Results 161 to 170 of about 9,725,288 (229)

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Single‐Sensor Vibration Sensing in Anisotropic Composites Enabled by Disordered Metasurfaces

Advanced Science, EarlyView.
This work develops a single‐sensor vibration sensing (SSVS) framework that integrates disordered metasurfaces with compressive sensing. Comprehensive numerical and experimental validations demonstrate that, by manipulating anisotropic guided wave propagation through metasurfaces, the proposed SSVS framework enables high‐fidelity multi‐source vibration ...
Jianjie Zhang, Lanhe Xu, Zhongzheng Zhang, Yongbo Li, Eric Li, Asoke K. Nandi, Bing Li   +6 more
wiley   +1 more source

Multiple Modes of Action of Anti-TNF-α Antibodies for Inflammatory Bowel Diseases Beyond TNF-α Neutralization. [PDF]

Antibodies (Basel)
Watanabe T, Kudo M.
europepmc   +1 more source

Trace Li Pre‐Doping of Activated Carbon Cathode Enabling Accelerated Li‐Ion Transport for High‐Power Lithium‐Ion Capacitors

Advanced Science, EarlyView.
Trace‐level Li pre‐doping on activated carbon cathodes is demonstrated to significantly enhance Li‐ion transport and high‐rate performance in lithium‐ion capacitors. An ultrathin Li2CO3 interfacial layer, formed through controlled thermal conversion, facilitates rapid ion transport without pore blockage.
Kyungmin Do, Jihyeon Ryu, Dong Gyun Im, Seong‐Yong Kim, Tae‐Hyun Kwon, Byeong Guk Kim, Seojin Jeon, Woosun Jang, Myoung Joon Hwang, Ki‐Hun Nam, Seung Yol Jeong, Ick‐Jun Kim, Seungwook Eom, Jaeik Hyun, Sunhye Yang   +14 more
wiley   +1 more source

Gravity as a Boundary Condition for the Evolution of Three-Dimensional Multicellularity. [PDF]

Life (Basel)
Ullrich O, Thiel CS.
europepmc   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Visual Field Progression Rate and Laminar Depth and Curvature in the African Descent and Glaucoma Evaluation Study (ADAGES). [PDF]

Transl Vis Sci Technol
Murillo K, Jiravarnsirikul A, Walker E, Fazio MA, Gardiner S, Weinreb RN, Liebmann JM, Zangwill LM, Girkin CA.   +8 more
europepmc   +1 more source

Architecture‐Engineered Semi‐Crystalline Microporous Polymer Membranes for Precise Molecular Separation

Advanced Science, EarlyView.
Guided by a Random Forest model, a π–π‐driven ordered stacking strategy deploys functionally distinct substructures to restrict chain segment motion and increase free volume, while preserving the intermolecular interactions that maintain structural integrity.
Zi‐Meng Xu, Hao Zhuo, Song‐Hui Zhi, Xiao‐Feng Zhong, Pan‐Pan Zhang, Si‐Yuan Yang, Wen‐Yong Yang, Guang‐Yong Shen, Ya‐Zhao Li, Yi Li, Ming Xue   +10 more
wiley   +1 more source

NAT10 inhibition corrects nuclear defects in tau mutant human neurons and extends lifespan in a <i>Drosophila</i> tauopathy model. [PDF]

iScience
Paonessa F, Bizzini BD, Campbell T, Coode E, Lam J, Solanki R, Butler R, Smith J, Davidson CM, Larrieu D, Brand AH, Livesey FJ.   +11 more
europepmc   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source