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Gene Regulatory Interactions at Lamina-Associated Domains
Genes, 2023 The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside in local euchromatic contexts and are expressed.
Mohamed Abdelhalim +2 more
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Lamina-associated domains: Tethers and looseners
Current Opinion in Cell Biology, 2022 Lamina-associated domains (LADs) are large heterochromatic regions that are positioned at the nuclear lamina (NL). A major question is how LAD-NL interactions are mediated and controlled.
Bas van Steensel, Lise Dauban
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Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression [PDF]
Cell, 2017 In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression ...
Bas van Steensel, Andrew S Belmont
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Choreography of lamina-associated domains: structure meets dynamics
FEBS Letters, 2023Lamina‐associated domains are large regions of heterochromatin positioned at the nuclear periphery. These domains have been implicated in gene repression, especially in the context of development. In mammals, LAD organization is dependent on nuclear lamins, inner nuclear membrane proteins, and chromatin state.
Katherine L Wilson, Karen L Reddy
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Molecular Cell, 2022 Raw files for microscopy and western blot data presented in this study.*AR. Barutcu and M. Wu equally contributed to this study.SUMMARYThe nucleus is highly compartmentalized through the formation of distinct classes of membraneless domains, yet the ...
Ulrich Braunschweig +2 more
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CTCF supports preferentially short lamina-associated domains
Chromosome Research, 2022More than one third of the mammalian genome is in a close association with the nuclear lamina, thus these genomic regions were termed lamina-associated domains (LADs). This association is fundamental for many aspects of chromatin biology including transcription, replication, and DNA damage repair.
Lukasz Stanislaw Kaczmarczyk +4 more
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Chromatin protein complexes involved in gene repression in lamina-associated domains
EMBO JournalAbstract Lamina-associated domains (LADs) are large chromatin regions that are associated with the nuclear lamina (NL) and form a repressive environment for transcription. The molecular players that mediate gene repression in LADs are currently unknown.
Tom van Schaik +2 more
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Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin [PDF]
FEBS Journal, 1998 Lamina‐associated polypeptide (LAP)2, which directly interacts with B‐type lamins and chromosomes, is an integral membrane protein specifically distributed along the inner nuclear membrane of the nuclear envelope. Multiple regions of its large nucleoplasmic domain promote this localization, including the first (residues 1−296) and the second (residues ...
Takao Kondō, Kazuhiro Furukawa
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Genome regulation at the peripheral zone: lamina associated domains in development and disease
Current Opinion in Genetics & Development, 2014The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and overall three-dimensional architecture
Teresa R, Luperchio +2 more
openaire +2 more sources