Finite state machine and Markovian equivalents of the lac Operon in E. coli bacterium
AIMS Bioengineering, 2022 The lac operon in E. coli has been extensively studied by computational biologists. The bacterium uses it to survive in the absence of glucose, utilizing lactose for growth.
Urooj Ainuddin, Maria Waqas
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Adaptive evolution of the lactose utilization network in experimentally evolved populations of Escherichia coli. [PDF]
PLoS Genetics, 2012 Adaptation to novel environments is often associated with changes in gene regulation. Nevertheless, few studies have been able both to identify the genetic basis of changes in regulation and to demonstrate why these changes are beneficial.
Selwyn Quan +6 more
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Delineating the Role of the msaABCR Operon in Staphylococcal Overflow Metabolism
Frontiers in Microbiology, 2022 Staphylococcus aureus is an important human pathogen that can infect almost every organ system, resulting in a high incidence of morbidity and mortality. The msaABCR operon is an important regulator of several staphylococcal phenotypes, including biofilm
Bibek G C +2 more
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Nonlinear fitness landscape of a molecular pathway. [PDF]
PLoS Genetics, 2011 Genes are regulated because their expression involves a fitness cost to the organism. The production of proteins by transcription and translation is a well-known cost factor, but the enzymatic activity of the proteins produced can also reduce fitness ...
Lilia Perfeito +4 more
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The Inducible lac Operator-Repressor System Is Functional in Zebrafish Cells
Frontiers in Genetics, 2021 BackgroundZebrafish are a foundational model organism for studying the spatio-temporal activity of genes and their regulatory sequences. A variety of approaches are currently available for editing genes and modifying gene expression in zebrafish ...
Sierra S. Nishizaki +8 more
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Concentration and Length Dependence of DNA Looping in Transcriptional Regulation [PDF]
, 2008 In many cases, transcriptional regulation involves the binding of transcription factors at sites on the DNA that are not immediately adjacent to the promoter of interest.
Beausang, John F. +6 more
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Supercoiling Effects on Short-Range DNA Looping in E. coli. [PDF]
PLoS ONE, 2016 DNA-protein loops can be essential for gene regulation. The Escherichia coli lactose (lac) operon is controlled by DNA-protein loops that have been studied for decades.
Lauren S Mogil +2 more
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Growth rate regulation of lac operon expression in Escherichia coli is cyclic AMP dependent [PDF]
, 2003 In contrast to the ribosomal RNA gene expression increasing with growth rate, transcription of the lac operon is downregulated by cell growth rate. In continuous culture, growth rate regulation of lac promoter was independent of carbon substrate used and
Botsford +37 more
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What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems [PDF]
, 2014 Multistable gene regulatory systems sustain different levels of gene expression under identical external conditions. Such multistability is used to encode phenotypic states in processes including nutrient uptake and persistence in bacteria, fate ...
Berg, Johannes +3 more
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Biochemical Society Transactions, 2019 The Escherichia coli lac operon promoter is widely used as a tool to control recombinant protein production in bacteria. Here, we give a brief review of how it functions, how it is regulated, and how, based on this knowledge, a suite of lac promoter ...
D. Browning +4 more
semanticscholar +1 more source