Results 11 to 20 of about 52,713 (325)

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Nature Communications, 2022
Tight control of cell fate choices is crucial for normal development. Here we show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during ...
Yinuo Wang, Adel Elsherbiny, Linda Kessler, Julio Cordero, Haojie Shi, H. Serke, Olga Lityagina, F. Trogisch, M. M. Mohammadi, I. El-Battrawy, J. Backs, T. Wieland, J. Heineke, Gergana Dobreva   +13 more
semanticscholar   +1 more source

Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway

Nucleic Acids Research, 2022
Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies.
S. Maynard, Arnaldur Hall, P. Galanos, S. Rizza, Tatsuro Yamamoto, Helena Hagner Gram, S. Munk, Muhammad Shoaib, C. Sørensen, V. Bohr, Mads Lerdrup, A. Maya-Mendoza, J. Bartek   +12 more
semanticscholar   +1 more source

Unicritical laminations

Fundamenta Mathematicae, 2022
Thurston introduced \emph{invariant (quadratic) laminations} in his 1984 preprint as a vehicle for understanding the connected Julia sets and the parameter space of quadratic polynomials. Important ingredients of his analysis of the angle doubling map $ _2$ on the unit circle $\mathbb{S}^1$ were the Central Strip Lemma, non-existence of wandering ...
Bhattacharya, Sourav, Blokh, Alexander, Schleicher, Dierk   +2 more
openaire   +2 more sources

Theoretical Investigation of Structural, Electronic, and Optical Properties of ZnSnP2 Semiconductor

Annals of West University of Timisoara: Physics, 2022
The structural, electronic, and optical properties of ZnSnP2 compound were determined using the first principles calculations. We applied the full-potential enhanced plane wave method (FP-LAPW) within the framework of density functional theory (DFT) as ...
Ouledali M., Amrani B., Daoud S., Louhibi-Fasla S., Rekab-Djabri H., Beloufa N., Bekheira S., Ouadha I.   +7 more
doaj   +1 more source

Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

bioRxiv, 2021
The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age-related pathologies. Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes ...
Isadora Matias, L. P. Diniz, I. Damico, Laís da Silva Neves, Ana Paula Bergamo Araujo, Gabriele Vargas, R. Leite, C. Suemoto, R. Nitrini, W. Jacob-Filho, L. Grinberg, E. Hol, J. Middeldorp, Flávia Carvalho Alcantara Gomes   +13 more
semanticscholar   +1 more source

Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS

bioRxiv, 2022
In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to maintain nuclear structure. The nuclear lamins, the major structural components of the NL, are involved in the protection against NE rupture induced by mechanical ...
Yohei Kono, S. Adam, K. Reddy, Yixian Zheng, O. Medalia, R. Goldman, H. Kimura, T. Shimi   +7 more
semanticscholar   +1 more source

Role of C-Terminal Phosphorylation of Lamin A in DNA Damage and Cellular Senescence

Cells, 2023
The nuclear matrix protein lamin A is a multifunctional protein with roles in DNA replication and repair, gene activation, transcriptional regulation, and maintenance of higher-order chromatin structure. Phosphorylation is the main determinant of lamin A
Ying Ao, Zhuping Wu, Zhiwei Liao, Juncong Lan, Jie Zhang, Pengfei Sun, Baohua Liu, Zimei Wang   +7 more
doaj   +1 more source

Lamins [PDF]

Current Biology, 2016
Xie and Burke discuss the roles of lamins in nuclear morphology and the pathological consequences of defects in these nuclear envelope proteins.
Wei, Xie, Brian, Burke
openaire   +2 more sources

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics

bioRxiv, 2021
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms.
A. Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Y. Han, C. Park, Mark Kittisopikul, X. Wong, Joseph R. Tran, G. Gundersen, K. Reddy, G. G. Luxton, Ming Guo, J. Fredberg, Yixian Zheng, S. Adam, R. Goldman   +15 more
semanticscholar   +1 more source

The Dynamics of Lamin a During the Cell Cycle

Frontiers in Molecular Biosciences, 2021
Lamin proteins play an essential role in maintaining the nuclear organization and integrity; and lamin A, in particular, plays a major role in the whole volume of the nuclear interior.
Anat Vivante, Irit Shoval, Yuval Garini, Yuval Garini   +3 more
doaj   +1 more source