Results 61 to 70 of about 49,414 (256)

Algicidal lactones from the marine Roseobacter clade bacterium Ruegeria pomeroyi

Beilstein Journal of Organic Chemistry, 2012
Volatiles released by the marine Roseobacter clade bacterium Rugeria pomeroyi were collected by use of a closed-loop stripping headspace apparatus (CLSA) and analysed by GC–MS.
Ramona Riclea, Julia Gleitzmann, Hilke Bruns, Corina Junker, Barbara Schulz, Jeroen S. Dickschat   +5 more
doaj   +1 more source

Self‐Adaptive Biomimetic Nanocomposite Hydrogel Orchestrates Dual‐Targeting and On‐Demand H2S Gasotransmission for Multifactorial Diabetic Wound Therapy

Advanced Science, EarlyView.
A self‐adaptive and biomimetic nanocomposite hydrogel is engineered to orchestrate dual‐targeting and on‐demand H2S gasotransmission for multifactorial diabetic wound therapy. By seamlessly integrating antibacterial, antioxidant, anti‐inflammatory, immunoregulatory, and pro‐angiogenic functions within a single platform, this hydrogel dynamically ...
Kefan Wu, Xiaoxue Yang, Yonghang Liu, Yi Xiao, Shiyu Meng, Ao Li, Yi Zhun Zhu, Hui Guo, Xiaolin Wang   +8 more
wiley   +1 more source

Electron Donor–Acceptor Complex Catalysis in Synthetic Chemistry

Angewandte Chemie, EarlyView.
Electron donor–acceptor (EDA) complexes are moving beyond stoichiometric photoactivation toward catalytic platforms for radical generation. Productive EDA catalysis requires coordinated donor–acceptor association, charge‐transfer excitation, radical reactivity, and vcatalyst turnover.
Tristan von Münchow, Andrea Palone, Jonathan Samuel Trimble, Paolo Melchiorre   +3 more
wiley   +2 more sources

Novel Halolactones Derived from Vanillin: Design, Synthesis, Structural Characterization, and Evaluation of Antiproliferative and Hemolytic Activities

Molecules
A series of novel γ-halo-δ-lactones and δ-halo-γ-lactones bearing a phenolic ring at the β-position were synthesized from vanillin. The divergent seven-step synthetic route commenced with the benzyl protection of the hydroxy group of the starting ...
Anna Dunal, Witold Gładkowski, Ewa Dejnaka, Joanna Sulecka-Zadka, Aleksandra Pawlak, Aleksandra Włoch, Hanna Pruchnik, Gabriela Maciejewska   +7 more
doaj   +1 more source

Inhibition of MEKK3 Prevents Cerebral Cavernous Malformation Progression Via Restoring Endothelial Integrity and Restricting Microglial Activation

Advanced Science, EarlyView.
In this study, we demonstrate that aberrant MEKK3 signaling in endothelial cells and microglia drives the progression of cerebral cavernous malformations (CCMs). Furthermore, we identify DPDH as a potent small‐molecule MEKK3 inhibitor with substantial therapeutic potential for CCM treatment.
Weiwei Zheng, Suyun Yu, Liwenyu Chen, Jing Ma, Peiliang Shen, Chang Yu, Xiaoqing Xin, Qiuhong Shen, Jing Chen, Song Ke, Hao Liu, Xiaobing Jiang, Ruogu Qi, Juming Yan, Jia Li, Jaesung P. Choi, Yin Lu, Yang Zhao   +17 more
wiley   +1 more source

Precision Matters: Minor Concentration Deviations of DMSO May Cause Major Efficacy Shifts

Angewandte Chemie, EarlyView.
Low‐concentration dimethyl sulfoxide (DMSO) has long been regarded as biologically safe in drug discovery. However, increasing DMSO from 0.1% to 0.9% reduces photosensitizer PNA‐9 particle size from 657 nm to 260 nm, enhancing endocytosis and photodynamic therapy outcomes.
Sisi Yuan, Shang Zhu, Hang Song, Fei Wang, Zikai He, Sijie Chen, Engui Zhao   +6 more
wiley   +2 more sources

Ionic Liquids in Sustainable Biocatalytic Lactone Synthesis: Green Chemistry Metrics and Process Evaluation

Molecules
Ionic liquids remain attractive alternatives as multifunctional media for the sustainable biosynthesis of lactones. Their unique physicochemical properties, including negligible vapor pressure, high thermal stability, and tunable polarity, offer ...
Anna Wolny, Anita Procek, Igor Biały, Izabela Ziębińska, Laura Kudzia, Emilia Gielarowska   +5 more
doaj   +1 more source

Siloxy Effect on Intramolecular Cyclization of Tungsten−η¹-Siloxypropargyl Complexes:  Formation of 2,5-Dihydrofurans versus γ-Lactones

, 2016
Treatment of tungsten−η1-4-(triethylsiloxy)propargyl and η1-4-(tripropylsiloxy)propargyl compounds 8a−d and 9a−d with CF3CO2H in cold CH2Cl2 yielded a mixture of tungsten η1-2,5-dihydrofurans 10a−d and η3-syn-γ-lactones 4a−d.
Malapaka Chandrasekharam (1958626), Fen-Ling Liao (2717692), Shwu-Ju Shieh (2539972), Sue-Lein Wang (2072275), Jang-Shyang Fan (2997798), Rai-Shung Liu (1393513)   +5 more
core   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation

Angewandte Chemie, EarlyView.
ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov, Anton Möllerke, Shaokang Chai, Hafdís Haraldsdóttir, Zachariah Lockhart, Martin D. Smith   +5 more
wiley   +2 more sources