Results 21 to 30 of about 7,301 (235)

Lactosylceramide-enriched Lipid Raft-mediated Infection Immunity

Medical Mycology Journal, 2018
More than 100 years have passed since Elie Metchnikoff discovered phagocytes. As molecular biological techniques have been developed and improved, we have gained deeper knowledge about the molecular mechanisms of immunological responses to invasion. The innate immune system is the inborn defense mechanism and the first line of defense against all kinds
K. Iwabuchi
openaire   +4 more sources

Involvement of murine β-1,4-galactosyltransferase V in lactosylceramide biosynthesis [PDF]

Glycoconjugate Journal, 2010
Human β-1,4-galactosyltransferase (β-1,4-GalT) V was shown to be involved in the biosynthesis of N-glycans, O-glycans and lactosylceramide (Lac-Cer) by in vitro studies. To determine its substrate specificity, enzymatic activity and its products were analyzed using mouse embryonic fibroblast (MEF) cells from β-1,4-GalT V (B4galt5)-mutant mice. Analysis
Tadahiro, Kumagai, Takeshi, Sato, Shunji, Natsuka, Yukito, Kobayashi, Dapeng, Zhou, Tadashi, Shinkai, Satoru, Hayakawa, Kiyoshi, Furukawa   +7 more
openaire   +3 more sources

Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes

International Journal of Molecular Sciences, 2021
Lactosylceramide (LacCer), also known as CD17/CDw17, is a member of a large family of small molecular weight compounds known as glycosphingolipids.
S. Chatterjee, Amrita Balram, Wendy Li
semanticscholar   +1 more source

Anti-Lactosylceramide antibody positive combined central peripheral demyelination emerging from long-standing juvenile-onset chronic inflammatory polyradiculoneuropathy; a report of two cases.

Journal of Neuroimmunology, 2023
Anti-Lactosylceramide (LacCer) antibodies are associated with neurological inflammation involving both the peripheral and central nervous system (PNS, CNS respectively), however, the documented number of cases is small.
N. Takegami, K. Sakuishi, Nanaka Yamaguchi-Takegami, Shuhei Egashira, Shogo Komaki, Tatsuro Mutoh, Tatsushi Toda   +6 more
semanticscholar   +1 more source

Convenient and Sensitive Measurement of Lactosylceramide Synthase Activity Using Deuterated Glucosylceramide and Mass Spectrometry

International Journal of Molecular Sciences, 2023
Lactosylceramide is necessary for the biosynthesis of almost all classes of glycosphingolipids and plays a relevant role in pathways involved in neuroinflammation.
M. Dei Cas, Linda Montavoci, S. Casati, N. Malagolini, F. dall’Olio, M. Trinchera   +5 more
semanticscholar   +1 more source

Qualitative and Quantitative Study of Glycosphingolipids in Human Milk and Bovine Milk Using High Performance Liquid Chromatography–Data-Dependent Acquisition–Mass Spectrometry

Molecules, 2020
Cerebrosides (Crb; including glucosylceramide and galactosylceramide) and lactosylceramide (LacCer) are structurally complex lipids found in many eukaryotic cell membranes, where they play important roles in cell growth, apoptosis, cell recognition and ...
Lin Ma, Bertram Y. Fong, Alastair K. H. MacGibbon, Gillian Norris   +3 more
doaj   +1 more source

Plasma Sphingolipid Profile Associated With Subclinical Atherosclerosis and Clinical Disease Markers of Systemic Lupus Erythematosus: Potential Predictive Value

Frontiers in Immunology, 2021
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects females more than males, with African Americans developing more severe manifestation of the disease.
Samar M. Hammad, Olivia C. Harden, Dulaney A. Wilson, Waleed O. Twal, Paul J. Nietert, Jim C. Oates, Jim C. Oates   +6 more
doaj   +1 more source

Serum sphingolipid profiling as a novel biomarker for metabolic syndrome characterization

Frontiers in Cardiovascular Medicine, 2022
BackgroundSphingolipids are components of cell membrane structure, but also circulate in serum and are essential mediators of many cellular functions. While ceramides have been proposed previously as a useful biomarker for cardiometabolic disease, the ...
Loni Berkowitz, Cristian Salazar, Carol D. Ryff, Christopher L. Coe, Attilio Rigotti   +4 more
doaj   +1 more source

Structure-functional activity relationship of β-glucans from the perspective of immunomodulation : a mini-review [PDF]

, 2020
β-Glucans are a heterogeneous group of glucose polymers with a common structure comprising a main chain of β-(1,3) and/or β-(1,4)-glucopyranosyl units, along with side chains with various branches and lengths.
Baruah, Sri Kartik, Bossier, Peter, Cox, Eric, Han, Biao, Vanrompay, Daisy   +4 more
core   +2 more sources

Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease.

Journal of Lipid Research, 1996
Polycystic kidney disease (PKD) is a common genetic disease characterized by the proliferation of epithelial cells, formation of cysts, and the progression of renal deficiency.
S Chatterjee, W Y Shi, P Wilson, A Mazumdar   +3 more
doaj   +1 more source