustering, and Monocyte Protrusion in Transendothelial Migration [PDF]
Frontiers in Immunology, 2019 The migration of circulating leukocytes toward damaged tissue is absolutely fundamental to the inflammatory response, and transendothelial migration (TEM) describes the first cellular barrier that is breached in this process.
Abigail Newe +9 more
doaj +2 more sources
Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression [PDF]
iScience, 2020 Summary: Tetraspanins regulate key processes in immune cells; however, the function of the leukocyte-restricted tetraspanin CD53 is unknown. Here we show that CD53 is essential for lymphocyte recirculation.
Maria C. Demaria +17 more
doaj +2 more sources
L-selectin-dependent and -independent homing of naïve lymphocytes through the lung draining lymph node support T cell response to pulmonary Mycobacterium tuberculosis infection. [PDF]
PLoS Pathogens, 2023 Recruiting large numbers of naïve lymphocytes to lymph nodes is critical for mounting an effective adaptive immune response. While most naïve lymphocytes utilize homing molecule L-selectin to enter lymph nodes, some circulating cells can traffic to the ...
Lina Daniel +5 more
doaj +2 more sources
A cell-extrinsic ligand acquired by activated T cells in lymph node can bridge L-selectin and P-selectin. [PDF]
PLoS ONE, 2018 P-selectin expressed on activated endothelia and platelets supports recruitment of leukocytes expressing P-selectin ligand to sites of inflammation.
Douglas A Carlow +2 more
doaj +2 more sources
Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface [PDF]
Journal of Nanobiotechnology, 2021 Background Sialyl-Lewis X/L-selectin high affinity binding interactions between transmembrane O-glycosylated mucins proteins and the embryo have been implicated in implantation processes within the human reproductive system.
Lewis W. Francis +13 more
doaj +2 more sources
Pak1 Kinase Promotes Activated T Cell Trafficking by Regulating the Expression of L-Selectin and CCR7 [PDF]
Frontiers in Immunology, 2019 Normal function of the adaptive immune system requires trafficking of T cells between the blood and lymphoid organs. Lymphocyte homing to lymph nodes requires that they cross endothelial barriers present in blood vessels and lymphatics.
Ana Dios-Esponera +4 more
doaj +2 more sources
HIV-1 targets L-selectin for adhesion and induces its shedding for viral release [PDF]
Nature Communications, 2018 HIV binding is mediated via CD4 and chemokine co-receptors, but this does not explain the preferential infection of central memory CD4+ T cells. Here the authors show HIV targets L-selectin, induces shedding from the infected cell, and inhibition of L ...
Joseph Kononchik +15 more
doaj +2 more sources
Hypotonicity induces L-selectin shedding in human neutrophils [PDF]
American Journal of Physiology-Cell Physiology, 2001 Expression levels of adhesion molecules on neutrophils are affected under various conditions, including ischemia, possibly because of associated increases in cell volume. We examined the effects of cell swelling in hypotonic media on the level of L-selectin (CD62L) and β2-integrin (CD18) on human neutrophils.
N.K. Kaba, Philip A. Knauf
openalex +3 more sources
L-selectin Promotes Migration, Invasion and Inflammatory Response of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis via NF-kB Signaling Pathway. [PDF]
InflammationWu W, Cheng Z, Nan Y, Pan G, Wang Y.
europepmc +3 more sources