Origin of bistability in the lac Operon. [PDF]
Biophys J, 2007 Multistability is an emergent dynamic property that has been invoked to explain multiple coexisting biological states. In this work, we investigate the origin of bistability in the lac operon. To do this, we develop a mathematical model for the regulatory pathway in this system and compare the model predictions with other experimental results in which ...
Santillán M, Mackey MC, Zeron ES.
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Dynamic model of gene regulation for the lac operon [PDF]
Journal of Physics: Conference Series, 2011 Gene regulatory network is a collection of DNA which interact with each other and with other matter in the cell. The lac operon is an example of a relatively simple genetic network and is one of the best-studied structures in the Escherichia coli ...
Asma Ben-Halim +7 more
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The Selective Advantage of the lac Operon for Escherichia coli Is Conditional on Diet and Microbiota Composition [PDF]
Frontiers in Microbiology, 2021 The lac operon is one of the best known gene regulatory circuits and constitutes a landmark example of how bacteria tune their metabolism to nutritional conditions.
Catarina Pinto +3 more
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Diversity in
mBio, 2019 Transcription of bacterial genes is controlled by the coordinated action of cis- and trans-acting regulators. The activity and mode of action of these regulators can reflect different requirements for gene products in different environments.
Kelly N. Phillips +6 more
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Direct measurements of IPTG enable analysis of the induction behavior of
Microbial Cell Factories, 2012 Background The E. coli lac operon and its components have been studied for decades, and lac-derived systems are widely used for recombinant protein production.
Fernández-Castané Alfred +2 more
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Building the lac Operon: A Guided-Inquiry Activity Using 3D-Printed Models [PDF]
Journal of Microbiology & Biology Education, 2020 Undergraduate biology courses rely heavily on visual representation of information. Students view images of plants, animals, and microbes, interpret data presented in graphs, and use drawings to understand how cells and molecules interact in three ...
Claire L. Gordy +4 more
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DNA supercoiling, a critical signal regulating the basal expression of the lac operon in Escherichia coli. [PDF]
Sci Rep, 2016 Escherichia coli lac repressor (LacI) is a paradigmatic transcriptional factor that controls the expression of lacZYA in the lac operon. This tetrameric protein specifically binds to the O1, O2 and O3 operators of the lac operon and forms a DNA loop to ...
Fulcrand G +6 more
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Hybrid de novo Genome Assembly of Erwinia sp. E602 and Bioinformatic Analysis Characterized a New Plasmid-Borne lac Operon Under Positive Selection [PDF]
Frontiers in Microbiology, 2021 Our previous study identified a new β-galactosidase in Erwinia sp. E602. To further understand the lactose metabolism in this strain, de novo genome assembly was conducted by using a strategy combining Illumina and PacBio sequencing technology. The whole
Yu Xia +10 more
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Acquisition of the lac operon by Salmonella enterica. [PDF]
BMC Microbiol, 2015 Classical bacteriological characteristics of Salmonella enterica indicate that the members of this species are unable to utilize lactose as a carbon source. However, lactose-fermenting (Lac+) strains of several Salmonella serovars have been isolated from different foodborne outbreaks as well as different geographical regions worldwide.
Leonard SR, Lacher DW, Lampel KA.
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Historical Contingency Causes Divergence in Adaptive Expression of the lac Operon. [PDF]
Mol Biol Evol, 2021 Karkare K +3 more
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