Results 31 to 40 of about 50,722 (240)

Identification of the Extracytoplasmic Function σ Factor σP Regulon in Bacillus thuringiensis

mSphere, 2022
Bacillus thuringiensis and other members of the Bacillus cereus family are resistant to many β-lactams. Resistance is dependent upon the extracytoplasmic function sigma factor σP.
Theresa D. Ho, Kelsie M. Nauta, Emma K. Luhmann, Lilliana Radoshevich, Craig D. Ellermeier   +4 more
doaj   +1 more source

Degradable Donor‐Acceptor Polymeric Mixed Ionic‐Electronic Conductors for Transient Electronics

Advanced Materials Technologies, EarlyView.
Here, we report degradable donor–acceptor (D–A) polymeric mixed ionic‐electronic conductors for transient electronics. We take a systematic side chain engineering approach to elucidate how molecular‐level modifications of donor–acceptor (D–A) polymer structures can satisfy demands that are often conflicting: degradability, charge carrier transport, and
Angela Lin, Zhichang Liu, Saroj Upreti, Stanley Lo, Nathan Sung Yuan Hsu, Xiaodan Gu, Sihong Wang, Helen Tran   +7 more
wiley   +1 more source

Covalent Protein Inhibitors via Tyrosine and Tryptophan Conjugation with Cyclic Imine Mannich Electrophiles

Angewandte Chemie, EarlyView.
Targeted covalent inhibitors (TCI) containing cyclic imine warheads react with tyrosine and tryptophan residues via the Mannich reaction. These cyclic imine warheads show comparable reaction kinetics to cysteine‐reactive electrophiles commonly used in TCIs.
Sijie Wang, Lei Wang, Marco Hadisurya, Siavash Shahbazi Nia, W. Andy Tao, Emily C. Dykhuizen, Casey J. Krusemark   +6 more
wiley   +2 more sources

Highly Resolved Community Sewage Metagenomics Unveiling Landscape and Transmission Patterns of Antibiotic Resistome in Hong Kong Populations

Advanced Science, EarlyView.
A large‐scale, high‐resolution antimicrobial resistance (AMR) surveillance in Hong Kong community sewage combining short‐ and long‐read sequencing. The resistome profile is comprehensively characterized, and this upstream sampling strategy demonstrated superiority in reflecting the human gut resistome.
Jiahui Ding, Mengying Wang, Xiaoqing Xu, Dou Wang, Xi Chen, Shuxian Li, Xiawan Zheng, You Che, Yu Deng, Tommy T. Y. Lam, Liguan Li, Tong Zhang   +11 more
wiley   +1 more source

Photochemical Cyclization of Tertiary Buta‐2,3‐dienamides to β‐Lactams Upon Triplet Energy Transfer

Angewandte Chemie, EarlyView.
Energy transfer is the key to the successful photocyclization of the title compounds to 3,4‐disubstituted 2‐azetidinones. If the substituent at the nitrogen atom is primary (R2 = H), trans products are formed exclusively. The triplet state of xanthen‐9‐one (XT) was found to be quenched by an allene amide (R, R2 = H, R1 = Bn, and R3 = Ph) with a ...
Johannes Hofer, Maria‐Sophie Bertrams, Christoph Kerzig, Thorsten Bach   +3 more
wiley   +2 more sources

Remarkable Iodine-Catalyzed Synthesis of Novel Pyrrole- Bearing N-Polyaromatic β-Lactams

Molecules, 2010
Because of their interesting biological properties various methods for the synthesis of substituted pyrroles are described in the literature. However, synthesis of pyrroles fused with a β-lactam ring has not been reported.
Bimal K. Banik, Hector Aguilar, Isabel Salinas, Gildardo Rivera, Debasish Bandyopadhyay   +4 more
doaj   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

β-Lactam Exposure Triggers Reactive Oxygen Species Formation in Enterococcus faecalis via the Respiratory Chain Component DMK

Cell Reports, 2019
Summary: Whereas the primary actions of β-lactams are well characterized, their downstream effects are less well understood. Although their targets are extracellular, β-lactams stimulate respiration in Escherichia coli leading to increased intracellular ...
Loïc Léger, Aurélie Budin-Verneuil, Margherita Cacaci, Abdellah Benachour, Axel Hartke, Nicolas Verneuil   +5 more
doaj   +1 more source

High‐Performance Ambipolar Organic Electrochemical Transistors Based on Diketopyrrolopyrrole‐Dialkoxybithiazole Conjugated Polymers for Single‐component Inverters

Advanced Science, EarlyView.
Two donor‐acceptor conjugated polymers, incorporating diketopyrrolopyrrole (DPP) and dialkoxybithiazole (2Tz) units with ethylene glycol (EG) side chains, exhibit relatively balanced ambipolar organic electrochemical transistor (OECT) performance. This ambipolarity enables the realization of single‐component complementary inverters capable of ternary ...
Jiazheng Li, Zhi Li, Jiayu Huang, Jingjing Su, Peijie Xu, Siwen Wang, Ping Zhang, Yuchuan Tian, Tao Pan, Junyang Liu, Junyu Li, Gang Ye, Ryan C. Chiechi, Yanxi Zhang, Wenjing Hong   +14 more
wiley   +1 more source

NEW SYNTHETIC APPROACH TO FUNCTIONALIZED α METHYLENE γ BUTYROLACTAMS. A NEW ACCESS TO β HYDROXYMETHYLATED MODELS OF HIGH SYNTHETIC POTENTIALITY

Scientific Study & Research: Chemistry & Chemical Engineering, Biotechnology, Food Industry, 2012
A new technique for the elaboration of α-methylene-γ-butyrolactams hydroxymethylated at the β-position has been developed. This new synthetic approach is based upon the preliminary assembly of N protected and γ-carboxylated analogues.
Gwenaëlle Liberge, Stéphane Lebrun, Axel Couture, Pierre Grandclaudon   +3 more
doaj