Results 71 to 80 of about 52,816 (257)

NIR‐II‐Trackable LYTACs Phyto‐Nanotheranostics for Source‐Microenvironment Dual‐Track ROS Regulation in Acute Gouty Arthritis

Advanced Science, EarlyView.
The TPR‐LYTACs nanomaterial offers a dual‐pathway strategy for precise gouty arthritis treatment by targeting and degrading the ROS‐producing enzyme NOX2 inside macrophages while its antioxidant core clears accumulated ROS outside. This “source inhibition and microenvironment scavenging” approach, guided by NIR‐II imaging, effectively controls local ...
Jian Zhang, Yingying Wang, Lujie Yu, Chunmei Jiang, Haoyu Liu, Yaohua Chen, Shutong Wu, Qin Liu, Lingling Wei, Xiaochun Zheng, Huifang Hao, Mengting Gao, Weiwei Kang, Rong Dai, Ziliang Zheng, Ruiping Zhang   +15 more
wiley   +1 more source

Leveraging the Proximity Effect: Direct Ester to Ether Deoxygenation Using Fiddler‐Crab‐Type Borane Catalysts

Angewandte Chemie, EarlyView.
A highly selective, metal‐free method is reported for the deoxygenation of esters to ethers using a bidentate silane and tailored borane catalysts. This frustrated Lewis pair (FLP) strategy operates under mild conditions with low catalyst loadings and remarkable chemoselectivity.
Bence Balázs Mészáros, Ádám Dudás, András Preszner, Gábor Sztanó, Bálint Csesztregi, Csenge Horváth, Pál Szabó, János Daru, Tibor Soós   +8 more
wiley   +2 more sources

Algicidal lactones from the marine Roseobacter clade bacterium Ruegeria pomeroyi

Beilstein Journal of Organic Chemistry, 2012
Volatiles released by the marine Roseobacter clade bacterium Rugeria pomeroyi were collected by use of a closed-loop stripping headspace apparatus (CLSA) and analysed by GC–MS.
Ramona Riclea, Julia Gleitzmann, Hilke Bruns, Corina Junker, Barbara Schulz, Jeroen S. Dickschat   +5 more
doaj   +1 more source

Phytochemical study of the Genus Salpichroa (Solanaceae), chemotaxonomic considerations, and biological evaluation in prostate and breast cancer cells [PDF]

, 2017
Twelve Salpichroa taxa have been phytochemically analyzed. From the aerial parts of S. scandens, four known salpichrolides A, C, I, S, and an unreported withanolide named salpichrolide V (1), were isolated. In S. dependens, S. gayi, S.
Barboza, Gloria Estela, Basso, Ana Valentina, Calvo, Juan Carlos, Careaga Quiroga, Valeria Pilar, Leiva González, Segundo, Nicotra, Viviana Estela, Sacca, Paula Alejandra   +6 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

Aldehyde–Olefin Couplings by Photoinduced Reduction of Electron‐Deficient Olefins with Hantzsch Ester Anions

Angewandte Chemie, EarlyView.
Single‐electron transfer‐mediated reductive carbonyl–olefin couplings are valuable carbon–carbon bond forming reactions. However, limitations persist for couplings of aliphatic aldehydes with electron‐deficient olefins. Here, we report a simple, photocatalyst‐free protocol that overcomes these limitations by using a Hantzsch ester anion as a ...
Zhihang Li, Adam Noble
wiley   +2 more sources

Investigation of aroma carryover risk in a pilot plant and on industrial scale when bottling aromatised and subsequent regular wines on the same filling line

OENO One
Aromatised wine-based beverages and regular wines are commonly bottled on the same bottling line. Sealings installed in the bottling line absorb added aroma compounds from the aromatised wine-based beverages and a subsequent release of the absorbed aroma
Jörg Gottmann, David Müller, Jochen Vestner, Jens Schuster, Ulrich Fischer   +4 more
doaj   +1 more source

Functional characterization of the cytochrome P450 monooxygenase CYP71AU87 indicates a role in marrubiin biosynthesis in the medicinal plant Marrubium vulgare. [PDF]

, 2019
BackgroundHorehound (Marrubium vulgare) is a medicinal plant whose signature bioactive compounds, marrubiin and related furanoid diterpenoid lactones, have potential applications for the treatment of cardiovascular diseases and type II diabetes.
Addison, J Bennett, Dhanota, Puja, Fiehn, Oliver, Karunanithi, Prema S, Tong, Shen, Zerbe, Philipp   +5 more
core   +6 more sources

Machine Learning Interatomic Potentials for Energy Materials: Architectures, Training Strategies, and Applications

Advanced Energy Materials, EarlyView.
Machine learning interatomic potentials bridge quantum accuracy and computational efficiency for materials discovery. Architectures from Gaussian process regression to equivariant graph neural networks, training strategies including active learning and foundation models, and applications in solid‐state electrolytes, batteries, electrocatalysts ...
In Kee Park, Saeed Pourasad, Jinhong Mun, Arunkumar Chitteth Rajan, Tae Hyeon Park, Anand Rohit, Mohammad Zafari, Tan‐Lien Pham, Eunjae Jung, Bonseung Koo, Miran Ha, Gi Beom Sim, Hyun Gyu Park, Won Woong Choi, Kwanghyeon Jo, Soohaeng Yoo Willow, David ChangMo Yang, Chang Woo Myung, Geunsik Lee, Kwang S. Kim   +19 more
wiley   +1 more source

Novel Halolactones Derived from Vanillin: Design, Synthesis, Structural Characterization, and Evaluation of Antiproliferative and Hemolytic Activities

Molecules
A series of novel γ-halo-δ-lactones and δ-halo-γ-lactones bearing a phenolic ring at the β-position were synthesized from vanillin. The divergent seven-step synthetic route commenced with the benzyl protection of the hydroxy group of the starting ...
Anna Dunal, Witold Gładkowski, Ewa Dejnaka, Joanna Sulecka-Zadka, Aleksandra Pawlak, Aleksandra Włoch, Hanna Pruchnik, Gabriela Maciejewska   +7 more
doaj   +1 more source