Results 31 to 40 of about 44,172 (240)

Dysregulation of Biomarkers of Hemostatic Activation and Inflammatory Processes are Associated with Adverse Outcomes in Pulmonary Embolism

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction The pathophysiology of pulmonary embolism (PE) represents complex, multifactorial processes involving blood cells, vascular endothelium, and the activation of inflammatory pathways.
Iman Darwish B.S., Jawed Fareed PhD, Yevgeniy Brailovsky D.O., Debra Hoppensteadt PhD, Brett Slajus M.P.H., Emily Bontekoe B.S., Frank De Stefano B.S., Trent Reed D.O., Amir Darki MSc., M.D.   +8 more
doaj   +1 more source

L-selectin Is Essential for Delivery of Activated CD8+ T Cells to Virus-Infected Organs for Protective Immunity

Cell Reports, 2016
Cytotoxic CD8+ T lymphocytes play a critical role in the host response to infection by viruses. The ability to secrete cytotoxic chemicals and cytokines is considered pivotal for eliminating virus. Of equal importance is how effector CD8+ T cells home to
Rebar N. Mohammed, H. Angharad Watson, Miriam Vigar, Julia Ohme, Amanda Thomson, Ian R. Humphreys, Ann Ager   +6 more
doaj   +1 more source

L-selectin and skin damage in systemic sclerosis.

PLoS ONE, 2012
BackgroundL-selectin ligands are induced on the endothelium of inflammatory sites. L-selectin expression on neutrophils and monocytes may mediate the primary adhesion of these cells at sites of inflammation by mediating the leukocyte-leukocyte ...
James V Dunne, Stephan F van Eeden, Kevin J Keen   +2 more
doaj   +1 more source

Serum E-selectin and endothelial cell-specific Molecule-1 levels among people living with HIV on long term ART in Uganda: a pilot cross-sectional study

AIDS Research and Therapy, 2023
Background Prolonged exposure to HIV and anti-retroviral therapy (ART) has been linked with endothelial cell activation which subsequently predisposes people living with HIV (PLWH) to cardiovascular diseases.
Andrew Weil Semulimi, Charles Batte, Alice Bayiyana, Mariam Nakabuye, John Mukisa, Barbara Castelnuovo, Rosalind Parkes Ratanshi, Bruce J Kirenga, Isaac Ssinabulya   +8 more
doaj   +1 more source

Homing in on L-Selectin [PDF]

The Journal of Immunology, 2006
By 1983, when the article by Gallatin, Weissman, and Butcher ([1][1]) was published in Nature , it was clear that blood-borne lymphocytes migrate selectively (“home”) to secondary lymphoid organs.
openaire   +2 more sources

Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes

eLife, 2016
Myeloid-derived suppressor cells (MDSC) contribute to an immunosuppressive network that drives cancer escape by disabling T cell adaptive immunity. The prevailing view is that MDSC-mediated immunosuppression is restricted to tissues where MDSC co-mingle ...
Amy W Ku, Jason B Muhitch, Colin A Powers, Michael Diehl, Minhyung Kim, Daniel T Fisher, Anand P Sharda, Virginia K Clements, Kieran O'Loughlin, Hans Minderman, Michelle N Messmer, Jing Ma, Joseph J Skitzki, Douglas A Steeber, Bruce Walcheck, Suzanne Ostrand-Rosenberg, Scott I Abrams, Sharon S Evans   +17 more
doaj   +1 more source

Toll-Like Receptor induced CD11b and L-selectin response in patients with coronary artery disease. [PDF]

PLoS ONE, 2013
Toll-Like Receptor (TLR) -2 and -4 expression and TLR-induced cytokine response of inflammatory cells are related to atherogenesis and atherosclerotic plaque progression.
Ellen H A M Elsenberg, Marieke A Hillaert, Hester M den Ruijter, Jan-Willem E M Sels, Vincent P W Scholtes, Hendrik M Nathoe, Johan Kuiper, J Wouter Jukema, Pieter A Doevendans, Gerard Pasterkamp, Imo E Hoefer   +10 more
doaj   +1 more source

Stem Cell Enrichment with Selectin Receptors: Mimicking the pH Environment of Trauma

Sensors, 2013
The isolation of hematopoietic stem and progenitor cells (HSPCs) is critical for transplantation therapy and HSPC research, however current isolation techniques can be prohibitively expensive, time-consuming, and produce variable results. Selectin-coated
Michael R. King, Jane Liesveld, Thong M. Cao, Michael J. Mitchell   +3 more
doaj   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

P-selectin expression tracks cerebral atrophy in Mexican-Americans

Frontiers in Genetics, 2012
Background and Purpose. We hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure (BP) and cerebral atrophy.
Peter eKochunov, David eGlahn, Elliott eHong, Jack L Lancaster, Joanne eCurran, Matthew eJohnson, Anderson eWinkler, Henry eHolcomb, Jack eKent, Braxton eMitchell, Valeria eKochunov, Rene eOlvera, Shelley eCole, Thomas eDyer, Eric eMoses, Harald eGoring, Laura eAlmasy, Ravi eDuggirala, John eBlangero   +18 more
doaj   +1 more source