Results 151 to 160 of about 52,713 (325)
Environmental Toxicology, EarlyView.ABSTRACT We examined the antioxidant and anti‐inflammatory effects of the methanolic extract of Dendranthema oreastrum (Hance) Y.Ling, commonly known as “Gu‐Jeol‐Cho” in Korea and widely found across East Asia, using an LPS‐induced acute lung injury (ALI) mouse model and TNF‐α‐stimulated NCI‐H292 cells.
Ji‐Hye Ha +11 more
wiley +1 more source
CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy
VIEW, EarlyView.Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma +6 more
wiley +1 more source
British Journal of Management, EarlyView.Abstract Ethnic issues have been creating complex sociopolitical realities and grand challenges for economic activities in many countries, yet much less is known about their micro‐level effects on international business. This study explores the impact of ethnic polarization in target countries on equity ownership in cross‐border acquisitions (CBAs) by ...
Jianhong Zhang, Jiangang Jiang
wiley +1 more source
A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro. [PDF]
, 1991 G. Dessev +4 more
openalex +1 more source
Nuclear Import Defects Drive Cell Cycle Dysregulation in Neurodegeneration
Aging Cell, EarlyView.Overview of Dysregulated Cell Cycle Mechanisms in Neuronal Cells. A nuclear import block drives cell cycle re‐entry from G0, culminating in cell cycle arrest at G1/S. This cell cycle arrest is associated with activation of CKIs from the INK locus (p15, p16, p18, p19) and Cip/Kip (p21, p27) which act on specific CDK/Cyclin complexes.
Jonathan Plessis‐Belair +3 more
wiley +1 more source
Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34cdc2 [PDF]
, 1992 Marcus E. Peter +3 more
openalex +1 more source
DLK/JNK3 Upregulation Aggravates Hair Cell Senescence in Mice Cochleae via Excessive Autophagy
Aging Cell, EarlyView.In normal physiological processes, autophagy acts as a protective factor against aging stress. With the stress increase, the DLK/JNK3 pathway is activated and autophagy is continuously upregulated. In our study, excessive autophagy leads to hair cell senescence, which reveals that excessive autophagy can play a harmful role in senescence under certain ...
Rui Ding +8 more
wiley +1 more source
hTERT Increases TRF2 to Induce Telomere Compaction and Extend Cell Replicative Lifespan
Aging Cell, EarlyView.In contrast to the dogma that a subset of short telomeres initiates senescence, hTERT variants unable to maintain telomere length block senescence by stabilizing TRF2 via inhibiting upstream E3 ubiquitin ligases. This noncanonical hTERT function also compacts telomeres and blocks senescence‐associated DNA damage signaling. Cancer cells expressing hTERT
Nancy Adam +15 more
wiley +1 more source
Aging Cell, EarlyView.Here, we reanalyze single‐cell RNA sequencing datasets demonstrating hippocampal adult neural stem cell (NSC) heterogeneity to resolve classification inconsistencies and identify conserved gene markers. Our findings enhance understanding of NSC dynamics, aging, and senescence, providing a framework for standardized classification and improved insights ...
Oliver Polzer +4 more
wiley +1 more source