Results 1 to 10 of about 1,327 (89)
Saudi Pharmaceutical Journal, 2022 Linezolid is an oxazolidinone antibiotic. Linezolid-associated lactic acidosis has been reported in 6.8% of linezolid-treated patients. Lactic acidosis is associated with poor clinical outcomes, with high blood lactate levels resulting in organ ...
Naiju Zhang +5 more
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The genomic analysis of lactic acidosis and acidosis response in human cancers. [PDF]
PLoS Genetics, 2008 The tumor microenvironment has a significant impact on tumor development. Two important determinants in this environment are hypoxia and lactic acidosis.
Julia Ling-Yu Chen +8 more
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Kidney International, 1986 Lactic acidosis is a metabolic disturbance characterized by an increase of the production/clearance ratio of lactate. Lactate is a catabolite of glycolysis when this takes place under anaerobic conditions. Clinically LA is characterized by: signs of acidosis, venous blood lactate greater than 5 mMol/l, arterial pH less than 7.25.
MOLINATTI GM +3 more
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Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. [PDF]
PLoS Genetics, 2010 Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional responses of breast cancer
Julia Ling-Yu Chen +9 more
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Type B Lactic Acidosis in A Child with Relapsed non-Hodgkin Lymphoma
Journal of Pediatric Emergency and Intensive Care Medicine, 2023 Lactic acidosis is a major cause of metabolic acidosis in critically ill patients. Herein we report a child with relapsed non-Hodgkin’s lymphoma admitted to the pediatric intensive care unit (PICU) with profound lactic acidosis.
Tolga Besci +5 more
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Scientific Reports, 2020 Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis. Acidosis and lactic acidosis can induce different responses in tumors. Previous
Jiayue Gao +8 more
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New England Journal of Medicine, 2014 Lactic acidosis results from the accumulation of lactate and protons in the body fluids and is often associated with poor clinical outcomes. The effect of lactic acidosis is governed by its severity and the clinical context. Mortality is increased by a factor of nearly three when lactic acidosis accompanies low-flow states or sepsis,1 and the higher ...
Ingelfinger, Julie R +2 more
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BMC Endocrine Disorders, 2022 Background Mitochondrial ribosomal protein S2 (MRPS2) gene mutation, which is related to severe hypoglycemia and lactic acidosis, is rarely reported globally. Case presentation We report a case of a new MRPS2 gene mutation in a Chinese girl who presented
ChangZhi Liu +3 more
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Etiology of lactic acidosis in malaria.
PLoS Pathogens, 2021 Lactic acidosis and hyperlactatemia are common metabolic disturbances in patients with severe malaria. Lactic acidosis causes physiological adverse effects, which can aggravate the outcome of malaria.
Hendrik Possemiers +2 more
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Type B Lactic Acidosis in a Patient with Mantle Cell Lymphoma
Case Reports in Critical Care, 2023 Type B lactic acidosis is an uncommon medical emergency in which acid production overwhelms hepatic clearance. This specific etiology of lactic acidosis occurs without organ hypoperfusion and has been most commonly described in patients with hematologic ...
Ikemsinachi C. Nzenwa +12 more
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