Results 31 to 40 of about 53,083 (269)
Regulation of Lipid Metabolism by Lamin in Mutation-Related Diseases
Frontiers in Pharmacology, 2022 Nuclear lamins, known as type 5 intermediate fibers, are composed of lamin A, lamin C, lamin B1, and lamin B2, which are encoded by LMNA and LMNB genes, respectively.
Yue Peng +4 more
doaj +1 more source
Çocukluk çağı akut myeloid lösemilerinde lamin protein gen ekspresyonu
Cukurova Medical Journal, 2018 Amaç: Bu çalışmanın amacı çocukluk çağı akut myeloid lösemilerinde (AML) hücre çoğalması ve apoptozis ile ilgili yollarla bağlantılı olduğu düşünülen lamin A/C, lamin B1 ve lamin B2 proteinlerinin gen ekspresyon durumunun saptanması ve prognoz ile olan ...
Ayşe ÖZKAN +5 more
doaj +1 more source
Lamin A/C: Function in Normal and Tumor Cells
Cancers, 2020 Simple Summary The aim of this review is to summarize lamin A/C’s currently known functions in both normal and diseased cells. Lamin A/C is a nuclear protein with many functions in cells, such as maintaining a cell’s structural stability, cell motility ...
N. Dubik, S. Mai
semanticscholar +1 more source
The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence [PDF]
Open Biology, 2016 AKTIP is a shelterin-interacting protein required for replication of telomeric DNA. Here, we show that AKTIP biochemically interacts with A- and B-type lamins and affects lamin A, but not lamin C or B, expression.
Romina Burla +14 more
doaj +1 more source
Protein & Cell, 2020 The eukaryotic genome is folded into higher-order conformation accompanied with constrained dynamics for coordinated genome functions. However, the molecular machinery underlying these hierarchically organized three-dimensional (3D) chromatin ...
Lei Chang +12 more
semanticscholar +1 more source
Lamin A/C Mechanotransduction in Laminopathies
Cells, 2020 Mechanotransduction translates forces into biological responses and regulates cell functionalities. It is implicated in several diseases, including laminopathies which are pathologies associated with mutations in lamins and lamin-associated proteins ...
F. Donnaloja +3 more
semanticscholar +1 more source
Nuclear lamin phosphorylation: an emerging role in gene regulation and pathogenesis of laminopathies
The Nucleus, 2020 Decades of studies have established that nuclear lamin polymers form the nuclear lamina, a protein meshwork that supports the nuclear envelope structure and tethers heterochromatin to the nuclear periphery.
S. Liu, Kohta Ikegami
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2023 Clinical frailty affects ∼10% of people over age 65 and is studied in a chronically inflamed (Interleukin-10 knockout; “IL10-KO”) mouse model. Frailty phenotypes overlap the spectrum of diseases (“laminopathies”) caused by mutations in LMNA. LMNA encodes
Fatima D. Elzamzami +9 more
doaj +1 more source
Modelling Fatigue Behaviours and Lifetimes of Novel GLARE Laminates under Random Loading Spectrum [PDF]
published,2023, 2023 This paper aims to experimentally and numerically probe fatigue behaviours and lifetimes of novel GLARE (glass laminate aluminium reinforced epoxy) laminates under random loading spectrum. A mixed algorithm based on fatigue damage concepts of three-phase materials was proposed for modelling progressive fatigue damage mechanisms and fatigue life of ...
arxiv +1 more source
Nuclear envelope rupture and NET formation is driven by PKCα‐mediated lamin B disassembly
EMBO Reports, 2020 The nuclear lamina is essential for the structural integration of the nuclear envelope. Nuclear envelope rupture and chromatin externalization is a hallmark of the formation of neutrophil extracellular traps (NETs).
Yubin Li +5 more
semanticscholar +1 more source