Results 71 to 80 of about 6,477 (171)

Antileishmanial compounds from Connarus suberosus: Metabolomics, isolation and mechanism of action.

PLoS ONE, 2020
Leishmaniasis is a disease impacting public health worldwide due to its high incidence, morbidity and mortality. Available treatments are costly, lengthy and toxic, not to mention the problem of parasite resistance.
Lais S Morais, Renata G Dusi, Daniel P Demarque, Raquel L Silva, Lorena C Albernaz, Sônia N Báo, Christian Merten, Luciana M R Antinarelli, Elaine S Coimbra, Laila S Espindola   +9 more
doaj   +1 more source

Exploring the Role of the MAPK Signalling Pathway in Dog Immunity: From Cancer to Parasitic Diseases

Parasite Immunology, Volume 48, Issue 5, May 2026.
ABSTRACT Mitogen‐activated protein kinases (MAPKs) are intracellular signalling proteins that modulate several cellular processes, such as proliferation, cytokine production and survival. Like humans, dogs may exhibit changes in MAPK signalling under pathological conditions.
Francini Neves Ribeiro, Fernanda Nazaré Morgado, Renato Porrozzi   +2 more
wiley   +1 more source

Leishmanicidal and Immunomodulatory Activities of the Palladacycle Complex DPPE 1.1, a Potential Candidate for Treatment of Cutaneous Leishmaniasis

Frontiers in Microbiology, 2018
The present study focused on the activity of the palladacycle complex DPPE 1.1 on Leishmania (Leishmania) amazonensis. Promastigotes of L. (L.) amazonensis were destroyed in vitro by nanomolar concentrations of DPPE 1.1, whereas intracellular amastigotes
Isabela B. dos Santos, Danielle A. M. da Silva, Fabiana A. C. R. Paz, Daniel M. Garcia, Adriana K. Carmona, Daniela Teixeira, Ieda M. Longo-Maugéri, Simone Katz, Clara L. Barbiéri   +8 more
doaj   +1 more source

Metalloids: Semi as Metals yet Full of Antimicrobial Potential

ChemMedChem, Volume 21, Issue 7, 14 April 2026.
Metalloids such as boron (B), silicon (Si), germanium (Ge), arsenic (As), antimony (Sb), and tellurium (Te) bridge metals and non‐metals, displaying unique chemical versatility. Recent research highlights their diverse antimicrobial and therapeutic potentials, from natural products to synthetic organic and organometallic molcules, underscoring renewed ...
Kevin Böhm, Muhammad Jawad Nasim, Claus Jacob   +2 more
wiley   +1 more source

Brain Involvement in Leishmaniasis

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT Leishmaniasis is a neglected tropical disease caused by infection with the protozoan parasite Leishmania and it is a significant global health problem. The disease has a wide clinical spectrum, from tegumentary leishmaniasis (TL) that encompasses cutaneous (CL), mucosal (ML) and cutaneous‐diffuse (CDL) forms, to the potentially fatal systemic ...
Camila S. Freitas, Eduardo A. F. Coelho, Myron Christodoulides   +2 more
wiley   +1 more source

Therapeutic potential of hesperidin methyl chalcone in the experimental treatment of cutaneous leishmaniasis [PDF]

Acta Amazonica
Drug repositioning seeks to discover new applications for a drug that has already been approved in the market, resulting in faster and lower cost solutions, generally used for diseases that receive little investment, such as cutaneous leishmaniasis.
Anny Maíza Vargas BRASIL, João Roberto de Figueiredo LOPES, Ana Flávia da Silva CHAGAS, Antonia Maria Ramos FRANCO   +3 more
doaj   +1 more source

Leishmania Extracellular Vesicles as a Preventive Vaccine Platform Against Leishmaniasis

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
The potential of Leishmania‐derived extracellular vesicles (EVs) as a vaccine platform was investigated, emphasizing an affordable, GMP‐compliant production and purification method. Immunization with EV vaccines, either unadjuvanted or combined with α‐galactosylceramide (αGC), induced robust humoral and cellular immune responses, conferring protection ...
Ismail Cem Yilmaz, Ibrahim Tokmak, Muzaffer Yildirim, Tugce Canavar Yildirim, Elif Sena Ozkoc, Irem Evcili, Emre Mert Ipekoglu, İhsan Cihan Ayanoglu, Emre Dunuroglu, Dicle Caliskan, Harun Onler, Zeynep Arzum, Ceren Ulker, Olcay Mert, Ridvan Orkut, Ibrahim Oguzhan Tarman, Ulku Guler, Bekir Salih, Volkan Yazar, Gokcen Ozgun, Serap Birincioglu, Ahmet Ozbilgin, Bilgi Gungor, Ihsan Gursel, Mayda Gursel   +24 more
wiley   +1 more source

Anti-leishmanial activity of alkaloidal extract from Aspidosperma ramiflorum

Memorias do Instituto Oswaldo Cruz, 2004
Infections due to protozoa of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials (SbV), which present renal and ...
Izabel Cristina Piloto Ferreira, Maria Valdrinez Campana Lonardoni, Gerzia MC Machado, Leonor L Leon, Lucílio Gobbi Filho, Luís Henrique Bissoli Pinto, Arildo José Braz de Oliveira   +6 more
doaj   +1 more source

Comprehensive Analysis of Structure Activity Relationships in Quinoxaline Derivatives Covering Antimicrobial Applications

ChemistrySelect, Volume 11, Issue 14, 13 April 2026.
ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma, Fernando Rogério Pavan, Cesar Augusto Roque‐Borda   +2 more
wiley   +1 more source

Role of Leishmania (Leishmania) amazonensis amastigote glycosphingolipids in macrophage infectivity

Brazilian Journal of Medical and Biological Research, 2007
The role of glycosphingolipids (GSLs) present in amastigote forms of Leishmania (Leishmania) amazonensis during infection of macrophages was analyzed, with particular emphasis on GSLs presenting the terminal Galpß1-3Galpa disaccharide.
A.K. Tanaka, P.A.J. Gorin, H.K. Takahashi, A.H. Straus   +3 more
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