Glucosylceramide modulates membrane traffic along the endocytic pathway
Journal of Lipid Research, 2002 Glycosphingolipids are endocytosed and targeted to the Golgi apparatus, but are mistargeted to lysosomes in numerous sphingolipidoses. Substrate reduction therapy utilizes imino sugars to inhibit glucosylceramide synthase and potentially abrogate the ...
Dan J. Sillence +6 more
doaj +1 more source
The use of inhibitors to study endocytic pathways of gene carriers: optimization and pitfalls [PDF]
, 2010 Nonviral gene complexes can enter mammalian cells through different endocytic pathways. For efficient optimization of the gene carrier it is important to profile its cellular uptake, because this largely determines its intracellular processing and ...
Dries Vercauteren +57 more
core +3 more sources
The lactosylceramide binding specificity of Helicobacter pylori [PDF]
Glycobiology, 1998 The possible role of glycosphingolipids as adhesion receptors for the human gastric pathogen Helicobacter pylori was examined by use of radiolabeled bacteria, or protein extracts from the bacterial cell surface, in the thin-layer chromatogram binding assay.
J, Angström +11 more
openaire +2 more sources
Porcine intestinal glycosphingolipids recognized by F6-fimbriated enterotoxigenic Escherichia coli [PDF]
, 2014 One important virulence factor of enterotoxigenic Escherichia coli is their ability to adhere via fimbrial adhesins to specific receptors located on the intestinal mucosa. Here, the potential glycosphingolipid receptors of enterotoxigenic F6-fimbriated E.
Benktander, John +4 more
core +2 more sources
Journal of Lipid Research, 1995 The ceramide molecular species specificity of rat brain neuron CMP-N-acetylneuraminate:lactosylceramide alpha 2,3-sialyltransferase (LacCer alpha 2,3-ST) was determined using 19 molecular species of lactosylceramide incorporated into liposomes prepared ...
H. Kadowaki, M.A. Grant
doaj +1 more source
Beyond FimH: Diversity and Relevance of Carbohydrate-Binding Fimbrial Proteins in Escherichia coli. [PDF]
ChembiochemThis review discusses fimbrial lectins found in Escherichia coli (E. coli) other than FimH, which could be targeted to treat E. coli pathogenicity as an alternative to antibiotic treatment. Escherichia coli (E. coli) is responsible for multiple diseases in humans and animals.
Dulawa OR +3 more
europepmc +2 more sources
Human cytomegalovirus induces stage-specific embryonic antigen 1 in differentiating human teratocarcinoma cells and fibroblasts. [PDF]
, 1989 Cell surface expression of stage specific embryonic antigen 1 (SSEA-1), or Lex (III3 FucnLC4), was induced in differentiated human teratocarcinoma cells and in human diploid fibroblasts 3-6 d after infection with human cytomegalovirus (HCMV). In parallel,
Andrews, P.W. +6 more
core +1 more source
Sphingomyelin metabolism is involved in the differentiation of MDCK cells induced by environmental hypertonicity [PDF]
, 2015 Sphingolipids (SLs) are relevant lipid components of eukaryotic cells. Besides regulating various cellular processes, SLs provide the structural framework for plasma membrane organization.
Favale, Nicolas Octavio +4 more
core +1 more source
Involvement of very long fatty acid-containing lactosylceramide in lactosylceramide-mediated superoxide generation and migration in neutrophils [PDF]
Glycoconjugate Journal, 2007 The neutral glycosphingolipid lactosylceramide (LacCer) forms lipid rafts (membrane microdomains) coupled with the Src family kinase Lyn on the plasma membranes of human neutrophils; ligand binding to LacCer activates Lyn, resulting in neutrophil functions, such as superoxide generation and migration (Iwabuchi and Nagaoka, Lactosylceramide-enriched ...
K. Iwabuchi +13 more
openaire +3 more sources
The impact of chronic stress on the rat brain lipidome [PDF]
, 2016 Chronic stress is a major risk factor for several human disorders that affect modern societies. The brain is a key target of chronic stress. In fact, there is growing evidence indicating that exposure to stress affects learning and memory, decision ...
A Lamaziere +63 more
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