Results 41 to 50 of about 778,516 (343)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Modeling Challenge Data to Quantify Endogenous Lactate Production

Frontiers in Endocrinology, 2021
With the intention of isolating the susceptibility of modeling methodology to influence our investigation of the infusion data, we used three kinetic approaches to our models: a simple approach, a unit approach, and a novel approach.
Darko Stefanovski, Pamela A. Wilkins, Raymond C. Boston   +2 more
doaj   +1 more source

“Lactate Shift,” Rather Than “Lactate Clearance,” for Serial Blood Lactate Monitoring?

Critical Care Medicine, 2015
To the Editor:We read with interest the letter to the editor by Dr. Vincent (1) citing our work (2) on blood lactate in patients with sepsis admitted to intensive care, and we broadly agree with the points he raised.
Walker, Craig, Griffith, David, Gray, Alasdair, Datta, Deepankar, Hay, Alastair   +4 more
openaire   +3 more sources

Metabolic and Stress Responses in Senegalese Soles (Solea senegalensis Kaup) Fed Tryptophan Supplements: E ects of Concentration and Feeding Period [PDF]

, 2019
The objective of this study was to assess the impact of di erent dietary Trp concentrations on the stress and metabolism response of juvenile Senegalese soles (Solea senegalensis). Fish (38.1 1.9 g) were fed di erent Trp-enriched feeds (0%, 1% and 2%
Giráldez, Inmaculada, Herrera, Marcelino, López, Jose R., Mancera Romero, Juan Miguel, Martos Sitcha, Juan Antonio, Miró, Juan M., Salamanca, Natalia   +6 more
core   +4 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

The diagnostic accuracy of different fetal blood sample lactate cutoffs in labor, utilizing the StatStrip Xpress® lactate‐meter: A population‐based observational study

Acta Obstetricia et Gynecologica Scandinavica
Introduction A recent study recommended 5.2 mmol/L as a cutoff for fetal blood sample (FBS) lactate in labor for the StatStrip Lactate®/Lactate Xpress® lactate meter.
Magnus B. Berge, Jørg Kessler, Anne Cathrine Staff, Anne Flem Jacobsen   +3 more
doaj   +1 more source

A Rapid Increase in Serum Lactate Levels after Cardiovascular Surgery Is Associated with Postoperative Serious Adverse Events: A Single Center Retrospective Study

Diagnostics
Background/Objectives: Hyperlactatemia is a common predictive factor for poor post-cardiovascular surgery outcomes. However, it is not well understood whether the rapid postoperative lactate level elevation in a short period of time is associated with ...
Kenichiro Kikuchi, Satoshi Kazuma, Yoshiki Masuda   +2 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Regulatory role and therapeutic prospect of lactate modification in cancer

Frontiers in Pharmacology
Post-translational modifications (PTMs) of proteins refer to the process of adding chemical groups, sugars, or other molecules to specific residues of target proteins following their biosynthesis by ribosomes.
Mengdi Sun, Kejing Wang, Fang Lu, Donghua Yu, Shumin Liu   +4 more
doaj   +1 more source

Lactation Curves for First Lactation Egyptian Buffalo

Journal of Dairy Science, 1994
First lactation records of 1538 buffalo maintained at the Animal Production Research Institute farms in 1967 to 1990 were used to determine lactation curves for three lactation lengths: > 28 and < 150 d, > 149 d, and > or = 308 d, as well as all records. Daily milk yields were summed by 14-d intervals for analyses.
G H, Metry, K A, Mourad, J C, Wilk, B T, McDaniel   +3 more
openaire   +2 more sources