Results 61 to 70 of about 1,561,247 (279)

Between Condemnation and Restoration. The Idea and Practices of Restorative Justice in the Context of the Rehabilitation of Offenders

Journal of Modern Science, 2022
Objectives The aim of this paper is to outline the specifics and meaning of the idea of restorative justice in the context of dealing with offenders, as well as the approach to crime, including its genesis, forms, and methods. Another important aspect is
Dawid Kamil Wieczorek
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

1-Relaxed Edge-Sum Labeling Game [PDF]

, 2015
We introduce a new graph labeling and derive a game on graphs called the 1-relaxed modular edge-sum labeling game. Given a graph G and a natural number n, we define a labeling by assigning to each edge a number from {1,..., n} and assign a corresponding ...
Do, Hang, Moran, Brent, Singer, Timothy
core   +1 more source

Magnetoencephalography Atlas Viewer for Dipole Localization and Viewing

Journal of Imaging
Magnetoencephalography (MEG) is a noninvasive neuroimaging technique widely recognized for epilepsy and tumor mapping. MEG clinical reporting requires a multidisciplinary team, including expert input regarding each dipole’s anatomic localization.
N.C.d. Fonseca, Jason Bowerman, Pegah Askari, Amy L. Proskovec, Fabricio Stewan Feltrin, Daniel Veltkamp, Heather Early, Ben C. Wagner, Elizabeth M. Davenport, Joseph A. Maldjian   +9 more
doaj   +1 more source

Visual Active Learning for Labeling: A Case for Soundscape Ecology Data

Information, 2021
Labeling of samples is a recurrent and time-consuming task in data analysis and machine learning and yet generally overlooked in terms of visual analytics approaches to improve the process.
Liz Huancapaza Hilasaca, Milton Cezar Ribeiro, Rosane Minghim   +2 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Fluorescent labeling of plasmid DNA and mRNA : gains and losses of current labeling strategies [PDF]

, 2016
Live-cell imaging has provided the life sciences with insights into the cell biology and dynamics. Fluorescent labeling of target molecules proves to be indispensable in this regard. In this Review, we focus on the current fluorescent labeling strategies
Rombouts, Koen, Braeckmans, Kevin, Remaut, Katrien   +2 more
core   +1 more source

Scavenger receptor BI facilitates hepatic very low density lipoprotein production in mice

Journal of Lipid Research, 2010
Scavenger receptor BI (SR-BI) is a selective uptake receptor for HDL cholesterol but is also involved in the catabolism of apolipoprotein (apo)B-containing lipoproteins. However, plasma levels of apoB-containing lipoproteins increase following hepatic SR-
Harmen Wiersma, Niels Nijstad, Thomas Gautier, Jahangir Iqbal, Folkert Kuipers, M. Mahmood Hussain, Uwe J.F. Tietge   +6 more
doaj   +1 more source