Results 41 to 50 of about 17,219,459 (310)
Frontiers in Oncology, 2023 IntroductionImmune checkpoint inhibitor (ICI) is one of the standard treatment strategies in triple negative breast cancer (TNBC). However, the benefit of ICI with chemotherapy is limited in metastatic TNBC.
Ji-Yeon Kim +12 more
doaj +1 more source
Potential for using climate forecasts in spatio-temporal prediction of dengue fever incidence in Malaysia submitted [PDF]
, 2015 Dengue fever is a viral infection transmitted by the bite of female Aedes aegypti mosquitoes. It is estimated that nearly 40% of the world’s population is now at risk from Dengue in over 100 endemic countries including Malaysia.
Harun, Amran +2 more
core +3 more sources
Fibrinogen-like Protein 1 Is a Major Immune Inhibitory Ligand of LAG-3
Cell, 2019 Lymphocyte-activation gene 3 (LAG-3) is an immune inhibitory receptor, with major histocompatibility complex class II (MHC-II) as a canonical ligand. However, it remains controversial whether MHC-II is solely responsible for the inhibitory function of ...
Jun Wang +20 more
semanticscholar +1 more source
Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3).
ACS Medicinal Chemistry Letters, 2023 Lymphocyte activation gene 3 (LAG-3) is a negative immune checkpoint that plays a key role in downregulating the immune response to cancer. Inhibition of LAG-3 interactions allows T cells to regain cytotoxic activity and reduce the immunosuppressive ...
Somaya A. Abdel-Rahman +2 more
semanticscholar +1 more source
Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity. [PDF]
PLoS ONE, 2014 Environmental factors including drugs, mineral oils and heavy metals such as lead, gold and mercury are triggers of autoimmune diseases in animal models or even in occupationally exposed humans.
Vibha Jha +6 more
doaj +1 more source
Polyfunctional Melan-A-specific tumor-reactive CD8+ T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS [PDF]
, 2016 The identification of activation pathways linked to anti-tumor T-cell polyfunctionality in long surviving patients is of great relevance in the new era of immunotherapy.
Belinda, Palermobc +7 more
core +1 more source
Frontiers in Immunology, 2023 Introduction Immune checkpoint blockade (ICB) is a systemic therapeutic option for advanced hepatocellular carcinoma (HCC). However, low patient response rates necessitate the development of robust predictive biomarkers that identify individuals who will
Chun Chau Lawrence Cheung +18 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Background The diffuse large B-cell lymphoma (DLBCL) has the highest incidence of all lymphomas worldwide. To investigate the functions of lymphocyte activation gene 3 (LAG-3) and programmed cell death 1 (PD-1) in tissues and peripheral blood of patients
Jiajia Ma +5 more
semanticscholar +1 more source
OncoImmunology, 2019 Suppression of immune reactivity by increased expression of co-inhibitory receptors has been discussed as a major reason as to why the immune system fails to control tumor development.
Emelie Rådestad +6 more
doaj +1 more source
Biomolecules, 2019 Immune checkpoint inhibition (ICI) is a promising cancer therapy, which has progressed rapidly from a preclinical concept to clinical implementation. Commonly considered targets in ICI are CTLA-4, PD-1/PD-L1, and LAG-3, and the list grows.
Quentin Lecocq +9 more
doaj +1 more source