Results 31 to 40 of about 52,713 (325)
Journal of Cell Science, 2012 Lamins, the major components of the nuclear lamina, have gained rapidly increasing interest over the past decade as lamin mutations were found to cause numerous devastating diseases. These laminopathies include Emery–Dreifuss muscular dystrophy (EDMD), dilated cardiomyopathy type 1A, limb ...
Jan Lammerding, Chin Yee Ho
openaire +2 more sources
Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells. [PDF]
PLoS ONE, 2017 Nuclear lamins support the nuclear envelope and provide anchorage sites for chromatin. They are involved in DNA synthesis, transcription, and replication.
Ines Rauschert +7 more
doaj +1 more source
Lamin A/C: Function in Normal and Tumor Cells
Cancers, 2020 Simple Summary The aim of this review is to summarize lamin A/C’s currently known functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many functions in cells, such as maintaining a cell’s structural stability, cell motility ...
N. Dubik, S. Mai
semanticscholar +1 more source
Protein & Cell, 2020 The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions. However, the molecular machinery underlying these hierarchically organized three-dimensional (3D) chromatin ...
Lei Chang +12 more
semanticscholar +1 more source
Open Biology, 2022 Lamin A phosphorylation/de-phosphorylation is an important process during cells division as it allows for nuclear envelope (NE) disassembly at mitotic entry and its re-assembly during mitotic exit.
Florentin Huguet +4 more
doaj +1 more source
Filament assembly of the C. elegans lamin in the absence of helix 1A
Nucleus, 2022 Lamins are the major constituent of the nuclear lamina, a protein meshwork underlying the inner nuclear membrane. Nuclear lamins are type V intermediate filaments that assemble into ~3.5 nm thick filaments.
Rebecca de Leeuw +3 more
doaj +1 more source
Lamin A/C Mechanotransduction in Laminopathies
Cells, 2020 Mechanotransduction translates forces into biological responses and regulates cell functionalities. It is implicated in several diseases, including laminopathies which are pathologies associated with mutations in lamins and lamin-associated proteins ...
F. Donnaloja +3 more
semanticscholar +1 more source
Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
The Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
S. Liu, Kohta Ikegami
semanticscholar +1 more source
Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly
EMBO Reports, 2020 The nuclear lamina is essential for the structural integration of the nuclear envelope. Nuclear envelope rupture and chromatin externalization is a hallmark of the formation of neutrophil extracellular traps (NETs).
Yubin Li +5 more
semanticscholar +1 more source
Journal of Experimental & Clinical Cancer Research, 2009 Background Lamin A/C is very important in DNA replication, RNA dependent transcription and nuclear stabilization. Reduced or absent lamin A/C expression has been found to be a common feature of a variety of different cancers.
Xu Dazhi +5 more
doaj +1 more source