Results 91 to 100 of about 13,174,260 (209)

Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action.

PLoS ONE, 2020
Leishmaniasis is a disease impacting public health worldwide due to its high incidence, morbidity and mortality. Available treatments are costly, lengthy and toxic, not to mention the problem of parasite resistance.
Lais S Morais, Renata G Dusi, Daniel P Demarque, Raquel L Silva, Lorena C Albernaz, Sônia N Báo, Christian Merten, Luciana M R Antinarelli, Elaine S Coimbra, Laila S Espindola   +9 more
doaj   +1 more source

Potential vectors of Leishmaniases in the Environmental Protection Area and Tinguá Federal Biological Reserve, Municipality of Nova Iguaçu, Rio de Janeiro, Brazil

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 246-259, June 2026.
This study was to describe the composition of sand fly fauna, detect potential vectors of Leishmania spp. in the Tinguá district, an ATL endemic, Rio de Janeiro, Brazil. Seven species of vectorial importance in the epidemiological cycle of leishmaniasis was observed: Nyssomyia intermedia, Migonemyia migonei, Pintomyia fischeri, Psychodopygus hirsutus ...
Antônio L. F. Santana, Alfredo C. R. Azevedo, Margarete M. S. Afonso, Bruno M. Carvalho, Vanessa R. Vieira, Simone M. Costa, Júlia S. Silva, Thais A. Pereira, Daniela P. Pereira, Maurício L. Vilela   +9 more
wiley   +1 more source

Leishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis

Frontiers in Microbiology, 2018
The present study focused on the activity of the palladacycle complex DPPE 1.1 on Leishmania (Leishmania) amazonensis. Promastigotes of L. (L.) amazonensis were destroyed in vitro by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes
Isabela B. dos Santos, Danielle A. M. da Silva, Fabiana A. C. R. Paz, Daniel M. Garcia, Adriana K. Carmona, Daniela Teixeira, Ieda M. Longo-Maugéri, Simone Katz, Clara L. Barbiéri   +8 more
doaj   +1 more source

Canine Leishmaniasis in Rio de Janeiro, Brazil (2000–2015): Taxonomic Characterisation of Etiological Agents and Geospatial Case Analysis

Zoonoses and Public Health, Volume 73, Issue 4, Page 314-325, June 2026.
ABSTRACT Introduction Canine Leishmaniasis is a vector‐borne zoonotic disease caused by several species of protozoa of the genus Leishmania. In the state of Rio de Janeiro (RJ), Leishmania braziliensis is the most prevalent species causing tegumentary leishmaniasis (TL) and Leishmania infantum is the main causative agent of visceral leishmaniasis (VL).
Luciana de Freitas Campos Miranda, Laryssa Fabiano do Rosário Coelho, Samanta Cristina das Chagas Xavier, Artur Augusto Velho Mendes Junior, Renan Nunes Albuquerque, Aline Fagundes da Silva, Andreza Pain Marcelino, Fernanda Nunes Santos, Sandro Antonio Pereira, Rodrigo Caldas Menezes, Armando de Oliveira Schubach   +10 more
wiley   +1 more source

Papel de PI3K na invasão celular e maturação de fagolisossomos de L. (L.) amazonensis [PDF]

, 2009
Cutaneous leishmaniasis caused by Leishmania (L.) amazonensis is largely distributed throughout the country and can manifest as severe and disseminated lesions in man and other animals.
Guimarães, Renata Junqueira Rezende
core  

Activity of MF against promastigotes of L. amazonensis.

, 2014
MF susceptibility in promastigotes of L. amazonensis mutants and wild-type parasites. EC50 values for MF against M2269 strain, 2506 isolate and MF150.3-1 mutants were determined by MTT as described in Material and Methods.
Silvia R. B. Uliana (240903), Cristiana T. Trinconi (561717), Carlos H. N. Costa (366149), Adriano C. Coelho (133676)   +3 more
core   +1 more source

Structural basis of secreted acid phosphatase polymerization in the Leishmania parasite

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Enzymes that assemble into filaments typically transition between protomeric and polymeric states in response to cellular conditions. In contrast, the secreted acid phosphatase (SAP) of Leishmania, one of the most abundant extracellular glycoproteins produced by the parasite and regarded as a major virulence factor in the neglected tropical ...
Priyanka Bose, Irit Dahan, Alexander Upcher, Ran Zalk, Iris Grossman‐Haham   +4 more
wiley   +1 more source

Therapeutic potential of hesperidin methyl chalcone in the experimental treatment of cutaneous leishmaniasis [PDF]

Acta Amazonica
Drug repositioning seeks to discover new applications for a drug that has already been approved in the market, resulting in faster and lower cost solutions, generally used for diseases that receive little investment, such as cutaneous leishmaniasis.
Anny Maíza Vargas BRASIL, João Roberto de Figueiredo LOPES, Ana Flávia da Silva CHAGAS, Antonia Maria Ramos FRANCO   +3 more
doaj   +1 more source

Nano‐Encapsulated Cinnamomum cassia Essential Oil in Combination With Fluconazole Exhibits Synergistic Activity Against Fluconazole‐Resistant Nakaseomyces glabratus and Pichia kudriavzevii

Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Nano‐encapsulated Cinnamomum cassia essential oil (nano‐CC‐EO) showed in vitro antifungal activity against fluconazole‐resistant Nakaseomyces glabratus and Pichia kudriavzevii clinical isolates. Checkerboard assays revealed synergistic or additive interactions between nano‐CC‐EO and fluconazole in several isolates, without evidence of antagonism. These
Mehrdad Seifi, Mohammad Ali Esfandiary, Negar Hemmati, Javad Malakootikhah, Donya Nikaein, Ali Reza Khosravi   +5 more
wiley   +1 more source

The impaired Th1 immune response of C3HeB/FeJ mice infected with Leishmania amazonensis: lessons learned from immunotherapy and vaccines [PDF]

, 2004
Leishmaniasis is a zoonotic disease caused by intracellular protozoan parasites of the genus Leishmania. Leishmania major and Leishmania amazonensis are both causative agents of cutaneous leishmaniasis in the Old and New World, respectively.
Vanloubbeeck, Yannick
core   +1 more source