Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli. [PDF]
PLoS Genetics, 2012 Adaptation to novel environments is often associated with changes in gene regulation. Nevertheless, few studies have been able both to identify the genetic basis of changes in regulation and to demonstrate why these changes are beneficial.
Selwyn Quan +6 more
doaj +1 more source
Delineating the Role of the msaABCR Operon in Staphylococcal Overflow Metabolism
Frontiers in Microbiology, 2022 Staphylococcus aureus is an important human pathogen that can infect almost every organ system, resulting in a high incidence of morbidity and mortality. The msaABCR operon is an important regulator of several staphylococcal phenotypes, including biofilm
Bibek G C +2 more
doaj +1 more source
Nonlinear fitness landscape of a molecular pathway. [PDF]
PLoS Genetics, 2011 Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity of the proteins produced can also reduce fitness ...
Lilia Perfeito +4 more
doaj +1 more source
Comparison of deterministic and stochastic models of the lac operon genetic network. [PDF]
Biophys J, 2009 Stamatakis M, Mantzaris NV.
europepmc +3 more sources
Lac Operon Boolean Models: Dynamical Robustness and Alternative Improvements
Mathematics, 2021 In Veliz-Cuba and Stigler 2011, Boolean models were proposed for the lac operon in Escherichia coli capable of reproducing the operon being OFF, ON and bistable for three (low, medium and high) and two (low and high) parameters, representing the ...
Marco Montalva-Medel +3 more
doaj +1 more source
The Inducible lac Operator-Repressor System Is Functional in Zebrafish Cells
Frontiers in Genetics, 2021 BackgroundZebrafish are a foundational model organism for studying the spatio-temporal activity of genes and their regulatory sequences. A variety of approaches are currently available for editing genes and modifying gene expression in zebrafish ...
Sierra S. Nishizaki +8 more
doaj +1 more source
What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems [PDF]
, 2014 Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate ...
Berg, Johannes +3 more
core +2 more sources
BMC Microbiology, 2020 Background The msaABCR operon regulates several staphylococcal phenotypes such as biofilm formation, capsule production, protease production, pigmentation, antibiotic resistance, and persister cells formation.
Gyan S. Sahukhal +4 more
doaj +1 more source
Supercoiling Effects on Short-Range DNA Looping in E. coli. [PDF]
PLoS ONE, 2016 DNA-protein loops can be essential for gene regulation. The Escherichia coli lactose (lac) operon is controlled by DNA-protein loops that have been studied for decades.
Lauren S Mogil +2 more
doaj +1 more source
Regulation of bistability in the std fimbrial operon of Salmonella enterica by DNA adenine methylation and transcription factors HdfR, StdE and StdF [PDF]
, 2019 Bistable expression of the Salmonella enterica std operon is controlled by an AND logic gate involving three transcriptional activators: the LysR-type factor HdfR and the StdE and StdF regulators encoded by the std operon itself.
Casadesús Pursals, Josep +4 more
core +1 more source