Results 31 to 40 of about 88,672,115 (295)
Lymphocyte Activation Gene-3 (LAG-3) negatively regulates environmentally-induced autoimmunity. [PDF]
PLoS ONE, 2014 Environmental factors including drugs, mineral oils and heavy metals such as lead, gold and mercury are triggers of autoimmune diseases in animal models or even in occupationally exposed humans.
Vibha Jha +6 more
doaj +1 more source
, 2017 Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens.
Joller, Nicole, Kuchroo, Vijay K.
openaire +4 more sources
OncoImmunology, 2019 Suppression of immune reactivity by increased expression of co-inhibitory receptors has been discussed as a major reason as to why the immune system fails to control tumor development.
Emelie Rådestad +6 more
doaj +1 more source
Biomolecules, 2019 Immune checkpoint inhibition (ICI) is a promising cancer therapy, which has progressed rapidly from a preclinical concept to clinical implementation. Commonly considered targets in ICI are CTLA-4, PD-1/PD-L1, and LAG-3, and the list grows.
Quentin Lecocq +9 more
doaj +1 more source
International Journal of Immunopathology and Pharmacology, 2022 Objectives Lymphocyte-activation gene 3 (LAG-3) represents a potential immune checkpoint target for cancer treatment. We investigated LAG-3 expression and its prognostic value in patients with surgically treated clear cell renal cell carcinoma (RCC) and ...
Chan Ho Lee +7 more
doaj +1 more source
Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3)
, 2023 Lymphocyte activation gene 3 (LAG-3) is a negative immune checkpoint that plays a key role in downregulating the immune response to cancer. Inhibition of LAG-3 interactions allows T cells to regain cytotoxic activity and reduce the immunosuppressive ...
Somaya A. Abdel-Rahman (9362683) +2 more
core +2 more sources
LAG-3: from molecular functions to clinical applications
Journal for ImmunoTherapy of Cancer, 2020 To prevent the destruction of tissues owing to excessive and/or inappropriate immune responses, immune cells are under strict check by various regulatory mechanisms at multiple points.
Takumi Maruhashi +3 more
doaj +1 more source
Role of LAG-3 in Regulatory T Cells [PDF]
Immunity, 2004 Regulatory T cells (Tregs) limit autoimmunity but also attenuate the magnitude of antipathogen and antitumor immunity. Understanding the mechanism of Treg function and therapeutic manipulation of Tregs in vivo requires identification of Treg-selective receptors.
Huang, Ching-Tai +13 more
openaire +2 more sources
Programmed cell death protein-1 and other inhibitory receptors expressed by regulatory T cells as a restraining factor of checkpoint therapy [PDF]
Archive of OncologyThe effectiveness of anti-PD-1/PD-L1 targeted therapies focused on the antitumor immune response restoration in the treatment of melanoma and several other tumors has renewed trust in immunotherapy potential. Despite inspiring enthusiasm that led both to
Batorov Egor V. +2 more
doaj +1 more source
Histopathological Evaluation of LAG-3, TIM-3 AND CD38 Levels in Meningiomas
Cam & Sakura Medical Journal, 2021 Objective: Meningiomas are the most common primary intracranial tumors in adults that account for 36% of primary tumors. Treatment options other than surgery and radiotherapy are necessary for meningioma.
Uzay Erdoğan +5 more
doaj +1 more source