Results 71 to 80 of about 52,713 (325)

Revisiting the truncated lamin A produced by a commonly used strain of Lmna knockout mice

Nucleus, 2023
The Lmna knockout mouse (Lmna–/–) created by Sullivan and coworkers in 1999 has been widely used to examine lamin A/C function. The knockout allele contains a deletion of Lmna intron 7–exon 11 sequences and was reported to be a null allele.
Joonyoung R. Kim, Paul H. Kim, Ashley Presnell, Yiping Tu, Stephen G. Young   +4 more
doaj   +1 more source

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

Advanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam, Jiao Zhai, Heng Zou, Yu Chen, Michael Yang   +4 more
wiley   +1 more source

Statins and Histone Deacetylase Inhibitors Affect Lamin A/C – Histone Deacetylase 2 Interaction in Human Cells

Frontiers in Cell and Developmental Biology, 2019
We recently identified lamin A/C as a docking molecule for human histone deacetylase 2 (HDAC2) and showed involvement of HDAC2-lamin A/C complexes in the DNA damage response.
Elisabetta Mattioli, Elisabetta Mattioli, Davide Andrenacci, Davide Andrenacci, Antonello Mai, Sergio Valente, Joke Robijns, Winnok H. De Vos, Cristina Capanni, Cristina Capanni, Giovanna Lattanzi, Giovanna Lattanzi   +11 more
doaj   +1 more source

A Unified Linear Viscoelastic Model of the Cell Nucleus Defines the Mechanical Contributions of Lamins and Chromatin

Advanced Science, 2020
The cell nucleus is constantly subjected to externally applied forces. During metazoan evolution, the nucleus has been optimized to allow physical deformability while protecting the genome under load.
Oren Wintner, Nivi Hirsch‐Attas, Miriam Schlossberg, Fani Brofman, Roy Friedman, Meital Kupervaser, Danny Kitsberg, Amnon Buxboim   +7 more
doaj   +1 more source

Bounding laminations

Duke Mathematical Journal, 1988
Consider a hyperbolic surface S, bounding a 3-dimensional handlebody V (or, more generally, a compression body). A geodesic lamination on S is a closed union of disjoint simple geodesics. The article is concerned with the following question: When is such a lamination the Hausdorff limit of a sequence of simple closed geodesics which are homotopic to 0 ...
openaire   +3 more sources

An Injection‐Molded Modified Silicone Rubber for Cancer‐on‐Chip Applications

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This study describes the characterization and application of an injection‐molded functionalized PDMS fluidic insert for the commercially available Micronit system. Modified PDMS can accommodate cell culture and is able to covalently bind proteins for long‐lasting coatings under flow‐conditions.
Ben J. Haspels, Frederikus Bakker, Lucas J. A. M. Beckers, Roland Kanaar, Koen C. Kriege, Susanne M. Valster, Roland C. M. Vulders, Maayke M. P. Kuijten   +7 more
wiley   +1 more source

Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET

Journal of Experimental Medicine, 2019
Jia et al. demonstrate that lamin B1 acts as a tumor suppressor in lung cancer. Lamin B1 loss promotes lung cancer development and metastasis by loss of PRC2 recruitment to chromatin and activation of the RET/p38 signaling axis.
Yanhan Jia, Joaquim Si-Long Vong, Alina Asafova, B. Garvalov, Luca Caputo, Julio Cordero, Anshu Singh, T. Boettger, S. Günther, L. Fink, T. Acker, G. Barreto, W. Seeger, T. Braun, R. Savai, Gergana Dobreva   +15 more
semanticscholar   +1 more source

Laminate Veneerler

Selcuk Dental Journal, 2022
Laminate Veneerler Estetik dental tedavilerde hastaların beklenti ve gereksinimleri günden güne artmaktadır. Dental estetik, hastaların kaybettikleri estetik görüntünün yeniden kazandırılmasında son derece önemli bir yer tutmaktadır. Hasta beklentilerinin bu denli yüksek olması, hekimleri tedavilerde daha estetik materyaller kullanmaya ve daha hassas ...
Emre SİVA, Hakan TERZİOGLU
openaire   +3 more sources

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

Advanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang, Yan Wang, Shanhu Cao, Shelly M. Xie, Bei Liu, Yimeng Li, Yuqi Hou, Xue Meng, Mingzhu Ruan, Di Bu, Jia Kang, Ruxin Li, Lei Lou, Juan Wang, Lingxiao Xing   +14 more
wiley   +1 more source

The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy

Nature Communications, 2019
Mutations in LMNA, which encodes the nuclear proteins Lamin A/C, can cause cardiomyopathy and conduction disorders. Here, we employ induced pluripotent stem cells (iPSCs) generated from human cells carrying heterozygous K219T mutation on LMNA to develop ...
N. Salvarani, Silvia Crasto, M. Miragoli, Alessandro Bertero, Marianna Paulis, P. Kunderfranco, Simone Serio, Alberto Forni, C. Lucarelli, M. dal Ferro, V. Larcher, G. Sinagra, Paolo Vezzoni, Charles E. Murry, G. Faggian, G. Condorelli, E. Di Pasquale   +16 more
semanticscholar   +1 more source