Results 121 to 130 of about 92,845 (317)

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle. [PDF]

, 2019
Migration through 3D constrictions can cause nuclear rupture and mislocalization of nuclear proteins, but damage to DNA remains uncertain, as does any effect on cell cycle.
Bannister, Beadle, Belin, Bennett, Britton, Buxboim, Charlotte R. Pfeifer, Cho, Cornelius, Cumming, Dazhen Liu, Denais, Dennis E. Discher, Dong, Duheron, Emily J. Chen, Frigault, Garay, Giese, Gomes, Grundy, Harada, Harding, Hatch, Houtgraaf, Imlay, Irena L. Ivanovska, Irianto, Irianto, Ivkovic, Jerome Irianto, Kalia Pannell, Khatau, Kryston, Kuangzheng Zhu, Lawrence J. Dooling, Lee, Liu, Liu, Lu, Lucas R. Smith, López-Bigas, Maciejowski, Mahaseth, Mai Wang, Mavrakis, Mello Filho, Michael P. Tobin, Mogilner, Morita, Pajerowski, Pathak, Petrie, Pfeifer, Pfeifer, Raab, Raab, Radisky, Rancati, Rice, Rico, Rizvi, Roger A. Greenberg, Sancar, Skamagki, Strano, Stroka, Surcel, Takaki, Thiam, Thomas, Turgay, Wang, Wolf, Xia, Yan, Yuntao Xia, Zhang   +77 more
core   +1 more source

Liver Stiffness Rises Early in MASLD and Drives Inflammation, Lipid Dysmetabolism, and Fibrosis via Piezo1–YAP Mechanotransduction

Advanced Science, EarlyView.
Progressive stiffening of the hepatic extracellular matrix and free fatty acid overload activate the mechanosensor Piezo1 in steatotic hepatocytes, inducing calcium influx and nuclear translocation of Yes‐associated protein. YAP‐dependent nuclear signaling further drives inflammatory and fibrotic gene programs, lipid metabolic reprogramming, and ...
Juan Ma, Ning Xie, Ziwei Wang, Xiru Liang, Yulong Han, Qiang Zhao, Ming Wang, Hongwei Lu, Wanyi Kou, William Alazawi, Jinhai Wang, Lu Li, Ning Liu, Na Liu, Haitao Shi, Feng Xu   +15 more
wiley   +1 more source

Novel PMVs/ZIP4/Zinc/Prelamin A Axis Promotes Nuclear Dysmorphism and Vascular Aging in Humans and Rodents Post-Injury: Effective Treatment With Platelet Membrane-Coated ZIF-8 Nanoparticles. [PDF]

Aging Cell
Interventional therapy and surgical injury induce nuclear dysmorphism and vascular aging. Nuclear dysmorphism is positively associated with vascular aging. Novel PMVs/ZIP4/Zinc/preLamin A axis plays a key role in injury‐induced nuclear dysmorphism and vascular aging.
Ma T, Bao H, Xu Z, Ren H, Tian W, Chen J, Liu Z, Lu X, Lv F, Yao Q, Qi Y, Huang K.   +11 more
europepmc   +2 more sources

Lamin A/C and Emerin depletion impacts chromatin organization and dynamics in the interphase nucleus

BMC Molecular and Cell Biology, 2019
Nuclear lamins are type V intermediate filament proteins that maintain nuclear structure and function. Furthermore, Emerin - an interactor of Lamin A/C, facilitates crosstalk between the cytoskeleton and the nucleus as it also interacts with actin and ...
Devika Ranade, Roopali Pradhan, Muhunden Jayakrishnan, Sushmitha Hegde, Kundan Sengupta   +4 more
semanticscholar   +1 more source

NIBAN2/FLII/RREB1 Axis Drives Glioma Stem Cell Malignancy via TLR3 Pathway Activation

Advanced Science, EarlyView.
NIBAN2, highly expressed in glioma stem‐like cells (GSCs), assembles with FLII and transcription factor RREB1 to form a nuclear complex. This complex transcriptionally activates stemness‐associated genes (e.g., CD44, NANOG) and metabolic enzymes (e.g., LDHA), thereby sustaining both transcriptional and metabolic stemness programs.
Liang liang Shi, Xinwei Qiao, Yue Hu, Minjie Wang, Shaojie Yu, Zihan Gong, Yuxin Rao, Hui Zheng, Siting Chen, Lin Li, Rong Fu, Tao Liang, Jin Yao, Xiaobing Jiang, Junjun Li   +14 more
wiley   +1 more source

Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation

bioRxiv, 2019
The nucleus is the largest organelle and information center of the cell; while we identify the diverse components of the cells as mechanotransduction elements, the deformation of the nucleus itself is emerging as a critical mechanosensory structure ...
Luv Kishore Srivastava, Z. Ju, Ajinkya Ghagre, A. Ehrlicher   +3 more
semanticscholar   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, EarlyView.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin [PDF]

, 1998
A number of structural and functional subnuclear compartments have been described, including regions exclusive of chromosomes previously hypothesized to form a reactive nuclear space.
Bridger, JM, Herrmann, H, Lichter, P, Muenkel, C   +3 more
core  

Genomic instability and DNA replication defects in progeroid syndromes [PDF]

, 2018
Progeroid syndromes induced by mutations in lamin A or in its interactors – named progeroid laminopathies – are model systems for the dissection of the molecular pathways causing physio- logical and premature aging.
Chiara Merigliano, Fiammetta Vernì, Isabella Saggio, Mattia La Torre, Romina Burla   +4 more
core   +1 more source

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source