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Allostery and the lac Operon

Journal of Molecular Biology, 2013
The ability to regulate gene expression is essential for controlling metabolic events in a cell. Proteins that function like molecular switches respond to fluctuations in the environment to maintain homeostasis. The operon model, proposed by Jacob and Monod, provides a cogent depiction for how gene expression is regulated. A molecular mechanism for the
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Lac repressor — Lac operator complexes

European Biophysics Journal, 1987
Complexes between the Lac repressor and a small DNA operator fragment (29 base pairs) were investigated using polyacrylamide gel electrophoresis and solution X-ray scattering. Titration of the DNA fragment with the repressor, followed by gel electrophoresis showed that only two types of complexes are formed with repressor/operator ratios of 0.5 and 2 ...
F, Culard   +3 more
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The lac operator nucleosomes. 2. lac Nucleosomes can change conformation to strengthen binding by lac repressor

Biochemistry, 1980
We have shown previously that lac repressor binds specifically and quantitatively to lac operator restriction fragments which have been complexed with histones to form artificial nucleosomes (203 base pair restriction fragment) or core particles (144 base pair restriction fragment.
M V, Chao, H G, Martinson, J D, Gralla
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Lac

World Literature Today, 1990
Emile J. Talbot, Jean Echenoz
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Lac-time?*

Critical Care Medicine, 2004
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Lac and the Lac Insect

Scientific American, 1878
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Lac

1902
B. Fischer, C. Hartwich
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Lac

1910
B. Fischer, C. Hartwich
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