Results 1 to 10 of about 52,713 (325)
Lamin C is required to establish genome organization after mitosis
Genome Biology, 2021 Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong +5 more
doaj +2 more sources
Heart, 2017 Lamins A and C are intermediate filament nuclear envelope proteins encoded by theLMNAgene. Mutations inLMNAcause autosomal dominant severe heart disease, accounting for 10% of dilated cardiomyopathy (DCM). Characterised by progressive conduction system disease, arrhythmia and systolic impairment, lamin A/C heart disease is more malignant than other ...
G. Captur +13 more
semanticscholar +6 more sources
Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes [PDF]
Nature CommunicationsBarrier-to-autointegration factor (BAF) associates with mitotic chromosomes and promotes nuclear envelope assembly by recruiting proteins, such as Lamins, required for the reconstruction of the nuclear envelope and lamina.
Naoki Horikoshi +5 more
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Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease
EMBO Molecular Medicine, 2020 Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder.
Rafael Alcalá‐Vida +14 more
doaj +2 more sources
Lamins regulate cancer cell plasticity and chemosensitivity [PDF]
Frontiers in OncologyBackgroundStem cell plasticity plays key roles in mammalian organogenesis, tissue homeostasis, and carcinogenesis. Given its tolerance to anti-tumor therapy and its promotion on immunosuppressive microenvironment, cancer cell plasticity is a major ...
Guofang Chen +8 more
doaj +2 more sources
High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis [PDF]
Respiratory ResearchBackground Cellular senescence is one of the key steps in the progression of pulmonary fibrosis, and the senescence of type II alveolar epithelial cells (AEC IIs) may potentially accelerate the progression of pulmonary fibrosis.
Junhui Ba +9 more
doaj +2 more sources
Journal of Experimental & Clinical Cancer Research, 2019 Background Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components.
Yunong Li +9 more
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The wide and growing range of lamin B-related diseases: from laminopathies to cancer
Cellular and Molecular Life Sciences, 2022 B-type lamins are fundamental components of the nuclear lamina, a complex structure that acts as a scaffold for organization and function of the nucleus.
C. Evangelisti +7 more
semanticscholar +1 more source
Frontiers in Bioscience-Landmark, 2023 Background: Lamins are the major component of nuclear lamina. Alternative splicing of the 12 exons comprising lamin A/C gene creates five known transcript variants, lamin A, lamin C, lamin AΔ10, lamin AΔ50, and lamin C2. The main objective for this study
Lin Batha +6 more
doaj +1 more source
LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior
eLife, 2021 Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar +8 more
doaj +1 more source