Results 91 to 100 of about 4,363 (213)

YTNP LACTONASE IMPROVES THE ABILITY OF CAENORHABDITIS ELEGANS TO SURVIVE PSEUDOMONAS AERUGINOSA MMA83 INFECTION [PDF]

Pseudomonas aeruginosa is a Gram-negative pathogen responsible for frequent hospital-acquired infections of the bloodstream, the respiratory tract, and the urinary tract.
Ćurčić, Jovana, Jovčić, Branko, Vasiljević, Zorica, Stanisavljević, Nemanja, Malešević, Milka, Dinić, Miroslav, Novović, Katarina   +6 more
core  

Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426.

PLoS ONE, 2015
Enzyme promiscuity is a prerequisite for fast divergent evolution of biocatalysts. A phosphotriesterase-like lactonase (PLL) from Geobacillus kaustophilus HTA426 (GkaP) exhibits main lactonase and promiscuous phosphotriesterase activities.
Yu Zhang, Jiao An, Guang-Yu Yang, Aixi Bai, Baisong Zheng, Zhiyong Lou, Geng Wu, Wei Ye, Hai-Feng Chen, Yan Feng, Giuseppe Manco   +10 more
doaj   +1 more source

Unraveling the role of UilS, a urea-induced acyl-homoserine lactonase that enhances Serratia marcescens fitness, interbacterial competition, and urinary tract infection

mBio
Serratia marcescens, a member of the Enterobacteriaceae family, is an opportunistic human pathogen and a frequent cause of urinary tract infections. Clinical isolates often exhibit resistance to multiple antibiotics, posing challenges for successful ...
Marisel R. Tuttobene, Brayan S. Arango Gil, Gisela Di Venanzio, Javier F. Mariscotti, Rodrigo Sieira, Mario F. Feldman, María Soledad Ramirez, Eleonora García Véscovi   +7 more
doaj   +1 more source

Characterization of a Novel N-Acylhomoserine Lactonase RmmL from Ruegeria mobilis YJ3

Marine Drugs, 2018
Gram-negative bacteria utilize N-acylhomoserine lactones (AHLs) as quorum sensing (QS) signaling molecules for intercellular communication. Cell-to-cell communication depends on cell population density, and AHL-dependent QS is related to the production ...
Xiulei Cai, Min Yu, Hu Shan, Xiaorong Tian, Yanfen Zheng, Chunxu Xue, Xiao-Hua Zhang   +6 more
doaj   +1 more source

MzmL, a novel marine derived N-acyl homoserine lactonase from Mesoflavibacter zeaxanthinifaciens that attenuates Pectobacterium carotovorum subsp. carotovorum virulence

Frontiers in Microbiology
Quorum sensing (QS) is a conserved cell–cell communication mechanism widely distributed in bacteria, and is oftentimes tightly correlated with pathogen virulence.
Lingyun Hao, Jinyou Liang, Shuotian Chen, Junliang Zhang, Yu Zhang, Ying Xu   +5 more
doaj   +1 more source

Directed Evolution of a Quorum-Quenching Lactonase from Mycobacterium avium subsp. paratuberculosis K-10 in the Amidohydrolase Superfamily

, 2016
The PLL(PTE-like lactonase)-group of enzymes within the amidohydrolase superfamily hydrolyze N-acyl-homoserine lactones (AHLs) that are involved in bacterial quorum-sensing pathways.
Jeng Yeong Chow (1574587), Long Wu (655081), Wen Shan Yew (605866)   +2 more
core   +1 more source

Characterization of AiiK, an AHL lactonase, from Kurthia huakui LAM0618T and its application in quorum quenching on Pseudomonas aeruginosa PAO1

Scientific Reports, 2018
N-Acyl homoserine lactones (AHLs) act as the key quorum sensing (QS) signal molecules in gram-negative bacteria, which coordinates gene expression and then activates various processes, including biofilm formation and production of virulence factors in ...
Weiwei Dong, Jie Zhu, Xiang Guo, Delong Kong, Qi Zhang, Yiqing Zhou, Xiaoyang Liu, Shumiao Zhao, Zhiyong Ruan   +8 more
doaj   +1 more source

The Human Paraoxonase 2: An Optimized Procedure for Refolding and Stabilization Facilitates Enzyme Analyses and a Proteomics Approach

Molecules
The human paraoxonase 2 (PON2) is the oldest member of a small family of arylesterase and lactonase enzymes, representing the first line of defense against bacterial infections and having a major role in ROS-associated diseases such as cancer ...
Eros A. Lampitella, Maria Marone, Nagendra S. K. Achanta, Elena Porzio, Francesco Trepiccione, Giuseppe Manco   +5 more
doaj   +1 more source

Purification and antibiofilm activity of ahl-lactonase from endophytic enterobacter aerogenes vt66

, 2015
The opportunistic pathogen Pseudomonas aeruginosa uses biofilm lifestyle to resist antibiotic treatment. In our study, endophytic bacterium Enterobacter aerogenes VT66 quenched the N-acyl homoserine lactone (AHL) molecules produced by P. aeruginosa PAO1.
Rajesh, P. S., Rai, V. Ravishankar
core  

Corrigendum: Signal Disruption Leads to Changes in Bacterial Community Population

Frontiers in Microbiology, 2021
Michael Schwab, Michael Schwab, Celine Bergonzi, Celine Bergonzi, Jonathan Sakkos, Christopher Staley, Christopher Staley, Qian Zhang, Qian Zhang, Michael J. Sadowsky, Michael J. Sadowsky, Michael J. Sadowsky, Alptekin Aksan, Alptekin Aksan, Mikael Elias, Mikael Elias   +15 more
doaj   +1 more source