Results 71 to 80 of about 13,174,260 (209)

Desenvolvimento de um teste colorimétrico para triagem da atividade leishmanicida de compostos utilizando Leishmania amazonensis expressando a enzima beta-galactosidase [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Programa de Pós-graduação em Biotecnologia e Biociências, Florianópolis, 2013No presente trabalho transfectamos uma cepa de Leishmania amazonensis com um plasmídeo contendo o gene da ...
Tonini, Maiko Luis
core  

Transcriptional signatures accounting for fatty acid metabolism in dendritic leucocytes hosting live L. amazonensis amastigotes.

, 2013
Transcriptional signatures accounting for fatty acid metabolism in dendritic leucocytes hosting live L. amazonensis amastigotes.
Marie-Christine Prévost (2280838), Hervé Lecoeur (82568), Emilie Giraud (111677), Geneviève Milon (57041), Thierry Lang (82572)   +4 more
core   +1 more source

Effect of fungal extracts on L. amazonensis-infected BMDMs.

, 2018
BMDMs were infected with L. amazonensis and treated with fungal extracts (5mg.mL-1) or vehicle for 24h at 37ºC and 5%CO2. (A) Percentage of infected macrophages; (B) a mean number of amastigotes per macrophage.
Daniela Ribeiro Alves (5410343), Fábio Roger Vasconcelos (5410337), Arlindo de Alencar Araripe Noronha (5410346), Francisco das Chagas Oliveira Freire (5410352), Wander Rogério Pavanelli (739263), Selene Maia de Morais (5410355), Alan Henrique Depieri Cataneo (5410361), Isaac Neto Goes da Silva (5410358), Milena Menegazzo Miranda-Sapla (5410334), Ivete Conchon-Costa (739262), Gustavo Adolfo Saavedra Pinto (5410349), Fernanda Tomiotto-Pellissier (5410340)   +11 more
core   +1 more source

VAPA mediates lipid exchange between Leishmania amazonensis and host macrophages.

PLoS Pathogens
Leishmania is a vacuolar pathogen that replicates within parasitophorous vacuoles inside host phagocytes. To promote its replication, Leishmania relies on a panoply of strategies to acquire macromolecules such as lipids from host macrophages.
Ilona Gdovinova, Albert Descoteaux
doaj   +1 more source

Evaluation of Uliginosin B as a Modulator of the Ras Pathway: In Vivo Evidence From Caenorhabditis elegans and In Silico Insights

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
This study performs in vivo and in silico assays with uliginosin B, targeting its activity in the Ras signaling pathway, demonstrating a possible allosteric interaction with the HRAS (human) and LET‐60 (nematode) proteins, and a decrease in the overexpression of the let‐60 gene in the nematode C. elegans.
Maria Eduarda O. De Souza, Flávia Suelen De O. Pereira, Daniela Teixeira Rodrigues, Helder Dias Costa, Tarsila Dantas Da Rosa, Camila Machado Pires da Silva, Gilsane von Poser, Stela M. K. Rates, Favero R. Paula, Daiana Silva Ávila   +9 more
wiley   +1 more source

Biological activities of 1,4-naphthoquinones derivatives against T. cruzi and L. amazonensis

Revista Colombiana de Ciencias Químico-Farmacéuticas, 2022
Introduction: Chagas disease and Leishmaniasis are neglected diseases caused bythe Trypanosoma cruzi and kentoplastid parasites Leishmania spp. Parasitic diseasescause great impact on social and economic, affecting millions of people in the worldand represent a major global health problem.
Adriano Olímpio da Silva, Rosangela Da Silva Lopes, Aline Alves dos Santos Naujorks, Celso Vataru Nakamura, Dênis Pires de Lima   +4 more
openaire   +1 more source

L. amazonensis infection causes iron accumulation and ferritin upregulation in macrophages.

, 2014
(A) Effect of L. amazonensis infection on H-ferritin (FTH1) transcript levels. BMDM were infected or not with axenic L. amazonensis amastigotes (L.a) for 1 h, washed and cultured at 34°C for another 24 or 48 h, followed by quantification of FTH1 and ...
Norma W. Andrews (39), Danilo C. Miguel (316200), Diane M. Ward (376380), Rym Ben-Othman (140598), Jerry Kaplan (376382), Andrew R. Flannery (516990)   +5 more
core   +1 more source

Functional analysis of the LRR17 protein, rich in leucine repeats and secreted by Leishmania (Viannia) braziliensis and L. (Leishmania) amazonensis.

, 2011
As repetições ricas em leucina (LRR) são domínios presentes em diversas famílias de proteínas com diferentes funções, sendo responsáveis pela formação de uma estrutura capaz de estabelecer interações protéicas. Em decorrência do projeto de caracterização
Alessandro Aparecido Rodrigues da Silva, Silva, Alessandro Aparecido Rodrigues da   +1 more
core   +1 more source

In vitro evaluation of the anti-leishmanial activity and toxicity of PK11195

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Leishmaniasis, one of the most neglected diseases, is a serious public health problem in many countries, including Brazil. Currently available treatments require long-term use and have serious side effects, necessitating the development of new
Carlos Eduardo Sampaio Guedes, Beatriz Rocha Simões Dias, Antonio Luis de Oliveira Almeida Petersen, Kercia Pinheiro Cruz, Niara de Jesus Almeida, Daniela Rodrigues Andrade, Juliana Perrone Bezerra de Menezes, Valéria de Matos Borges, Patricia Sampaio Tavares Veras   +8 more
doaj   +1 more source

Exploring Biological Properties of Manganese(II)‐Phenanthroline‐Based Complexes: In Vitro Insights

ChemistrySelect, Volume 11, Issue 29, 3 August 2026.
Four Mn(II) complexes with phenanthroline derivatives were studied. These compounds were tested against several parasites and different human cancer cells. Despite its cytotoxicity on breast cancer, DNA seems not to be the main biological target. These complexes can drive the design and development of new metal‐based agents with improved biological ...
Roberto S. Silva, Marcos V. Palmeira‐Mello, Mikaelly P. Caet, Celisnolia M. Leite, Arieli B. Portugal, Pedro H. Machado, Alexandre B. Carvalho, Isabel Correia, Leonardo M. Moreira, Thatiana L. B. V. Simão, Elena Lasunskaia, Michelle F. Muzitano, José L. Nepomuceno‐Silva, João L. M. Wanderley, Javier Ellena, Alzir A. Batista, Mario S. Schultz   +16 more
wiley   +1 more source