Results 81 to 90 of about 21,188,703 (341)

SPANX Control of Lamin A/C Modulates Nuclear Architecture and Promotes Melanoma Growth

Molecular Cancer Research, 2020
Mechanisms regulating nuclear organization control fundamental cellular processes, including the cell and chromatin organization. Their disorganization, including aberrant nuclear architecture, has been often implicated in cellular transformation.
I. Lazar, Bertrand Fabre, Yongmei Feng, Ali Khateb, P. Turko, J. M. Martínez Gómez, Dennie T. Frederick, M. Levesque, Lea Feld, Gao Zhang, Tongwu Zhang, B. James, J. Shklover, E. Avitan-Hersh, Ido Livneh, M. Scortegagna, K. Brown, O. Larsson, I. Topisirovic, Haguy Wolfenson, M. Herlyn, K. Flaherty, R. Dummer, Z. Ronai   +23 more
semanticscholar   +1 more source

Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity [PDF]

, 2013
The NAD+-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies ...
Chen GL, Pattison D, Wang H, Yoshida M
core   +1 more source

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Drosophila nuclear lamin precursor Dm0 is translated from either of two developmentally regulated mRNA species apparently encoded by a single gene. [PDF]

, 1988
A cDNA clone encoding a portion of Drosophila nuclear lamins Dm1 and Dm2 has been identified by screening a lambda-gt11 cDNA expression library using Drosophila lamin-specific monoclonal antibodies.
Bare, JW, Benton, BM, Drees, B, Fisher, PA, Gruenbaum, Y, Landesman, Y, Paddy, MR, Saumweber, H, Sedat, JW, Smith, DE   +9 more
core   +1 more source

Cancer Cells Traverse Faster in Confined Space by Modifying Vimentin filaments With Nuclear Deformation and Promoting the Growth of Desired Tumor Spheroids

Advanced Materials Interfaces, EarlyView.
This study demonstrates how the Vimentin intermediate (VIM) filaments distribution/density regulates the attainment of different migration modes through cytoskeleton rearrangement and controls the nuclear morphology in migrating cells under physical confinement, which facilitates the faster traversing of those cells and the growth of post‐migration ...
Md Kowsar Alam, Jiao Zhai, Heng Zou, Yu Chen, Michael Yang   +4 more
wiley   +1 more source

Journal of African Christian Biography: v. 4, no. 2 [PDF]

, 2019
A publication of the Dictionary of African Christian Biography with U.S. offices located at the Center for Global Christianity and Mission at Boston University. This issue focuses on: 1.
Bonk, Jonathan J., Bratt, David, Oborji, Frances Anekwe, Restrick, Beth, Sanneh, Lamin, Sigg, Michèle Miller, Walls, Andrew, Watters, John R.   +7 more
core  

Leichtlösliche, lichtechte Perylen-Fluoreszenzfarbstoffe [PDF]

, 1988
Die Synthese von Perylenfarbstoffen 2 mit terminalen Alkylgruppen wird beschrieben. Langkettige n-Alkylgruppen führen nicht zu einer Erhöhung der Löslichkeit, sondern zu einer Erniedrigung.
Adkins, Aubert, Kitatsuji, Langhals, Langhals, Langhals, Langhals, Niobe, Pohland, Prelog, Rademacher, Rohrmann, Sadrai, Černý   +13 more
core   +1 more source

An Injection‐Molded Modified Silicone Rubber for Cancer‐on‐Chip Applications

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This study describes the characterization and application of an injection‐molded functionalized PDMS fluidic insert for the commercially available Micronit system. Modified PDMS can accommodate cell culture and is able to covalently bind proteins for long‐lasting coatings under flow‐conditions.
Ben J. Haspels, Frederikus Bakker, Lucas J. A. M. Beckers, Roland Kanaar, Koen C. Kriege, Susanne M. Valster, Roland C. M. Vulders, Maayke M. P. Kuijten   +7 more
wiley   +1 more source

Coordinated increase of nuclear tension and lamin-A with matrix stiffness outcompetes lamin-B receptor that favors soft tissue phenotypes

Molecular Biology of the Cell, 2017
Tissue profiles and MSC transcriptomics separately indicate that LBR varies inversely with lamin-A,C. Such anti-correlations are recapitulated in MSC adipogenesis and osteogenesis as well as with matrix elasticity, knockdowns, overexpression, and myosin ...
A. Buxboim, J. Irianto, J. Swift, Avathamsa Athirasala, Jae-Won Shin, F. Rehfeldt, D. Discher   +6 more
semanticscholar   +1 more source

Chromosome positioning is largely unaffected in lymphoblastoid cell lines containing emerin or A-type lamin mutations [PDF]

, 2005
Gene-poor human chromosomes are reproducibly found at the nuclear periphery in proliferating cells. There are a number of inner nuclear envelope proteins that may have roles in chromosome location and anchorage, e.g. emerin and A-type lamins.
Bridger, JM, Levy, N, Meaburn, KJ, Toniolo, D   +3 more
core   +1 more source