Results 101 to 110 of about 13,174,260 (209)

Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum

Memorias do Instituto Oswaldo Cruz, 2004
Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and ...
Izabel Cristina Piloto Ferreira, Maria Valdrinez Campana Lonardoni, Gerzia MC Machado, Leonor L Leon, Lucílio Gobbi Filho, Luís Henrique Bissoli Pinto, Arildo José Braz de Oliveira   +6 more
doaj   +1 more source

Peptides as a Therapeutic Alternative Against Leishmaniasis: A Scoping Review

Chemical Biology &Drug Design, Volume 107, Issue 5, May 2026.
This scoping review of 79 studies identified 231 antimicrobial peptides with anti‐Leishmania activity, including natural‐derived and synthetic peptides (inspired by natural sources or developed through rational design). Most were evaluated in vitro against promastigote and/or amastigote forms, with synthetic peptides showing a more promising effect ...
Maria Eduarda da Veiga Oliveira, Ellen Dyminski Parente Ribeiro, Otávio Henrique Pradi Guenther, Fernanda Tomiotto‐Pellissier   +3 more
wiley   +1 more source

Enlargement of L. amazonensis PVs.

, 2012
(A) Immunostaining of LAMP1 for L. amazonensis PV identification in fixed samples of infected macrophages. Red color represents LAMP1 labeling, blue color represents DAPI stain, and green color represents CFSE staining (upper panel) or immunostaining ...
Renato A. Mortara (110636), Fernando Real (185142)   +1 more
core   +1 more source

Role of Leishmania (Leishmania) amazonensis amastigote glycosphingolipids in macrophage infectivity

Brazilian Journal of Medical and Biological Research, 2007
The role of glycosphingolipids (GSLs) present in amastigote forms of Leishmania (Leishmania) amazonensis during infection of macrophages was analyzed, with particular emphasis on GSLs presenting the terminal Galpß1-3Galpa disaccharide.
A.K. Tanaka, P.A.J. Gorin, H.K. Takahashi, A.H. Straus   +3 more
doaj  

Peptide selection via phage display to inhibit Leishmania-macrophage interactions

Frontiers in Microbiology
IntroductionLeishmaniasis comprises a complex group of diseases caused by protozoan parasites from the Leishmania genus, presenting a significant threat to human health.
Juliane Buzzon Meneghesso Verga, Márcia A. S. Graminha, Marcelo Jacobs-Lorena, Sung-Jae Cha   +3 more
doaj   +1 more source

Hepcidin promotes L. amazonensis growth in macrophages.

, 2014
(A) Effect of iron loading and hepcidin on the intracellular replication of L. amazonensis. BMDM were infected with L. amazonensis axenic amastigotes (L.a). L.a, 1 h infection; Hepcidin+L.a, 4 h of hepcidin treatment followed by 1 h infection; Fe-NTA+L.a,
Norma W. Andrews (39), Danilo C. Miguel (316200), Diane M. Ward (376380), Rym Ben-Othman (140598), Jerry Kaplan (376382), Andrew R. Flannery (516990)   +5 more
core   +1 more source

Antileishmanial activity of lapachol analogues

Memorias do Instituto Oswaldo Cruz, 2004
The antileishmanial activity of lapachol, isolapachol, and dihydrolapachol, along with soluble derivatives (potassium salt) and acetate was obtained. All the compounds were assayed against metacyclic promastigotes of two different species of Leishmania ...
Nadja MF Lima, Clariane S Correia, Leonor L Leon, Gérzia MC Machado, Maria de Fátima Madeira, Antônio Euzébio G Santana, Marília OF Goulart   +6 more
doaj   +1 more source

Leishmania amazonensisdownregulates macrophage iNOS expression via Histone Deacetylase 1 (HDAC1): a novel parasite evasion mechanism

, 2018
The induced expression of nitric oxide synthase (iNOS) controls the intracellular growth of Leishmania in infected macrophages. Histones deacetylases (HDACs) negatively regulate gene expression through the formation of complexes containing transcription ...
Rath, C.T., de Castro Gomes, C.M., Pereira, RMS, Calegari-Silva, T.C., Fasel, N., Pinto, CAS, Vivarini, Á.C., Corbett, CEP, Pacheco, ASS, Dias-Teixeira, K.L., Silva, GBL, Dos Santos, J.V., Saliba, A.M., Lopes, U.G., Teresa C. Calegari‐Silva, Renata de M. S. Pereira, Saliba AM, Amanda S. S. Pacheco, Calegari-Silva TC, Pinto CAS, Gabrielle B. L. Silva, Claudia M. Castro Gomes, Vivarini ÁC, José V. dos Santos, Alessandra M. Saliba, Nicolas Fasel, Gomes, Claudia M. de Castro, de Castro Gomes CM, Karina L. Dias‐Teixeira, Carolina T. Rath, Dias-Teixeira KL, Dos Santos JV, Corbett CEP, Carlos E. P. Corbett, Pacheco ASS, Áislan C. Vivarini, Fasel N, Ulisses G. Lopes, Charlene A. S. Pinto, Pereira RMS, Lopes UG, Rath CT, Silva GBL   +42 more
core   +1 more source

Role of B-1 cells in the infection by Leishmania (L.) amazonensis

, 2016
Parasitos do gênero Leishmania causam um espectro de doenças chamadas de leishmaniose. Para compreender de melhor forma a imunobiologia da Leishmania, o estudo de outras células envolvidas no processo de infecção do parasito se torna importante.
Ferreira, Natália Soares
core   +1 more source

Toll-like receptors 2, 4, and 9 expressions over the entire clinical and immunopathological spectrum of American cutaneous leishmaniasis due to Leishmania(V.) braziliensis and Leishmania (L.) amazonensis.

PLoS ONE, 2018
Leishmania (V.) braziliensis and Leishmania(L.) amazonensis are the most pathogenic agents of American Cutaneous Leishmaniasis in Brazil, causing a wide spectrum of clinical and immunopathological manifestations, including: localized cutaneous ...
Marliane Batista Campos, Luciana Vieira do Rêgo Lima, Luciana Vieira do Rêgo Lima, Ana Carolina Stocco de Lima, Thiago Vasconcelos Dos Santos, Patrícia Karla Santos Ramos, Claudia Maria de Castro Gomes, Fernando Tobias Silveira   +7 more
doaj   +1 more source