Results 11 to 20 of about 37,884 (225)
What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems [PDF]
Nucl. Acids Res. (13 October 2014) 42 (18): 11321-11328, 2013 Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate selection in viral infection, cell cycle control, and development.
Berg, Johannes +3 more
arxiv +5 more sources
Acquisition of the lac operon by Salmonella enterica. [PDF]
BMC Microbiol, 2015 Classical bacteriological characteristics of Salmonella enterica indicate that the members of this species are unable to utilize lactose as a carbon source. However, lactose-fermenting (Lac+) strains of several Salmonella serovars have been isolated from different foodborne outbreaks as well as different geographical regions worldwide.
Leonard SR, Lacher DW, Lampel KA.
europepmc +5 more sources
Building the lac Operon: A Guided-Inquiry Activity Using 3D-Printed Models [PDF]
Journal of Microbiology & Biology Education, 2020 Undergraduate biology courses rely heavily on visual representation of information. Students view images of plants, animals, and microbes, interpret data presented in graphs, and use drawings to understand how cells and molecules interact in three ...
Claire L. Gordy +4 more
doaj +2 more sources
Transient Repression of the lac Operon [PDF]
Journal of Bacteriology, 1967 Severe transient repression of constitutive or induced β-galactosidase synthesis occurs upon the addition of glucose to cells of Escherichia coli growing on glycerol, succinic acid, or lactic acid. Only mutants particularily well adapted to growth on glucose exhibit this phenomenon when transferred to a glucose ...
B Tyler +2 more
openalex +4 more sources
, 2017 The lac operon is a classic model system for bacterial gene regulation, and has been studied extensively in E. coli, a classic model organism. However, not much is known about E.
Jesse, Fabienne
core +4 more sources
Modeling network dynamics: the lac operon, a case study [PDF]
J. Cell Biol. 161, 471-476 (2003), 2004 We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description -molecular, cellular, and that of cell population- into a single model, which seems to capture many experimental aspects of the ...
José M. G. Vilar +2 more
arxiv +3 more sources
Kinetic approaches to lactose operon induction and bimodality [PDF]
Journal of Theoretical Biology 2013;325:62-75, 2013 The quasi-equilibrium approximation is acceptable when molecular interactions are fast enough compared to circuit dynamics, but is no longer allowed when cellular activities are governed by rare events. A typical example is the lactose operon (lac), one of the most famous paradigms of transcription regulation, for which several theories still coexist ...
Michel, Denis
arxiv +5 more sources
Hybrid de novo Genome Assembly of Erwinia sp. E602 and Bioinformatic Analysis Characterized a New Plasmid-Borne lac Operon Under Positive Selection [PDF]
Frontiers in Microbiology, 2021 Our previous study identified a new β-galactosidase in Erwinia sp. E602. To further understand the lactose metabolism in this strain, de novo genome assembly was conducted by using a strategy combining Illumina and PacBio sequencing technology. The whole
Yu Xia +10 more
doaj +2 more sources
Dynamic model of gene regulation for the lac operon [PDF]
Journal of Physics: Conference Series, 2011 Gene regulatory network is a collection of DNA which interact with each other and with other matter in the cell. The lac operon is an example of a relatively simple genetic network and is one of the best-studied structures in the Escherichia coli ...
Asma Ben-Halim +7 more
core +3 more sources
Direct measurements of IPTG enable analysis of the induction behavior of
Microbial Cell Factories, 2012 Background The E. coli lac operon and its components have been studied for decades, and lac-derived systems are widely used for recombinant protein production.
Fernández-Castané Alfred +2 more
doaj +8 more sources