Results 71 to 80 of about 73,838 (343)

Pediatric dosing for locally acting drugs in submissions to the U.S. Food and Drug Administration between 2002 and 2020

Clinical and Translational Science, 2023
Deriving pediatric doses for locally acting drugs (LADs) presents a unique challenge because limited systemic exposure hinders commonly used approaches such as pharmacokinetic matching to adults.
Gelareh A. Abulwerdi, Anuradha Ramamoorthy, Edward Bashaw, Gilbert J. Burckart, Rajanikanth Madabushi, Elimika Pfuma Fletcher   +5 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

LADS

, 2014
Citation: 'LADS' in the IUPAC Compendium of Chemical Terminology, 3rd ed.; International Union of Pure and Applied Chemistry; 2006. Online version 3.0.1, 2019. 10.1351/goldbook.LT07408 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
openaire   +1 more source

BATSE Observations of Gamma-Ray Burst Spectra. IV. Time-Resolved High-Energy Spectroscopy [PDF]

, 1997
We report on the temporal behavior of the high-energy power law continuum component of gamma-ray burst spectra with data obtained by the Burst and Transient Source Experiment.
C. A. Meegan, Cavallo G., David L. Band, Geoffrey N. Pendleton, Hanlon L. O., James L. Matteson, Michael S. Briggs, Rees M. J., Robert D. Preece, Robert S. Mallozzi, William S. Paciesas   +10 more
core   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

tRNA modification enzyme MiaB connects environmental cues to activation of Pseudomonas aeruginosa type III secretion system.

PLoS Pathogens, 2022
Pseudomonas aeruginosa, a major inhabitant of numerous environmental reservoirs, is a momentous opportunistic human pathogen associated with severe infections even death in the patients suffering from immune deficiencies or metabolic diseases.
Qiqi Lin, Jiahui Huang, Zhiqing Liu, Qunyi Chen, Xinbo Wang, Guohui Yu, Ping Cheng, Lian-Hui Zhang, Zeling Xu   +8 more
doaj   +1 more source

The Bradford & Airedale Health of Men initiative: a study of its effectiveness in engaging with men [PDF]

, 2008
The Health of Men (HoM) network received funding from the Big Lottery Fund in 2003 to establish a five year programme of dedicated work with men and boys.
Branney, P, Cash, K, Conrad, D, White, AK   +3 more
core  

Free Energy of a Heavy Quark-Antiquark Pair in a Thermal Medium from AdS/CFT

, 2018
We study the free energy of a heavy quark-antiquark pair in a thermal medium using the AdS/CFT correspondence. We point out that a commonly used prescription for calculating this quantity leads to a temperature dependence in conflict with general ...
Ewerz, Carlo, Kaczmarek, Olaf, Samberg, Andreas   +2 more
core   +1 more source

String Theory on AdS_3 [PDF]

, 1998
It was shown by Brown and Henneaux that the classical theory of gravity on AdS_3 has an infinite-dimensional symmetry group forming a Virasoro algebra. More recently, Giveon, Kutasov and Seiberg (GKS) constructed the corresponding Virasoro generators in ...
de Boer, Jan, Ooguri, Hirosi, Robins, Harlan, Tannenhauser, Jonathan   +3 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source