Aging Alters the Formation and Functionality of Signaling Microdomains Between L-type Calcium Channels and β2-Adrenergic Receptors in Cardiac Pacemaker Cells [PDF]
Frontiers in Physiology, 2022 Heart rate is accelerated to match physiological demands through the action of noradrenaline on the cardiac pacemaker. Noradrenaline is released from sympathetic terminals and activates β1-and β2-adrenergic receptors (ΑRs) located at the plasma membrane ...
Sabrina Choi +3 more
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Potential binding modes of the gut bacterial metabolite, 5-hydroxyindole, to the intestinal L-type calcium channels and its impact on the microbiota in rats [PDF]
Gut Microbes, 2023 Intestinal microbiota and microbiota-derived metabolites play a key role in regulating the host physiology. Recently, we have identified a gut-bacterial metabolite, namely 5-hydroxyindole, as a potent stimulant of intestinal motility via its modulation ...
Barbora Waclawiková +7 more
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Pathophysiology of Cav1.3 L-type calcium channels in the heart [PDF]
Frontiers in Physiology, 2023 Ca2+ plays a crucial role in excitation-contraction coupling in cardiac myocytes. Dysfunctional Ca2+ regulation alters the force of contraction and causes cardiac arrhythmias. Ca2+ entry into cardiomyocytes is mediated mainly through L-type Ca2+ channels,
Sahil Zaveri +10 more
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Natural L-type calcium channels antagonists from Chinese medicine [PDF]
Chinese MedicineL-type calcium channels (LTCCs), the largest subfamily of voltage-gated calcium channels (VGCCs), are the main channels for Ca2+ influx during extracellular excitation.
Fangfang Xu +4 more
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Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine [PDF]
Nature CommunicationsL-type voltage-gated calcium channels are involved in multiple physiological functions. Currently available antagonists do not discriminate between L-type channel isoforms.
Pietro Mesirca +12 more
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The calmodulin-binding, short linear motif, NSCaTE is conserved in L-type channel ancestors of vertebrate Cav1.2 and Cav1.3 channels. [PDF]
PLoS ONE, 2013 NSCaTE is a short linear motif of (xWxxx(I or L)xxxx), composed of residues with a high helix-forming propensity within a mostly disordered N-terminus that is conserved in L-type calcium channels from protostome invertebrates to humans.
Valentina Taiakina +6 more
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Calcium Channels in the Heart: Disease States and Drugs
Cells, 2022 Calcium ions are the major signaling ions in the cells. They regulate muscle contraction, neurotransmitter secretion, cell growth and migration, and the activity of several proteins including enzymes and ion channels and transporters. They participate in
Kajol Shah +4 more
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Denitration of L‐type calcium channel [PDF]
FEBS Letters, 2008 Tyrosine nitration results in altered function of selective proteins, including human smooth muscle L‐type calcium channel, hCav1.2b. We report here that Cav1.2 is also subject to “denitration”. Cell lysates from activated macrophage‐like cell line, RAW264.7 cells, reversed peroxynitrite‐induced nitration of the carboxy terminus of Cav1.2 in a 1D gel ...
Kang, Minho, Akbarali, Hamid I.
openaire +2 more sources
Cells, 2022 Voltage-gated calcium channels (VGCCs) and estrogen receptors are important cellular proteins that have been shown to interact with each other across varied cells and tissues.
Yashashwini Dinesh Subbamanda +1 more
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Forskolin Regulates L-Type Calcium Channel through Interaction between Actinin 4 and β3 Subunit in Osteoblasts. [PDF]
PLoS ONE, 2015 Voltage-dependent L-type calcium channels that permit cellular calcium influx are essential in calcium-mediated modulation of cellular signaling. Although the regulation of voltage-dependent L-type calcium channels is linked to many factors including ...
Xuemei Zhang +6 more
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