Journal of the Royal Anthropological Institute, EarlyView.Our understanding of the recolonization of northwest Europe in the period leading up to the Lateglacial Interstadial relies heavily on discoveries from Gough's Cave (Somerset, UK). Gough's Cave is the richest Late Upper Palaeolithic site in the British Isles, yielding an exceptional array of human remains, stone and organic artefacts, and butchered ...
Silvia M. Bello +2 more
wiley +1 more source
Scientific Reports, 2018 In humans the expression of lactase changes during post-natal development, leading to phenotypes known as lactase persistence and non-persistence. Polymorphisms within the lactase gene (LCT) enhancer, in particular the −13910C > T, but also others, are ...
Milena N. Leseva +6 more
doaj +1 more source
The cow’s milk allergy that wasn’t: allergy to supplemental oral lactase enzyme
Allergy, Asthma & Clinical Immunology, 2023 Background Allergy to supplemental lactase is sparsely reported in the literature with only one prior case of anaphylaxis documented [2]. Reactions to this agent can occur following cow’s milk ingestion which could lead to an erroneous diagnosis of cow’s
Sarah K. Lohrenz, A. Kanani
doaj +1 more source
Brush border digestion : development of a physiologically relevant in vitro model : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physiology at Massey University, Manawatū, New Zealand [PDF]
, 2018 Chapter Two has, in part, been published in the Springer publication, Reviews of Physiology, Biochemistry and Pharmacology, but the Author retains the right to publish the material in any collection consisting of the Author's own works: Hooton, D ...
Hooton, Diane Frances
core
Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change [PDF]
, 2016 The importance of subtle gene regulation and epigenetics in determining complex human traits is increasingly being recognized. However, bridging the gaps between environmental, epigenetic and genetic influences and unraveling causal relationships remain ...
Swallow, DM, Troelsen, JT
core +1 more source
Homo sapiens, industrialisation and the environmental mismatch hypothesis
Biological Reviews, EarlyView.ABSTRACT For the vast majority of the evolutionary history of Homo sapiens, a range of natural environments defined the parameters within which selection shaped human biology. Although human‐induced alterations to the terrestrial biosphere have been evident for over 10,000 years, the pace and scale of change has accelerated dramatically since the onset
Daniel P. Longman, Colin N. Shaw
wiley +1 more source
Pembrolizumab for Early‐Stage Triple‐Negative Breast Cancer: KEYNOTE‐522 Japan Subgroup Analysis
Cancer Science, EarlyView.In the global, phase 3 KEYNOTE‐522 study of high‐risk early‐stage triple‐negative breast cancer (TNBC), neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab improved efficacy outcomes versus neoadjuvant chemotherapy alone. In this analysis of Japanese participants from KEYNOTE‐522, neoadjuvant pembrolizumab plus chemotherapy ...
Masato Takahashi +16 more
wiley +1 more source
DIGESTIVE DISORDERS IN PREMATURELY BORN CHILDREN
Вопросы современной педиатрии, 2012 The article contains data on functional digestive disorders in newborns, mainly on the problem of lactase (disaccharidase) insufficiency. The information on the prevalence of this condition, modern classification of hypolactasia, diagnostic techniques ...
I. A. Belyaeva +2 more
doaj +1 more source
Association of lactase persistence genotype with milk consumption, obesity and blood pressure:a Mendelian randomization study in the 1982 Pelotas (Brazil) Birth Cohort with a systematic review and meta-analysis. [PDF]
, 2016 Background: Milk intake has been associated with lower blood pressure (BP) in observational studies, and randomized controlled trials suggested that milk-derived tripeptides have BP-lowering effects.
Davey Smith, George +4 more
core +2 more sources
Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review
International Journal of Dermatology, EarlyView.ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska +8 more
wiley +1 more source