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Tegoprazan-Based Triple Therapy for Helicobacter pylori Eradication: A Phase III Multicenter Randomized Clinical Trial. [PDF]
Park JY +19 more
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LAC-TME classifier: machine learning-driven model predicts survival and prioritizes targeted therapy in clear cell renal cell carcinoma. [PDF]
He J, Qi L, Cai Y, Chen M, Wang Y.
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A Metabolites' Interplay Can Modulate DNA Repair by Homologous Recombination. [PDF]
Rossi V +7 more
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How Lac repressor finds lac operator in vitro
Journal of Molecular Biology, 1992Filter-binding and gel mobility shift assays were used to analyse the kinetics of the interaction of Lac repressor with lac operator. A comparison of the two techniques reveals that filter-binding assays with tetrameric Lac repressor have often been misinterpreted.
R, Fickert, B, Müller-Hill
exaly +3 more sources
Angewandte Chemie International Edition in English, 1971
AbstractRepressors are proteins that interact with inducers and operators to regulate the synthesis of enzymes in the cell. Lac repressor ensures that sufficient β‐galactosidase is available to the bacterium Escherichia coli, depending upon the amount of lactose present in the culture medium. It has proved possible to isolate lac repressor from E.coli.
exaly +3 more sources
AbstractRepressors are proteins that interact with inducers and operators to regulate the synthesis of enzymes in the cell. Lac repressor ensures that sufficient β‐galactosidase is available to the bacterium Escherichia coli, depending upon the amount of lactose present in the culture medium. It has proved possible to isolate lac repressor from E.coli.
exaly +3 more sources
A model for the binding of lac repressor to the lac operator
Molecular Biology Reports, 1976A model is suggested for the lac repressor binding to the lac operator in which the repressor polypeptide chain sequences from Gly 14 to Ala 32 and from Ala 53 to Leu 71 are involved in specific interaction with operator DNA. A correspondence between the protein and DNA sequences is found which explains specificity of the repressor binding to the lac ...
G V, Gursky +5 more
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NMR Studies of lac Operator and lac Repressor
2003For many years, and even now, the lac operon of Escherichia coli has been a model for gene regulation. The lac repressor is a tetrameric protein that binds strongly the lac operator and the affinity of which is modulated by an inducer molecule. The lac repressor–lac operator complex was the first nucleic acid–protein complex studied with success by NMR.
Lancelot, Gérard, Paquet, Françoise
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Binding of lac repressor to the secondary lac operator in Escherichia coli
Molecular and General Genetics MGG, 1978In the lac operon, the existence of a secondary repressor binding site, inside Z gene, had been inferred from in vitro binding studies (Reznikoff et al., 1974; Gilbert et al., 1975). A series of deletions have been constructed from a lac transducing lambda bacteriophage.
A, Rambach, M, Lebastard
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