Host lactosylceramide enhances Edwardsiella tarda infection
Cellular Microbiology, 2021 Edwardsiella tarda is a Gram-negative bacterium causing economic damage in aquaculture. The interaction of E. tarda with microdomains is an important step in the invasion, but the target molecules in microdomains remain undefined. Here, we found that intraperitoneal injection of E.
Kazuki Oishi +8 more
openaire +3 more sources
Biomolecules, 2020 An altered ceramide composition in patients with inflammatory bowel disease (IBD) has been reported recently. The aim of this study was to evaluate the concentrations of sphingolipids in the serum of treatment-naive children with newly diagnosed IBD and ...
Aleksandra Filimoniuk +4 more
doaj +2 more sources
Lactosylceramide induced by elastin-derived peptides decreases adipocyte differentiation [PDF]
Journal of Physiology and Biochemistry, 2020 Elastin, the major protein of the extracellular matrix, is specially found in cardiovascular tissues and contributing to 30-50% of the dry weight of blood vessels. Elastin regulates cell signalling pathways involved in morphogenesis, injury response and inflammation.
Thinhinane Hocine +10 more
openaire +4 more sources
α-Lactosylceramide Protects Against iNKT-Mediated Murine Airway Hyperreactivity and Liver Injury Through Competitive Inhibition of Cd1d Binding. [PDF]
Frontiers in Chemistry, 2019 Invariant natural killer T (iNKT) cells, which are activated by T cell receptor (TCR)-dependent recognition of lipid-based antigens presented by the CD1d molecule, have been shown to participate in the pathogenesis of many diseases, including asthma and ...
Chang, Ya-Jen +7 more
core +2 more sources
Frontiers in Neurology, 2019 We describe a 60-year-old woman with combined central and peripheral demyelination who presented with obstinate constipation, weakness in the lower limbs, and a bilateral sensory disturbance below her chest followed by girdle sensation in the right ...
Masaya Harada +10 more
doaj +2 more sources
Journal of Orthopaedic Translation, 2020 Background/Objective: Cyp24a1-null mice deficient in 24,25(OH)2D3 display impaired callus formation during the endochondral phase of bone fracture repair.
Corine Martineau +4 more
doaj +2 more sources
Lactosylceramide Interacts with and Activates Cytosolic Phospholipase A2α [PDF]
Journal of Biological Chemistry, 2013 Lactosylceramide (LacCer) is a member of the glycosphingolipid family and is known to be a bioactive lipid in various cell physiological processes. However, the direct targets of LacCer and cellular events mediated by LacCer are largely unknown. In this study, we examined the effect of LacCer on the release of arachidonic acid (AA) and the activity of ...
Hiroyuki, Nakamura +6 more
openaire +3 more sources
Properties and functions of lactosylceramide from mouse neutrophils [PDF]
Glycobiology, 2015 Lactosylceramide (LacCer), which is essential for many cellular processes, is highly expressed on the plasma membranes of human neutrophils and mediates innate immune functions. Less is known, however, about the properties and biological functions of LacCer in mouse neutrophils.
Kazuhisa, Iwabuchi +13 more
openaire +3 more sources
Association between arterial stiffness and serum L-octanoylcarnitine and lactosylceramide in overweight middle-aged subjects: 3-year follow-up study. [PDF]
PLoS ONE, 2015 Existing data on the association between being overweight and cardiovascular morbidity and mortality risk in adults are inconsistent. We prospectively and longitudinally investigated the effects of weight on arterial stiffness and plasma metabolites in ...
Minjoo Kim +3 more
doaj +2 more sources
A new assay for determining ganglioside sialyltransferase activities lactosylceramide-2,3-sialyltransferase (SAT I) and monosialylganglioside-2,3-sialyltransferase (SAT IV). [PDF]
PLoS ONE, 2014 A new assay for the determination of lactosylceramide-2,3-sialyltransferase (SAT I, EC 2.4.99.9) and monosialoganglioside sialyltransferase (SAT IV, EC 2.4.99.2) is described.
Cynthia Q Sun +4 more
doaj +2 more sources