Regulatory region of the divergent Klebsiella pneumoniae lac operon [PDF]
The chromosomal DNA that lies between the lacI and lacZ genes of Klebsiella pneumoniae constitutes a 196-base pair intercistronic region that contains regulatory sequences for both genes. The probable locations of specific regulatory elements for both lacI and lacZ genes were determined by analogy with the corresponding Escherichia coli sequences.
W E Buvinger, Margaret A. Riley
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The lac operon is a classic model system for bacterial gene regulation, and has been studied extensively in E. coli, a classic model organism. However, not much is known about E. coli’s ecology and life outside the laboratory, in particular in soil and water environments.
Fabienne Jesse
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Genomic characterization of Klebsiella spp. from bovine mastitis: dissemination of a conserved, highly transmissible lacacq+ fec+ plasmid drives burden of disease [PDF]
Bovine mastitis poses a significant health concern for dairy cattle and a major economic burden on the dairy industry. Klebsiella spp. are important mastitis pathogens, with previous studies identifying lactose-utilization (lacacq) and iron-acquisition ...
Michael Biggel +5 more
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Modeling network dynamics: the lac operon, a case study [PDF]
We use the lac operon in Escherichia coli as a prototype system to illustrate the current state, applicability, and limitations of modeling the dynamics of cellular networks. We integrate three different levels of description -molecular, cellular, and that of cell population- into a single model, which seems to capture many experimental aspects of the ...
José M. G. Vilar +2 more
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Protein distributions from a stochastic model of the lac operon of E. coli with DNA looping: analytical solution and comparison with experiments. [PDF]
Choudhary K, Oehler S, Narang A.
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Identification of an intestine-specific promoter and inducible expression of bacterial α-galactosidase in mammalian cells by a
Background α-galactosidase has been widely used in animal husbandry to reduce anti-nutritional factors (such as α-galactoside) in feed. Intestine-specific and substrate inducible expression of α-galactosidase would be highly beneficial for transgenic ...
Ya-Feng Zhai +8 more
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Divergent Evolution and Local Establishment of Multidrug-Resistant <i>Shigella sonnei</i> in China. [PDF]
• Evolutionary history and local establishment of Chinese Shigella sonnei are unclear. • Chinese S. sonnei developed into four clades and ONPG‐negative variants. • The antimicrobial resistance phenotype of Clade I was due to an IncB/O/K/Z plasmid. • Antimicrobial resistance of Clade II was due to IncFII and IncB/O/K/Z plasmids.
Liu K +26 more
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The cAMP-CRP regulon coordinates transcription regulation of several energy-related genes, the lac operon among them. Lactose, or IPTG, induces the lac operon expression by binding to the LacI repressor, and releasing it from the promoter sequence.
Chunghwan Ro +2 more
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Lacticaseibacillus casei is used extensively in the fermented milk-beverage industry as a starter culture. Acid production capacity during fermentation is the main criterion for evaluating starters although it is strain-dependent. In this study, the acid
Xiaoxia Li +11 more
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Finite state machine and Markovian equivalents of the lac Operon in E. coli bacterium
The lac operon in E. coli has been extensively studied by computational biologists. The bacterium uses it to survive in the absence of glucose, utilizing lactose for growth.
Urooj Ainuddin, Maria Waqas
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