Plasma soluble L-selectin in medicated patients with schizophrenia and healthy controls. [PDF]
PLoS ONE, 2017 Immune dysfunction has been implicated in the pathophysiology of schizophrenia. Leukocyte migration to the site of inflammation is a fundamental step of immune response which involves P-, E-, and L-selectins.
Satyajit Mohite +10 more
doaj +2 more sources
Testosterone Decreases the Number of Implanting Embryos, Expression of Pinopode and L-selectin Ligand (MECA-79) in the Endometrium of Early Pregnant Rats. [PDF]
Int J Environ Res Public Health, 2020 Mokhtar MH, Giribabu N, Salleh N.
europepmc +3 more sources
Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. [PDF]
PLoS ONE, 2017 A growing body of evidence suggests that L-selectin ligands presented on circulating tumor cells facilitate metastasis by binding L-selectin presented on leukocytes. Commonly used methods for detecting L-selectin ligands on tissues, e.g., immunostaining,
Grady E Carlson +6 more
doaj +1 more source
Synthetic Glycoprotein Mimics Inhibit L-Selectin-Mediated Rolling and Promote L-Selectin Shedding [PDF]
Chemistry & Biology, 2004 L-selectin is a leukocyte cell-surface protein that facilitates the rolling of leukocytes along the endothelium, a process that leads to leukocyte migration to a site of infection. Preventing L-selectin-mediated rolling minimizes leukocyte adhesion and extravasation; therefore, compounds that inhibit rolling may act as anti-inflammatory agents.
Mowery, Patricia +6 more
openaire +3 more sources
Calmodulin adopts an extended conformation when interacting with L-selectin in membranes. [PDF]
PLoS ONE, 2013 Calmodulin, an intracellular calcium-binding protein, is thought to regulate ectodomain shedding of many membrane proteins, but the underlying molecular mechanism has remained unclear.
Wei Deng, John A Putkey, Renhao Li
doaj +1 more source
The Cytoplasmic Domain of L-Selectin Participates in Regulating L-Selectin Endoproteolysis [PDF]
The Journal of Immunology, 2001 Abstract Neutrophil recruitment at sites of inflammation is regulated by a series of adhesion and activation events. L-selectin (CD62L) is a leukocyte expressed adhesion protein that is important for neutrophil accumulation and rolling along the vascular endothelium.
E, Matala +3 more
openaire +2 more sources
Transcriptional regulation of mouse l-selectin [PDF]
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2009 L-selectin mediates the initial tethering and rolling of lymphocytes in high endothelial venules. To study the transcriptional regulation of mouse L-selectin, we cloned 4.5 kb 5'-flanking sequences of the mouse sell. Luciferase analysis of serial 5'-deletion mutants showed that the first 285 bp was sufficient to drive high promoter activity in EL4 ...
Xitong, Dang +2 more
openaire +2 more sources
L-Selectin Shedding Regulates Leukocyte Recruitment [PDF]
The Journal of Experimental Medicine, 2001 The physiologic role of L-selectin shedding is unknown. Here, we investigate the effect of L-selectin shedding on firm adhesion and transmigration. In a tumor necrosis factor α–induced model of inflammation, inhibition of L-selectin shedding significantly increased firm adhesion and transmigration by a lymphocyte function–associated antigen (LFA)-1 and
A, Hafezi-Moghadam +4 more
openaire +2 more sources
Frontiers in Medicine, 2020 Selectins [endothelial (E), platelet (P), and leucocytes (L)] are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory.
Hiten D. Mistry +5 more
doaj +1 more source