Results 11 to 20 of about 96,178 (343)

Lamin C is required to establish genome organization after mitosis

Genome Biology, 2021
Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong, Victoria E. Hoskins, Ashley J. Melendez-Perez, Jennifer C. Harr, Molly Gordon, Karen L. Reddy   +5 more
doaj   +2 more sources

Low lamin A expression in lung adenocarcinoma cells from pleural effusions is a pejorative factor associated with high number of metastatic sites and poor Performance status.

PLoS ONE, 2017
The type V intermediate filament lamins are the principal components of the nuclear matrix, including the nuclear lamina. Lamins are divided into A-type and B-type, which are encoded by three genes, LMNA, LMNB1, and LMNB2.
Elise Kaspi, Diane Frankel, Julien Guinde, Sophie Perrin, Sophie Laroumagne, Andrée Robaglia-Schlupp, Kevin Ostacolo, Karim Harhouri, Rachid Tazi-Mezalek, Joelle Micallef, Hervé Dutau, Pascale Tomasini, Annachiara De Sandre-Giovannoli, Nicolas Lévy, Pierre Cau, Philippe Astoul, Patrice Roll   +16 more
doaj   +2 more sources

Reciprocal knock-in mice to investigate the functional redundancy of lamin B1 and lamin B2. [PDF]

, 2014
Lamins B1 and B2 (B-type lamins) have very similar sequences and are expressed ubiquitously. In addition, both Lmnb1- and Lmnb2-deficient mice die soon after birth with neuronal layering abnormalities in the cerebral cortex, a consequence of defective ...
Coffinier, Catherine, de Jong, Pieter J, Fong, Loren G, Jung, Hea-Jin, Lee, John M, Nobumori, Chika, Tatar, Angelica, Tu, Yiping, Wu, Daniel, Yoshinaga, Yuko, Young, Stephen G   +10 more
core   +3 more sources

Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

EMBO Molecular Medicine, 2020
Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder.
Rafael Alcalá‐Vida, Marta Garcia‐Forn, Carla Castany‐Pladevall, Jordi Creus‐Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí‐Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez‐Navarro   +14 more
doaj   +2 more sources

Nuclear accumulation of UBC9 contributes to SUMOylation of lamin A/C and nucleophagy in response to DNA damage

Journal of Experimental & Clinical Cancer Research, 2019
Background Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved intracellular mechanism for lysosomal degradation of damaged cellular components.
Yunong Li, Xiuxing Jiang, Yanhao Zhang, Ziyi Gao, Yanxia Liu, Jinjiao Hu, Xiaoye Hu, Lirong Li, Jingshan Shi, Ning Gao   +9 more
doaj   +2 more sources

Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

bioRxiv, 2021
The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age-related pathologies. Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes ...
Isadora Matias, L. P. Diniz, I. Damico, Laís da Silva Neves, Ana Paula Bergamo Araujo, Gabriele Vargas, R. Leite, C. Suemoto, R. Nitrini, W. Jacob-Filho, L. Grinberg, E. Hol, J. Middeldorp, Flávia Carvalho Alcantara Gomes   +13 more
semanticscholar   +1 more source

The wide and growing range of lamin B-related diseases: from laminopathies to cancer

Cellular and Molecular Life Sciences, 2022
B-type lamins are fundamental components of the nuclear lamina, a complex structure that acts as a scaffold for organization and function of the nucleus.
C. Evangelisti, Isabella Rusciano, S. Mongiorgi, G. Ramazzotti, G. Lattanzi, L. Manzoli, L. Cocco, Stefano Ratti   +7 more
semanticscholar   +1 more source

Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway

Nucleic Acids Research, 2022
Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies.
S. Maynard, Arnaldur Hall, P. Galanos, S. Rizza, Tatsuro Yamamoto, Helena Hagner Gram, S. Munk, Muhammad Shoaib, C. Sørensen, V. Bohr, Mads Lerdrup, A. Maya-Mendoza, J. Bartek   +12 more
semanticscholar   +1 more source

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Nature Communications, 2022
Tight control of cell fate choices is crucial for normal development. Here we show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during ...
Yinuo Wang, Adel Elsherbiny, Linda Kessler, Julio Cordero, Haojie Shi, H. Serke, Olga Lityagina, F. Trogisch, M. M. Mohammadi, I. El-Battrawy, J. Backs, T. Wieland, J. Heineke, Gergana Dobreva   +13 more
semanticscholar   +1 more source

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics

bioRxiv, 2021
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms.
A. Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Y. Han, C. Park, Mark Kittisopikul, X. Wong, Joseph R. Tran, G. Gundersen, K. Reddy, G. G. Luxton, Ming Guo, J. Fredberg, Yixian Zheng, S. Adam, R. Goldman   +15 more
semanticscholar   +1 more source