Results 11 to 20 of about 92,845 (317)

Lamin C is required to establish genome organization after mitosis

Genome Biology, 2021
Background The dynamic 3D organization of the genome is central to gene regulation and development. The nuclear lamina influences genome organization through the tethering of lamina-associated domains (LADs) to the nuclear periphery.
Xianrong Wong, Victoria E. Hoskins, Ashley J. Melendez-Perez, Jennifer C. Harr, Molly Gordon, Karen L. Reddy   +5 more
doaj   +2 more sources

Neuron type‐specific increase in lamin B1 contributes to nuclear dysfunction in Huntington’s disease

EMBO Molecular Medicine, 2020
Lamins are crucial proteins for nuclear functionality. Here, we provide new evidence showing that increased lamin B1 levels contribute to the pathophysiology of Huntington’s disease (HD), a CAG repeat‐associated neurodegenerative disorder.
Rafael Alcalá‐Vida, Marta Garcia‐Forn, Carla Castany‐Pladevall, Jordi Creus‐Muncunill, Yoko Ito, Enrique Blanco, Arantxa Golbano, Kilian Crespí‐Vázquez, Aled Parry, Guy Slater, Shamith Samarajiwa, Sandra Peiró, Luciano Di Croce, Masashi Narita, Esther Pérez‐Navarro   +14 more
doaj   +2 more sources

Loss of lamin‐B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus

bioRxiv, 2021
The increase in senescent cells in tissues, including the brain, is a general feature of normal aging and age-related pathologies. Senescent cells exhibit a specific phenotype, which includes an altered nuclear morphology and transcriptomic changes ...
Isadora Matias, L. P. Diniz, I. Damico, Laís da Silva Neves, A. P. Bergamo Araujo, Gabriele Vargas, R. Leite, C. Suemoto, R. Nitrini, W. Jacob-Filho, L. Grinberg, E. Hol, J. Middeldorp, Flávia Carvalho Alcantara Gomes   +13 more
semanticscholar   +1 more source

The wide and growing range of lamin B-related diseases: from laminopathies to cancer

Cellular and Molecular Life Sciences, 2022
B-type lamins are fundamental components of the nuclear lamina, a complex structure that acts as a scaffold for organization and function of the nucleus.
C. Evangelisti, Isabella Rusciano, S. Mongiorgi, G. Ramazzotti, G. Lattanzi, L. Manzoli, L. Cocco, Stefano Ratti   +7 more
semanticscholar   +1 more source

Lamin A/C impairments cause mitochondrial dysfunction by attenuating PGC1α and the NAMPT-NAD+ pathway

Nucleic Acids Research, 2022
Mutations in the lamin A/C gene (LMNA) cause laminopathies such as the premature aging Hutchinson Gilford progeria syndrome (HGPS) and altered lamin A/C levels are found in diverse malignancies.
Scott Maynard, Arnaldur Hall, P. Galanos, S. Rizza, Tatsuro Yamamoto, Helena Hagner Gram, S. Munk, Muhammad Shoaib, C. Sørensen, V. Bohr, Mads Lerdrup, A. Maya-Mendoza, J. Bartek   +12 more
semanticscholar   +1 more source

Lamin A/C-dependent chromatin architecture safeguards naïve pluripotency to prevent aberrant cardiovascular cell fate and function

Nature Communications, 2022
Tight control of cell fate choices is crucial for normal development. Here we show that lamin A/C plays a key role in chromatin organization in embryonic stem cells (ESCs), which safeguards naïve pluripotency and ensures proper cell fate choices during ...
Yinuo Wang, Adel Elsherbiny, Linda Kessler, Julio Cordero, Haojie Shi, H. Serke, Olga Lityagina, F. Trogisch, M. M. Mohammadi, I. El-Battrawy, J. Backs, T. Wieland, J. Heineke, G. Dobreva   +13 more
semanticscholar   +1 more source

Nucleoplasmic lamin C rapidly accumulates at sites of nuclear envelope rupture with BAF and cGAS

bioRxiv, 2022
In mammalian cell nuclei, the nuclear lamina (NL) underlies the nuclear envelope (NE) to maintain nuclear structure. The nuclear lamins, the major structural components of the NL, are involved in the protection against NE rupture induced by mechanical ...
Yohei Kono, S. Adam, K. Reddy, Yixian Zheng, O. Medalia, R. Goldman, H. Kimura, T. Shimi   +7 more
semanticscholar   +1 more source

Nuclear lamin isoforms differentially contribute to LINC complex-dependent nucleocytoskeletal coupling and whole-cell mechanics

bioRxiv, 2021
The ability of a cell to regulate its mechanical properties is central to its function. Emerging evidence suggests that interactions between the cell nucleus and cytoskeleton influence cell mechanics through poorly understood mechanisms.
A. Vahabikashi, Suganya Sivagurunathan, Fiona Ann Sadsad Nicdao, Y. Han, C. Park, Mark Kittisopikul, X. Wong, Joseph R. Tran, G. Gundersen, K. Reddy, G. G. Luxton, Ming Guo, J. Fredberg, Yixian Zheng, S. Adam, R. Goldman   +15 more
semanticscholar   +1 more source

Diversity of Nuclear Lamin A/C Action as a Key to Tissue-Specific Regulation of Cellular Identity in Health and Disease

Frontiers in Cell and Developmental Biology, 2021
A-type lamins are the main structural components of the nucleus, which are mainly localized at the nucleus periphery. First of all, A-type lamins, together with B-type lamins and proteins of the inner nuclear membrane, form a stiff structure—the nuclear ...
A. Malashicheva, K. Perepelina
semanticscholar   +1 more source

Neddylation modification regulates lamin B1 expression in breast cancer [PDF]

Zhongguo aizheng zazhi, 2022
Background and purpose: The role of neddylation modification in breast cancer has rarely been reported. Previous study found that neddylation modification blocking induced cellular senescence in breast cancer, however, the potential mechanism has not yet
JIA Xiaoqing, SUN Xiaoyin, JIANG Beiqi, MEI Zhangyi, FU Yun, ZHUANG Zhigang
doaj   +1 more source