Results 11 to 20 of about 288,915 (310)
Etiology of lactic acidosis in malaria.
PLoS Pathogens, 2021 Lactic acidosis and hyperlactatemia are common metabolic disturbances in patients with severe malaria. Lactic acidosis causes physiological adverse effects, which can aggravate the outcome of malaria.
Hendrik Possemiers +2 more
doaj +2 more sources
Scientific Reports, 2020 Extracellular acidosis is considered as a hallmark of most human tumors, which plays an important role in promoting tumor malignant and aggressive phenotype in tumorigenesis. Acidosis and lactic acidosis can induce different responses in tumors. Previous
Jiayue Gao +8 more
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Type B lactic acidosis associated with diffuse large B-cell lymphoma and the Warburg effect
Journal of International Medical Research, 2022 Type B lactic acidosis is a rare complication of non-tissue perfusion abnormalities caused by solid tumors or hematologic malignancies. Herein, we present the case of a 42-year-old man with type B lactic acidosis and hypoglycemia who was found to have a ...
Chunhua Wang, Zanmei Lv, Yanwei Zhang
doaj +2 more sources
Journal of Medical Case Reports, 2019 Background Metformin has been widely used as a first-line agent to treat type 2 diabetes mellitus. Lactic acidosis is a rare but serious adverse effect in patients treated with metformin.
Hiroki Kinoshita +4 more
doaj +2 more sources
Diabetes mellitus: Complex interplay between metformin, AKI and lactic acidosis. [PDF]
Nature Reviews Nephrology, 2017 Debate exists regarding the safety of metformin and the risk of metformin-associated lactic acidosis, particularly in the setting of kidney dysfunction.
Kalantar-Zadeh, Kamyar, Rhee, Connie M
core +2 more sources
Pyruvate is a prospective alkalizer to correct hypoxic lactic acidosis
Military Medical Research, 2018 Type A lactic acidosis resulted from hypoxic mitochondrial dysfunction is an independent predictor of mortality for critically ill patients. However, current therapeutic agents are still in shortage and can even be harmful.
Ying Wang +5 more
doaj +2 more sources
Cancers, 2023 Simple Summary Lactic acidosis is a prominent feature of the tumour microenvironment and a key player in cancer metabolism. This review is aimed at combining the mechanisms through which lactic acidosis alters the metabolism of cancer cells, and ...
Zoé Daverio +3 more
semanticscholar +1 more source
Lactic Acidosis Related to Pharmacotherapy and Human Diseases
Pharmaceuticals, 2022 Lactic acidosis represents one of the most common conditions that can compromise the health of intensive care unit (ICU) patients, increasing the mortality of patients with high levels of Lactate who do not receive a proper treatment within the first 6 h
C. Zanza +10 more
semanticscholar +1 more source
Metformin: When Should We Fear Lactic Acidosis?
International Journal of Molecular Sciences, 2022 Metformin, a molecule belonging to the biguanide family, represents one of the most commonly prescribed medications for the treatment of diabetes mellitus in the world. Over the sixty years during which it has been used, many benefits have been described,
S. Di Mauro +5 more
semanticscholar +1 more source
Nature Communications, 2021 Lactic acidosis, the extracellular accumulation of lactate and protons, is a consequence of increased glycolysis triggered by insufficient oxygen supply to tissues.
C. Adam +14 more
semanticscholar +1 more source