Results 21 to 30 of about 92,845 (317)
Down-regulation of the Lamin A/C in neuroblastoma triggers the expansion of tumor initiating cells [PDF]
, 2015 Tumor-initiating cells constitute a population within a tumor mass that shares properties with normal stem cells and is considered responsible for therapy failure in many cancers.
AMENDOLA, Donatella +20 more
core +6 more sources
PCAF Involvement in Lamin A/C-HDAC2 Interplay during the Early Phase of Muscle Differentiation
Cells, 2020 Lamin A/C has been implicated in the epigenetic regulation of muscle gene expression through dynamic interaction with chromatin domains and epigenetic enzymes. We previously showed that lamin A/C interacts with histone deacetylase 2 (HDAC2).
Spartaco Santi +4 more
doaj +1 more source
Fundamenta Mathematicae, 2022 Thurston introduced \emph{invariant (quadratic) laminations} in his 1984 preprint as a vehicle for understanding the connected Julia sets and the parameter space of quadratic polynomials. Important ingredients of his analysis of the angle doubling map $ _2$ on the unit circle $\mathbb{S}^1$ were the Central Strip Lemma, non-existence of wandering ...
Bhattacharya, Sourav +2 more
openaire +2 more sources
Cold Spring Harbor Perspectives in Biology, 2010 The nuclear lamins are type V intermediate filament proteins that are critically important for the structural properties of the nucleus. In addition, they are involved in the regulation of numerous nuclear processes, including DNA replication, transcription and chromatin organization.
Thomas, Dechat +4 more
openaire +2 more sources
Lamin post-translational modifications: emerging toggles of nuclear organization and function.
TIBS -Trends in Biochemical Sciences. Regular ed, 2021 Nuclear lamins are ancient type V intermediate filaments with diverse functions that include maintaining nuclear shape, mechanosignaling, tethering and stabilizing chromatin, regulating gene expression, and contributing to cell cycle progression. Despite
Laura A Murray-Nerger, I. Cristea
semanticscholar +1 more source
Actin assembly ruptures the nuclear envelope by prying the lamina away from nuclear pores and nuclear membranes in starfish oocytes. [PDF]
, 2020 The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE) is densely packed with nuclear pore complexes (NPCs) stockpiled for embryonic development. We showed that breakdown of this specialized NE is mediated by an Arp2/3-
Avilov, I. +6 more
core +1 more source
Developmental Cell, 2020 LMNA encodes nuclear Lamin A/C that tethers lamina-associated domains (LADs) to the nuclear periphery. Mutations in LMNA cause degenerative disorders including the premature aging disorder Hutchinson-Gilford progeria, but the mechanisms are unknown.
Kohta Ikegami +4 more
semanticscholar +1 more source
Lamin A/C: Function in Normal and Tumor Cells
Cancers, 2020 Simple Summary The aim of this review is to summarize lamin A/C’s currently known functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many functions in cells, such as maintaining a cell’s structural stability, cell motility ...
N. Dubik, S. Mai
semanticscholar +1 more source
The laminA/NF-Y protein complex reveals an unknown transcriptional mechanism on cell proliferation [PDF]
, 2016 Lamin A is a component of the nuclear matrix that also controls proliferation by largely unknown mechanisms. NF-Y is a ubiquitous protein involved in cell proliferation composed of three subunits (-YA -YB -YC) all required for the DNA ...
Alonzi, Tonino +16 more
core +2 more sources
Lamins and lamin-associated proteins
Current Opinion in Cell Biology, 1994 A variety of morphological and biochemical studies have established that the nuclear lamins play an important role in nuclear structure and dynamics. Recent work reveals the existence of specialized lamin isotypes and novel pathways of modulation of lamin import into the nucleus via phosphorylation by protein kinase C.
Georgatos, S. D., Meier, J., Simos, G.
openaire +3 more sources