Results 11 to 20 of about 53,083 (269)

Lamin C is required to establish genome organization after mitosis

Genome Biology, 2021
Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong, Victoria E. Hoskins, Ashley J. Melendez-Perez, Jennifer C. Harr, Molly Gordon, Karen L. Reddy   +5 more
doaj   +2 more sources

Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes [PDF]

Nature Communications
Barrier-to-autointegration factor (BAF) associates with mitotic chromosomes and promotes nuclear envelope assembly by recruiting proteins, such as Lamins, required for the reconstruction of the nuclear envelope and lamina.
Naoki Horikoshi, Ryosuke Miyake, Chizuru Sogawa-Fujiwara, Mitsuo Ogasawara, Yoshimasa Takizawa, Hitoshi Kurumizaka   +5 more
doaj   +2 more sources

High matrix stiffness promotes senescence of type II alveolar epithelial cells by lysosomal degradation of lamin A/C in pulmonary fibrosis [PDF]

Respiratory Research
Background Cellular senescence is one of the key steps in the progression of pulmonary fibrosis, and the senescence of type II alveolar epithelial cells (AEC IIs) may potentially accelerate the progression of pulmonary fibrosis.
Junhui Ba, Changyu Zheng, Yimei Lai, Xin He, Yuxi Pan, Yanqiu Zhao, Huihui Xie, Benquan Wu, Xiao Deng, Nan Wang   +9 more
doaj   +2 more sources

Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

EMBO Molecular Medicine, 2020
Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder.
Rafael Alcalá‐Vida, Marta Garcia‐Forn, Carla Castany‐Pladevall, Jordi Creus‐Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí‐Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez‐Navarro   +14 more
doaj   +2 more sources

Differential Gene Expression Signatures and Cellular Signaling Pathways induced by Lamin A/C Transcript Variants in MCF7 Cell Line

Frontiers in Bioscience-Landmark, 2023
Background: Lamins are the major component of nuclear lamina. Alternative splicing of the 12 exons comprising lamin A/C gene creates five known transcript variants, lamin A, lamin C, lamin AΔ10, lamin AΔ50, and lamin C2. The main objective for this study
Lin Batha, Mohammad Azhar Aziz, Mahmoud Zhra, Jasmine Holail, Wedad S. Al-Qahtani, Rajaa Fakhoury, Ahmad Aljada   +6 more
doaj   +1 more source

The wide and growing range of lamin B-related diseases: from laminopathies to cancer

Cellular and Molecular Life Sciences, 2022
B-type lamins are fundamental components of the nuclear lamina, a complex structure that acts as a scaffold for organization and function of the nucleus.
C. Evangelisti, Isabella Rusciano, S. Mongiorgi, G. Ramazzotti, G. Lattanzi, L. Manzoli, L. Cocco, Stefano Ratti   +7 more
semanticscholar   +1 more source

LAP2alpha maintains a mobile and low assembly state of A-type lamins in the nuclear interior

eLife, 2021
Lamins form stable filaments at the nuclear periphery in metazoans. Unlike B-type lamins, lamins A and C localize also in the nuclear interior, where they interact with lamin-associated polypeptide 2 alpha (LAP2α).
Nana Naetar, Konstantina Georgiou, Christian Knapp, Irena Bronshtein, Elisabeth Zier, Petra Fichtinger, Thomas Dechat, Yuval Garini, Roland Foisner   +8 more
doaj   +1 more source

Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway

Nucleic Acids Research, 2022
Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies.
S. Maynard, Arnaldur Hall, P. Galanos, S. Rizza, Tatsuro Yamamoto, Helena Hagner Gram, S. Munk, Muhammad Shoaib, C. Sørensen, V. Bohr, Mads Lerdrup, A. Maya-Mendoza, J. Bartek   +12 more
semanticscholar   +1 more source

Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS

bioRxiv, 2022
In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to maintain nuclear structure. The nuclear lamins, the major structural components of the NL, are involved in the protection against NE rupture induced by mechanical ...
Yohei Kono, S. Adam, K. Reddy, Yixian Zheng, O. Medalia, R. Goldman, H. Kimura, T. Shimi   +7 more
semanticscholar   +1 more source

Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

bioRxiv, 2021
The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age-related pathologies. Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes ...
Isadora Matias, L. P. Diniz, I. Damico, Laís da Silva Neves, Ana Paula Bergamo Araujo, Gabriele Vargas, R. Leite, C. Suemoto, R. Nitrini, W. Jacob-Filho, L. Grinberg, E. Hol, J. Middeldorp, Flávia Carvalho Alcantara Gomes   +13 more
semanticscholar   +1 more source