Results 41 to 50 of about 774,319 (342)

Blood lactate clearance after maximal exercise depends on active recovery intensity [PDF]

open access: yes, 2014
AIM: High-intensity exercise is time-limited by onset of fatigue, marked by accumulation of blood lactate. This is accentuated at maximal, all-out exercise that rapidly accumulates high blood lactate.
Devlin, J.   +6 more
core  

Production processes of fermented organic acids targeted around membrane operations: design of the concentration step by conventional electrodialysis [PDF]

open access: yes, 2001
Organic acids are increasingly used for various industrial applications. Their production is mainly achieved by fermentation. Precipitation or extraction stages, which generate big amount of effluents, are then traditionally used to get the acid in a ...
Aimar, Pierre   +4 more
core   +3 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Direct and indirect lactate oxidation in trained and untrained men. [PDF]

open access: yes, 2013
Lactate has been shown to be an important oxidative fuel. We aimed to quantify the total lactate oxidation rate (Rox) and its direct vs. indirect (glucose that is gluconeogenically derived from lactate and subsequently oxidized) components (mg·kg(-1)·min(
Brooks, George A   +5 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis [PDF]

open access: yes, 2005
Introduction: Acute metabolic acidosis of non-renal origin is usually a result of either lactic or ketoacidosis, both of which are associated with a high anion gap.
Forni, L.G.   +5 more
core   +2 more sources

Strength through diversity: how cancers thrive when clones cooperate

open access: yesMolecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken   +3 more
wiley   +1 more source

The Significance of Blood and Peritoneal Fluid Biochemical Markers in Identifying Early Anastomotic Leak following Colorectal Resection—Findings from a Single-Center Study

open access: yesMedicina, 2022
Background and Objectives: The aim of our study was to evaluate the value of leukocyte, C reactive protein (CRP), procalcitonin, lactate, and carcinoembryonic antigen (CEA) in blood and peritoneal fluid in early recognition of anastomotic leak (AL) after
Jurij Janež   +3 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

“Lactate Shift,” Rather Than “Lactate Clearance,” for Serial Blood Lactate Monitoring?

open access: yesCritical Care Medicine, 2015
To the Editor:We read with interest the letter to the editor by Dr. Vincent (1) citing our work (2) on blood lactate in patients with sepsis admitted to intensive care, and we broadly agree with the points he raised.
Walker, Craig   +4 more
openaire   +3 more sources

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