Results 21 to 30 of about 778,516 (343)

ATP-Sensitive Potassium Channel-Mediated Lactate Effect on Orexin Neurons: Implications for Brain Energetics during Arousal [PDF]

, 2010
Active neurons have a high demand for energy substrate, which is thought to be mainly supplied as lactate by astrocytes. Heavy lactate dependence of neuronal activity suggests that there may be a mechanism that detects and controls lactate levels and/or ...
Hirasawa, Michiru, Parsons, Matthew P.
core   +1 more source

Effect of mevalonate, zoledronate and BCG on monocyte/macrophage phenotype

Сибирский научный медицинский журнал, 2023
Cells of innate immunity, mainly monocytes/macrophages, form a long-term nonspecific immunological memory during the initial encounter with the pathogen, the so-called trained immunity.
A. P. Lykov, S. N. Belogorodtsev, E. K. Nemkova, A. Vetlugina, T. M. Terekhova, Ya. Sh. Schwartz   +5 more
doaj   +1 more source

Lactylation in tumor: mechanisms and therapeutic potentials

Frontiers in Immunology
Lactate, a central product of glucose metabolism, plays a vital role in energy supply and signal transduction, and it also participates in gene transcription regulation through lactylation.
Dandan Wang, Hao Rong, Ke Ma, Jun Peng
doaj   +1 more source

Potential source of bias in AI models: lactate measurement in the ICU in sepsis patients as a template

Frontiers in Medicine
ObjectiveHealth inequities may be driven by demographics such as sex, language proficiency, and race-ethnicity. These disparities may manifest through likelihood of testing, which in turn can bias artificial intelligence models.
Pratiksha Pradhan, Pratiksha Pradhan, Fredrik Willumsen Haug, Fredrik Willumsen Haug, Nebal S. Abu Hussein, Nebal S. Abu Hussein, Dana Moukheiber, Lama Moukheiber, Mira Moukheiber, Sulaiman Moukheiber, Luca Leon Weishaupt, Jacob G. Ellen, Helen D'Couto, Ishan C. Williams, Leo Anthony Celi, Leo Anthony Celi, Leo Anthony Celi, Joao Matos, Joao Matos, Joao Matos, Tristan Struja, Tristan Struja, Tristan Struja   +22 more
doaj   +1 more source

The evolutionary rewiring of ubiquitination targets has reprogrammed the regulation of carbon assimilation in the pathogenic yeast Candida albicans [PDF]

, 2012
Date of Acceptance: 13/11/2012 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-ShareAlike 3.0 Unported license, which permits unrestricted noncommercial use, distribution, and reproduction in ...
Ashe, Atir-Lande, Barelle, Barford, Beckwith, Brown, Buchalter, Calderone, Carlson, Cline, Crabtree, de Nobel, Ene, Enjalbert, Enjalbert, Enjalbert, Entian, Fradin, Futcher, Gancedo, Gancedo, Gancedo, Garreau, Gounalaki, Gygi, Görner, Horak, Hämmerle, Ihmels, Imbeaud, Jacob, Janke, Jiang, Johnston, Kaniak, Knop, Kusch, Lavoie, Leach, Leach, Leng, Li, Lorenz, Lorenz, López-Boado, Martchenko, Mercado, Mercado, Mercado, Merico, Nantel, Niimi, Odds, Ozcan, Piekarska, Radivojac, Ramírez, Regelmann, Rodaki, Roig, Roig, Rolland, Sabina, Scheffler, Schüle, Sherman, Smith, Stanhill, Thevelein, Thewes, Trunk, Tsong, Ueno, Usaite, Walker, Yin, Yin, Yin, Yin   +78 more
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Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities

Cancer Biology & Medicine
Breast cancer (BC) has the highest prevalence among cancers specific to women, and its incidence rates are increasing in many countries. Subtypes of BC, including HER2-positive or triple-negative BC, exhibit differing treatment responses; consequently ...
Lan Huang, Xuemei Chen, Meina Yan, Ze Xiang, Jian Wu   +4 more
doaj   +1 more source

Sympathy Lactation [PDF]

Journal of Perinatal Education, 2009
In this humor column, a childbirth educator describes assisting a parent and her young children with boarding an airplane.
openaire   +2 more sources

The physiological and mechanical demands of aerobics, indoor cycling, and netball in recreationally active females [PDF]

, 2019
Background Group-based exercise is a popular method of improving fitness. However, limited research exists on the mul- tidisciplinary responses to group-based exercise. Aims The aim of this study was to compare the physiological and mechanical demands of
GREIG, MATT, MARRIN, KELLY, MCIVER, VICTORIA   +2 more
core   +2 more sources

Research progress on the interaction between glucose metabolic reprogramming and lactylation in tumors

Frontiers in Immunology
Glucose metabolic reprogramming describes the alterations in intracellular metabolic pathways in response to variations in the body’s internal environment. This metabolic reprogramming has been the subject of extensive research.
Yi Yang, Yi Yang, Yi Wu, Yi Wu, Hui Chen, Hui Chen, Zehai Xu, Zehai Xu, Ruisi Lu, Ruisi Lu, Sijie Zhang, Sijie Zhang, Rui Zhan, Rui Zhan, Qinghua Xi, Qinghua Xi, Yunfeng Jin, Yunfeng Jin   +17 more
doaj   +1 more source

Evaluation of Clinical and Laboratory Prognostic Risk Factors in Organophosphate or Carbamate-Poisoned Pediatric Patients

Eurasian Journal of Emergency Medicine, 2021
Aim:We aimed to determine the clinical and demographic features of pediatric patients monitored at our hospital after organophosphate or carbamate intoxication.
Mehmet Açıkgöz
doaj   +1 more source