Results 11 to 20 of about 37,366 (242)
Development of a Lac Operon Concept Inventory (LOCI). [PDF]
CBE Life Sci Educ, 2016 Concept inventories (CIs) are valuable tools for educators that assess student achievement and identify misconceptions held by students. Results of student responses can be used to adjust or develop new instructional methods for a given topic. The regulation of gene expression in both prokaryotes and eukaryotes is an important concept in genetics and ...
Stefanski KM +2 more
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Structure of the lac Operon Galactoside Acetyltransferase [PDF]
Structure, 2002 The galactoside acetyltransferase (thiogalactoside transacetylase) of Escherichia coli (GAT, LacA, EC 2.3.1.18) is a gene product of the classical lac operon. GAT may assist cellular detoxification by acetylating nonmetabolizable pyranosides, thereby preventing their reentry into the cell.
Xingguo Wang +2 more
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From Binary to Multivalued to Continuous Models: The lac Operon as a Case Study [PDF]
Journal of Integrative Bioinformatics, 2010 Using the lac operon as a paradigmatic example for a gene regulatory system in prokaryotes, we demonstrate how qualitative knowledge can be initially captured using simple discrete (Boolean) models and then stepwise refined to multivalued logical models ...
Franke Raimo +2 more
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Physiological regulation of a decontrolled lac operon [PDF]
Journal of Bacteriology, 1977 The expression of the lac operon was studied under a variety of growth conditions in induced and in constitutive cells of Escherichia coli that carried different catabolite-insensitive lac promoters. Use of such "decontrolled" lac operons permitted a study of the expression of an operon that was presumably subject only to passive control. Since the use
Barry L. Wanner +2 more
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Wrapped-around models for the lac operon complex. [PDF]
Biophys J, 2010 The protein-DNA complex, involved in the lac operon of enteric bacteria, is paradigmatic in understanding the extent of DNA bending and plasticity due to interactions with protein assemblies acting as DNA regulators. For the lac operon, two classes of structures have been proposed: 1), with the protein tetramer lying away from the DNA loop (wrapped ...
La Penna G, Perico A.
europepmc +6 more sources
Deterministic and stochastic population-level simulations of an artificial
BMC Bioinformatics, 2011 Background The lac operon genetic switch is considered as a paradigm of genetic regulation. This system has a positive feedback loop due to the LacY permease boosting its own production by the facilitated transport of inducer into the cell and the ...
Zygourakis Kyriacos, Stamatakis Michail
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RNA polymerase supply and flux through the lac operon in Escherichia coli. [PDF]
Philos Trans R Soc Lond B Biol Sci, 2016 Sendy B, Lee DJ, Busby SJ, Bryant JA.
europepmc +3 more sources
The effect of stochasticity on the lac operon: an evolutionary perspective. [PDF]
PLoS Computational Biology, 2007 The role of stochasticity on gene expression is widely discussed. Both potential advantages and disadvantages have been revealed. In some systems, noise in gene expression has been quantified, in among others the lac operon of Escherichia coli.
Milan van Hoek, Paulien Hogeweg
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Bistable behavior of the lac operon in E. coli when induced with a mixture of lactose and TMG [PDF]
Frontiers in Physiology, 2010 In this work we investigate multistability in the lac operon of Escherichia coli when it is induced by a mixture of lactose and the non-metabolizable thiomethyl galactoside (TMG).
Orlando Díaz-Hernández +3 more
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Interplay of protein and DNA structure revealed in simulations of the lac operon. [PDF]
PLoS ONE, 2013 The E. coli Lac repressor is the classic textbook example of a protein that attaches to widely spaced sites along a genome and forces the intervening DNA into a loop.
Luke Czapla +3 more
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