Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation
bioRxiv, 2019 The nucleus is the largest organelle and information center of the cell; while we identify the diverse components of the cells as mechanotransduction elements, the deformation of the nucleus itself is emerging as a critical mechanosensory structure ...
Luv Kishore Srivastava +3 more
semanticscholar +1 more source
Lamin B1 mapping reveals the existence of dynamic and functional euchromatin lamin B1 domains
Nature Communications, 2018 Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a yet unknown function.
Laura Pascual-Reguant +13 more
semanticscholar +1 more source
Anti-lamin A/C antibodies in patients with Behçet’s disease
Central European Journal of Immunology, 2018 Lamin A/C has been identified as a target antigen of anti-endothelial cell antibodies in vasculitis. Behçet’s disease (BD) is a chronic vasculitis with unclear pathogenesis.
Peng Chen +4 more
doaj +1 more source
Partially Hyperbolic Sets with a Dynamically Minimal Invariant Lamination [PDF]
arXiv, 2017 We study partially hyperbolic sets of C1-diffeomorphisms. For these sets there are defined the strong stable and strong unstable laminations. A lamination is called dynamically minimal when the orbit of each leaf intersects the set densely. We prove that partially hyperbolic sets having a dynamically minimal lamination have empty interior.
arxiv
Nucleic Acids Research, 2018 Lamins are the main components of the nucleoskeleton. Whereas their 3D organization was recently described using cryoelectron tomography, no structural data highlights how they interact with their partners at the interface between the inner nuclear ...
C. Samson +10 more
semanticscholar +1 more source
A Seifert algorithm for lamination links [PDF]
arXiv, 2017 We generalize H. Seifert's algorithm for finding a Seifert surface for a knot or link. The generalization applies to "framed oriented measured lamination links." For knots, a Seifert surface determines a unique framing. In our setting, we analyze the set of framed lamination links which bound Seifert laminations and are carried by an $S^1$-fibered tube
arxiv
p53 induces senescence through Lamin A/C stabilization-mediated nuclear deformation
Cell Death and Disease, 2019 p53-mediated cellular senescence has been intensively investigated, because it is important for tumor suppressive function. In addition, p16/INK4A is well known to be critical for cellular senescence.
Min-Ho Yoon +7 more
semanticscholar +1 more source
Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades
eLife, 2016 Intermediate filament (IF) proteins, including nuclear lamins and cytoplasmic IF proteins, are essential cytoskeletal components of bilaterian cells. Despite their important role in protecting tissues against mechanical force, no cytoplasmic IF proteins ...
Lars Hering +4 more
doaj +1 more source
Laminations with transverse measures in ordered abelian semigroups [PDF]
arXiv, 2014 We describe a construction of ordered algebraic structures (ordered abelian semigroups, ordered commutative semirings, etc.) and describe applications to codimension-1 laminations. For a suitable ordered semi- algebraic structure $\mathbb L$ and measurable space $X$ we define $\mathbb L$-measures $\nu$ on $X$.
arxiv
Brain protein kinase C phosphorylating poly(arginine,serine) or lamin B is stimulated by anions and by an activator purified from bovine serum albumin preparations. [PDF]
, 1989 M Abdel-Ghany +4 more
openalex +1 more source