Results 81 to 90 of about 4,209 (153)

Active site loop conformation regulates promiscuous activity in a lactonase from Geobacillus kaustophilus HTA426.

PLoS ONE, 2015
Enzyme promiscuity is a prerequisite for fast divergent evolution of biocatalysts. A phosphotriesterase-like lactonase (PLL) from Geobacillus kaustophilus HTA426 (GkaP) exhibits main lactonase and promiscuous phosphotriesterase activities.
Yu Zhang, Jiao An, Guang-Yu Yang, Aixi Bai, Baisong Zheng, Zhiyong Lou, Geng Wu, Wei Ye, Hai-Feng Chen, Yan Feng, Giuseppe Manco   +10 more
doaj   +1 more source

Insights into the Lactonase Mechanism of Serum Paraoxonase 1 (PON1): Experimental and Quantum Mechanics/Molecular Mechanics (QM/MM) Studies

, 2015
Serum paraoxonase 1 (PON1) is a versatile enzyme for the hydrolysis of various substrates (e.g., lactones, phosphotriesters) and for the formation of a promising chemical platform gamma-valerolactone.
Kim, Yong Hwan, Chang, Rakwoo, Seonghoon Kim (1559083), Le, Quang Anh Tuan, Kim, Seonghoon, Rakwoo Chang (1559080), Yong Hwan Kim (411929), Quang Anh Tuan Le (1559086)   +7 more
core   +1 more source

Unraveling the role of UilS, a urea-induced acyl-homoserine lactonase that enhances Serratia marcescens fitness, interbacterial competition, and urinary tract infection

mBio
Serratia marcescens, a member of the Enterobacteriaceae family, is an opportunistic human pathogen and a frequent cause of urinary tract infections. Clinical isolates often exhibit resistance to multiple antibiotics, posing challenges for successful ...
Marisel R. Tuttobene, Brayan S. Arango Gil, Gisela Di Venanzio, Javier F. Mariscotti, Rodrigo Sieira, Mario F. Feldman, María Soledad Ramirez, Eleonora García Véscovi   +7 more
doaj   +1 more source

MzmL, a novel marine derived N-acyl homoserine lactonase from Mesoflavibacter zeaxanthinifaciens that attenuates Pectobacterium carotovorum subsp. carotovorum virulence

Frontiers in Microbiology
Quorum sensing (QS) is a conserved cell–cell communication mechanism widely distributed in bacteria, and is oftentimes tightly correlated with pathogen virulence.
Lingyun Hao, Jinyou Liang, Shuotian Chen, Junliang Zhang, Yu Zhang, Ying Xu   +5 more
doaj   +1 more source

A mesophilic phosphotriesterase-like lactonase shows high stability and proficiency as quorum quenching enzyme

, 2023
The problem of biofilm formation is a serious concern under various pathological conditions such as extensive burns, wounds in diabetic patients, bedsores, cystic fibrosis, nosocomial infections from implantable medical devices such as catheters, valves,
Giuseppe Manco, Elena Porzio, Maria Marone, Eros Antonio Lampitella   +3 more
core  

The Human Paraoxonase 2: An Optimized Procedure for Refolding and Stabilization Facilitates Enzyme Analyses and a Proteomics Approach

Molecules
The human paraoxonase 2 (PON2) is the oldest member of a small family of arylesterase and lactonase enzymes, representing the first line of defense against bacterial infections and having a major role in ROS-associated diseases such as cancer ...
Eros A. Lampitella, Maria Marone, Nagendra S. K. Achanta, Elena Porzio, Francesco Trepiccione, Giuseppe Manco   +5 more
doaj   +1 more source

Expression of N-acylhomoserine lactone lactonase genes in Arabidopsis thaliana

, 2015
In Gram-negative bacteria, N-acyl homoserine lactones (AHLs) are the key signalling molecules to sense the population density in a phenomenon coined as quorum sensing (QS), or simply known as cell-to-cell communication (Williams et al., 2000).
Husna Zayadi
core  

Enzymes with phosphotriesterase and lactonase activities in Archaea.

, 2008
Organophosphates (OPs) are a class of synthetic compounds used both as pesticides and nerve agents. They are chemically phosphoesters and biologically potent irreversible inhibitors of serine esterases, particularly acetylcholinesterase (ACh), the key ...
Merone L, Mandrich L, Rossi M, Manco G
core  

Labrenzia sp. BM1: A Quorum Quenching Bacterium That Degrades N-acyl Homoserine Lactones via Lactonase Activity

, 2014
We report the degradation of quorum sensing N-acylhomoserine lactone molecules by a bacterium isolated from a Malaysian marine water sample. MALDI-TOF and phylogenetic analysis indicated this isolate BM1 clustered closely to Labrenzia sp.
Kok-Gan Chan, Norshazliza Ghani, Siti Nur Maisarah Norizan, Xin Yue Chan, Siti Norizan, Xin Chan, Wai-Fong Yin, Norshazliza Ab Ghani   +7 more
core   +1 more source

Corrigendum: Signal Disruption Leads to Changes in Bacterial Community Population

Frontiers in Microbiology, 2021
Michael Schwab, Michael Schwab, Celine Bergonzi, Celine Bergonzi, Jonathan Sakkos, Christopher Staley, Christopher Staley, Qian Zhang, Qian Zhang, Michael J. Sadowsky, Michael J. Sadowsky, Michael J. Sadowsky, Alptekin Aksan, Alptekin Aksan, Mikael Elias, Mikael Elias   +15 more
doaj   +1 more source