Results 81 to 90 of about 17,219,459 (310)

Generalised additive model of DIR based on region, monsoon and state in Peninsular Malaysia [PDF]

, 2019
A generalised additive model (GAM) framework for dengue incidence rate (DIR) as a response in Peninsular Malaysia for three areas which as region, monsoon and state has been adopted in this study.
Che Him, Norziha, Samat, Nor Azah, Yusof, Yusliandy   +2 more
core  

Relatlimab: a novel drug targeting immune checkpoint LAG-3 in melanoma therapy

Frontiers in Pharmacology
Relatlimab is a type of human immunoglobulin G4 monoclonal blocking antibody. It is the world’s first Lymphocyte-Activation Gene-3 (LAG-3) inhibitor and the third immune checkpoint inhibitor with clinical application, following PD-1 and CTLA-4 ...
Jingjing Su, Yiting Fu, Zitong Cui, Zain Abidin, Jingsong Yuan, Xinmiao Zhang, Runmin Li, Chunzhen Zhao   +7 more
semanticscholar   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Lymphocyte activation gene 3 is increased and affects cytokine production in rheumatoid arthritis

Arthritis Research & Therapy, 2023
Background Lymphocyte activation gene-3 (LAG-3) inhibits T cell activation and interferes with the immune response by binding to MHC-II. As antigen presentation is central in rheumatoid arthritis (RA) pathogenesis, we studied aspects of LAG-3 as a ...
Janni Maria Pedersen, Aida Solhøj Hansen, Cæcilie Skejø, Kristian Juul-Madsen, Peter Junker, Kim Hørslev-Petersen, Merete Lund Hetland, Kristian Stengaard-Pedersen, Mikkel Østergaard, Bjarne Kuno Møller, Lene Dreyer, Ellen-Margrethe Hauge, Malene Hvid, Stinne Greisen, Bent Deleuran   +14 more
doaj   +1 more source

On the role of the inhibitory receptor LAG-3 in acute and chronic LCMV infection [PDF]

, 2017
Chronic viral infections are often characterized by CD8 T-cell responses with poor cytokine secretion potential and limited expansion of the CD8 T-cell pool, collectively referred to as CD8 T-cell exhaustion.
Agnellini, Paola, Oxenius, Annette, Richter, Kirsten   +2 more
core  

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

High co-expression of immune checkpoint receptors PD-1, CTLA-4, LAG-3, TIM-3, and TIGIT on tumor-infiltrating lymphocytes in early-stage breast cancer

World Journal of Surgical Oncology, 2022
High expression of immune checkpoint receptors (ICRs) in the tumor microenvironment regulates the anti-tumor response. In this study, the differential expressions of ICRs on tumor-infiltrating lymphocytes (TILs) in patients with early-stage breast cancer
Baran Mollavelioğlu, Esin Çetin Aktaş, N. Cabıoğlu, A. Abbasov, S. Onder, S. Emiroğlu, M. Tükenmez, M. Muslumanoglu, A. Iğci, G. Deniz, V. Ozmen   +10 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Lymphocyte activating gene 3 protein expression in nasopharyngeal carcinoma is correlated with programmed cell death-1 and programmed cell death ligand-1, tumor-infiltrating lymphocytes

Cancer Cell International, 2021
Background Immunotherapy has shown promising efficacy in patients with nasopharyngeal carcinoma (NPC). Lymphocyte activating 3 gene (LAG-3) represents a significant immune target, however, its relationship with NPC remains unclear.
Fan Luo, Jiaxin Cao, Feiteng Lu, Kangmei Zeng, Wenjuan Ma, Yan Huang, Li Zhang, Hongyun Zhao   +7 more
doaj   +1 more source

ANALISIS KAUSALITAS ANTARA PDRB DAN TINGKAT EMPLOYMENT DI JAWA TIMUR TAHUN 1979 – 2004 [PDF]

, 2006
Dalam penelitian ini penulis mengambil judul “ ANALISIS KAUSALITAS PDRB DAN TINGKAT EMPLOYMENT DI JAWA TIMUR TAHUN 1979-2004 ”. Penelitian ini merupakan penelitian yang bersifat deskriptif kuantitatif dengan menggunakan data urut waktu (time series)
WIJAYANTI , DINUNG TRI
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