Results 41 to 50 of about 37,884 (225)

The secondary messenger ppGpp interferes with cAMP-CRP regulon by promoting CRP acetylation in Escherichia coli.

open access: yesPLoS ONE, 2021
The cAMP-CRP regulon coordinates transcription regulation of several energy-related genes, the lac operon among them. Lactose, or IPTG, induces the lac operon expression by binding to the LacI repressor, and releasing it from the promoter sequence.
Chunghwan Ro   +2 more
doaj   +2 more sources

The plasmid-encoded lactose operon plays a vital role in the acid production rate of Lacticaseibacillus casei during milk beverage fermentation

open access: yesFrontiers in Microbiology, 2022
Lacticaseibacillus casei is used extensively in the fermented milk-beverage industry as a starter culture. Acid production capacity during fermentation is the main criterion for evaluating starters although it is strain-dependent. In this study, the acid
Xiaoxia Li   +11 more
doaj   +1 more source

Finite state machine and Markovian equivalents of the lac Operon in E. coli bacterium

open access: yesAIMS Bioengineering, 2022
The lac operon in E. coli has been extensively studied by computational biologists. The bacterium uses it to survive in the absence of glucose, utilizing lactose for growth.
Urooj Ainuddin, Maria Waqas
doaj   +1 more source

The endogenous Coxiella burnetii plasmid encodes a functional toxin–antitoxin system

open access: yesMolecular Microbiology, Volume 118, Issue 6, Page 744-764, December 2022., 2022
Coxiella burnetii is an obligate intracellular bacterium and causative agent of Q fever. Here we report that the C. burnetii genome encodes 11 toxin–antitoxin systems, which is highly unusual for intracellular bacteria, and that one TA system is encoded on the large endogenous plasmid found in almost all C. burnetii isolates.
Shaun Wachter   +7 more
wiley   +1 more source

Delineating the Role of the msaABCR Operon in Staphylococcal Overflow Metabolism

open access: yesFrontiers in Microbiology, 2022
Staphylococcus aureus is an important human pathogen that can infect almost every organ system, resulting in a high incidence of morbidity and mortality. The msaABCR operon is an important regulator of several staphylococcal phenotypes, including biofilm
Bibek G C   +2 more
doaj   +1 more source

Nonlinear fitness landscape of a molecular pathway. [PDF]

open access: yesPLoS Genetics, 2011
Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity of the proteins produced can also reduce fitness ...
Lilia Perfeito   +4 more
doaj   +1 more source

Lac Operon Boolean Models: Dynamical Robustness and Alternative Improvements

open access: yesMathematics, 2021
In Veliz-Cuba and Stigler 2011, Boolean models were proposed for the lac operon in Escherichia coli capable of reproducing the operon being OFF, ON and bistable for three (low, medium and high) and two (low and high) parameters, representing the ...
Marco Montalva-Medel   +3 more
doaj   +1 more source

Attractor Stability in Finite Asynchronous Biological System Models [PDF]

open access: yesBulletin of Mathematical Biology 81.5 (2019): 1442-1460, 2022
We present mathematical techniques for exhaustive studies of long-term dynamics of asynchronous biological system models. Specifically, we extend the notion of $\kappa$-equivalence developed for graph dynamical systems to support systematic analysis of all possible attractor configurations that can be generated when varying the asynchronous update ...
arxiv   +1 more source

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