Results 41 to 50 of about 21,188,703 (341)

Dysfunctional polycomb transcriptional repression contributes to Lamin A/C dependent muscular dystrophy.

Journal of Clinical Investigation, 2020
Lamin A is a component of the inner nuclear membrane that, together with epigenetic factors, organizes the genome in higher order structures required for transcriptional control.
Andrea Bianchi, C. Mozzetta, Gloria Pegoli, F. Lucini, Sara Valsoni, V. Rosti, C. Petrini, A. Cortesi, Francesco Gregoretti, Laura Antonelli, Gennaro Oliva, Marco De Bardi, R. Rizzi, B. Bodega, Diego Pasini, F. Ferrari, C. Bearzi, C. Lanzuolo   +17 more
semanticscholar   +1 more source

Pushing the (nuclear) envelope into meiosis. [PDF]

, 2013
A recent study shows that a short isoform of a mammalian nuclear lamin is important for homologous chromosome interactions during meiotic prophase in ...
Dernburg, Abby F
core   +1 more source

Lamin A safeguards the m6A methylase METTL14 nuclear speckle reservoir to prevent cellular senescence

Aging Cell, 2020
Mutations in LMNA gene are frequently identified in patients suffering from a genetic disorder known as Hutchison–Gilford progeria syndrome (HGPS), providing an ideal model for the understanding of the mechanisms of aging. Lamin A, encoded by LMNA, is an
Jie Zhang, Ying Ao, Zhen Zhang, Yanzhen Mo, Linyuan Peng, Yue Jiang, Zimei Wang, Baohua Liu   +7 more
semanticscholar   +1 more source

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes [PDF]

, 2015
Beyond its role in providing structure to the nuclear envelope, lamin A/C is involved in transcriptional regulation. However, its cross talk with epigenetic factors--and how this cross talk influences physiological processes--is still unexplored.
Alessio Zippo, Alice Cortesi, Annagiusi Gargiulo, Asp, Ball, Bantignies, Bantignies, Beard, Beatrice Bodega, Bolte, Breiling, Caretti, Carpenter, Chiara Lanzuolo, Chiara Mozzetta, Cmarko, Cohen, Collas, Collins, Daniela Palacios, Delest, Dialynas, Elisa Cesarini, Fabrizia Marullo, Favreau, Francesco Gregoretti, Fredriksson, Frock, Gennaro Oliva, Gruenbaum, Gruenbaum, Harr, He, Hozák, Huang, Jahn, Juan, Kind, Kolb, Lanzuolo, Lanzuolo, Lanzuolo, Laura Antonelli, Lee, Lo Sardo, Lund, Marta Columbaro, Masny, Mattout, McCord, Melcon, Moir, Muñoz-Alarcón, Méjat, Oldenburg, Otsu, Palacios, Paro, Relaix, Riemer, Rosenblatt, Russ, Röber, Satijn, Scaffidi, Schiaffino, Schuettengruber, Schulze, Sezgin, Shimi, Shumaker, Simona Di Pelino, Solovei, Stefano Squarzoni, Stewart, Sullivan, Tolhuis, Trapnell, Wang, Wang, Woodhouse, Zaremba-Czogalla, Zwerger, Šmigová   +83 more
core   +1 more source

Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery–Dreifuss Muscular Dystrophy

Cells, 2020
LMNA encodes for Lamin A/C, type V intermediate filaments that polymerize under the inner nuclear membrane to form the nuclear lamina. A small fraction of Lamin A/C, less polymerized, is also found in the nucleoplasm. Lamin A/C functions include roles in
A. Bertrand, A. Brull, F. Azibani, L. Benarroch, K. Chikhaoui, C. Stewart, O. Medalia, R. Ben Yaou, G. Bonne   +8 more
semanticscholar   +1 more source

Mammalian telomeres and their partnership with lamins [PDF]

, 2016
Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins.
BURLA, ROMINA, LA TORRE, MATTIA, SAGGIO, Isabella   +2 more
core   +1 more source

Differential expression of nuclear lamin subtypes in the neural cells of the adult rat cerebral cortex

IBRO Reports, 2018
Lamins are type V intermediate filament proteins that are located beneath the inner nuclear membrane. In mammalian somatic cells, LMNB1 and LMNB2 encode somatic lamins B1 and B2, respectively, and the LMNA gene is alternatively spliced to generate ...
Yasuharu Takamori, Yukie Hirahara, Taketoshi Wakabayashi, Tetsuji Mori, Taro Koike, Yosky Kataoka, Yasuhisa Tamura, Shuji Kurebayashi, Kiyoshi Kurokawa, Hisao Yamada   +9 more
doaj   +1 more source

Surface Roughness Gradients Reveal Topography‐Specific Mechanosensitive Responses in Human Mesenchymal Stem Cells [PDF]

, 2020
The topographic features of an implant, which mechanically regulate cell behaviors and functions, are critical for the clinical success in tissue regeneration.
Camacho, Luis Cuellar, Haag, Rainer, Hou, Yong, Nie, Chuanxiong, Wei, Qiang, Xie, Wenyan, Yu, Leixiao, Zhang, Man   +7 more
core   +1 more source

Native lamin A/C proteomes and novel partners from heart and skeletal muscle in a mouse chronic inflammation model of human frailty

Frontiers in Cell and Developmental Biology, 2023
Clinical frailty affects ∼10% of people over age 65 and is studied in a chronically inflamed (Interleukin-10 knockout; “IL10-KO”) mouse model. Frailty phenotypes overlap the spectrum of diseases (“laminopathies”) caused by mutations in LMNA. LMNA encodes
Fatima D. Elzamzami, Arushi Samal, Adith S. Arun, Tejas Dharmaraj, Neeti R. Prasad, Alex Rendon-Jonguitud, Lauren DeVine, Jeremy D. Walston, Robert N. Cole, Katherine L. Wilson   +9 more
doaj   +1 more source

Porcelain Laminate Veneers: A Case Report

Cureus, 2023
One of the most crucial issues in modern dentistry is restoring a patient's lost dental aesthetic appearance. To do this, new therapeutic tools and techniques have been appearing on the market day by day. For anterior teeth, where aesthetics are extremely essential, the majority of dentists prefer more conservative and aesthetic treatments, such as ...
Minase, Dhanashree A, Sathe, Seema, Bhoyar, Anjali, Dahihandekar, Chinmayee, Jaiswal, Tanvi   +4 more
openaire   +2 more sources