Results 71 to 80 of about 7,574 (306)

Lads mags, young men’s attitudes towards women and acceptance of myths about sexual aggression. [PDF]

, 2011
This commentary is a precursor to a forthcoming study exploring young men’s consumption of ‘lads’ mags’ – lifestyle magazines aimed at young men that feature young women in sexualized poses – specifically, their implications for men’s attitudes towards ...
Horvath, M., Coy, M.
core   +1 more source

Pediatric dosing for locally acting drugs in submissions to the U.S. Food and Drug Administration between 2002 and 2020

Clinical and Translational Science, 2023
Deriving pediatric doses for locally acting drugs (LADs) presents a unique challenge because limited systemic exposure hinders commonly used approaches such as pharmacokinetic matching to adults.
Gelareh A. Abulwerdi, Anuradha Ramamoorthy, Edward Bashaw, Gilbert J. Burckart, Rajanikanth Madabushi, Elimika Pfuma Fletcher   +5 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Clinical, Pathological, and Molecular Features of Lung Adenocarcinomas with AXL Expression. [PDF]

PLoS ONE, 2016
The receptor tyrosine kinase AXL is a member of the Tyro3-Axl-Mer receptor tyrosine kinase subfamily. AXL affects several cellular functions, including growth and migration.
Katsuaki Sato, Kenichi Suda, Shigeki Shimizu, Kazuko Sakai, Hiroshi Mizuuchi, Kenji Tomizawa, Toshiki Takemoto, Kazuto Nishio, Tetsuya Mitsudomi   +8 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

LADS Survey - A Case Study on Australia's Northwest Shelf [PDF]

, 2002
Laser Airborne Depth Sounder (LADS) systems provide an accurate, rapid and cost effective method of surveying coastal areas. These systems have been used by governments and commercial organisations over the last decade to conduct surveys for nautical ...
Sinclair, Mark
core   +1 more source

Intangible Cultural Heritage of the Făgăraș Land. Priority Dimensions

Bulletin of the Transilvania University of Braşov: Series VII: Social Sciences, Law, 2020
Between March 2018 and February 2019, an interdisciplinary team from Transylvania University of Brasov developed a project to create an inventory of intangible cultural heritage resources in the Făgăraș Land.
D. Sorea, C. Csesznek
doaj   +1 more source

From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care

Molecular Oncology, EarlyView.
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard, Flavie Bénard, Eva Billat, Margaux Le Guyon, Victoria Maltret, Laura Merlet, Chloé Astrid Walter, Tony Avril, Eric Chevet   +8 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Engineering of an Hepatic Organoid to Develop Liver Assist Devices

Cell Transplantation, 2010
Cell-based technologies to support/restore liver function represent one of the most promising opportunities in the treatment of acute liver failure.
Alejandro Soto-Gutierrez M.D., Ph.D., Nalú Navarro-Alvarez, Hiroshi Yagi, Yakoov Nahmias, Martin L. Yarmush, Naoya Kobayashi   +5 more
doaj   +1 more source