Results 91 to 100 of about 88,672,115 (295)
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
What role can LAG-3-blocking antibodies play in melanoma therapy?
, 2023 What role can LAG-3-blocking antibodies play in melanoma ...
Paulina Jagodzińska-Mucha (17372879) +1 more
core +1 more source
Targeting LAG-3+ T cells for cancer immunotherapy [PDF]
Lymphocyte activation gene 3 (LAG-3) is a promising co-inhibitory receptor target which has been shown to negatively regulate T cell responses. However, the minutiae of LAG-3 biology are poorly understood and its role as a prognostic factor in different ...
Capitani, Lorenzo
core +4 more sources
Lymphocyte Activation Gene-3 Maintains Mitochondrial and Metabolic Quiescence in Naive CD4+ T Cells
Cell Reports, 2019 Summary: Lymphocyte activation gene-3 (LAG-3) is an inhibitory receptor expressed by CD4+ T cells and tempers their homeostatic expansion. Because CD4+ T cell proliferation is tightly coupled to bioenergetics, we investigate the role of LAG-3 in ...
Dana M. Previte +10 more
doaj +1 more source
GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma
FEBS Open Bio, EarlyView.GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain +11 more
wiley +1 more source
Lag-3−/− Tcon accelerates GVHD.
, 2014 Lethally irradiated Balb/c recipients were transplanted with 5×106 TCD-BM and various doses of Tcon from either Lag-3−/− or WT C57Bl/6 mice and monitored for survival (A–C) and GVHD score (D–E).
Dennis B. Leveson-Gower (515309) +5 more
core +1 more source
FEBS Open Bio, EarlyView.In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey +4 more
wiley +1 more source
These datasets are linked to cancer immunotherapy research. Current immunotherapies often fail because they generate inadequate T-cell responses or cause immune-related adverse events (irAE), a problem that can be exacerbated by combination treatments ...
Awen Gallimore (19077164) +1 more
core +1 more source
Frontiers in OncologyLymphocyte activation gene 3 (LAG-3), also known as CD223, is an emerging immune checkpoint that follows PD-1 and CTLA-4. Several LAG-3 targeting inhibitors in clinical trials and the combination of relatlimab (anti-LAG-3) and nivolumab (anti-PD-1) have ...
Yingzhe Luo +5 more
doaj +1 more source
Journal of Orthopaedic Surgery and Research, 2019 Background Intramedullary hip nails may be classified as blades or screws depending on the type of lag screw used. Recently, a combination of lag screw types with a U-clip insertion has also been used.
Jehyun Yoo +3 more
doaj +1 more source