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Gene Regulatory Interactions at Lamina-Associated Domains

Genes, 2023
The nuclear lamina provides a repressive chromatin environment at the nuclear periphery. However, whereas most genes in lamina-associated domains (LADs) are inactive, over ten percent reside in local euchromatic contexts and are expressed. How these genes are regulated and whether they are able to interact with regulatory elements remain unclear. Here,
M Abdelhalim, Philippe Collas, Sarah Hazell Pickering   +2 more
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Choreography of lamina‐associated domains: structure meets dynamics

FEBS Letters, 2023
Lamina‐associated domains are large regions of heterochromatin positioned at the nuclear periphery. These domains have been implicated in gene repression, especially in the context of development. In mammals, LAD organization is dependent on nuclear lamins, inner nuclear membrane proteins, and chromatin state.
Nicholas S. Alagna, Tiera I. Thomas, Katherine L. Wilson, Karen L. Reddy   +3 more
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CTCF supports preferentially short lamina-associated domains

Chromosome Research, 2022
More than one third of the mammalian genome is in a close association with the nuclear lamina, thus these genomic regions were termed lamina-associated domains (LADs). This association is fundamental for many aspects of chromatin biology including transcription, replication, and DNA damage repair.
Lukasz Stanislaw Kaczmarczyk, Nehora Levi, Tamar Segal, Mali Salmon-Divon, Gabi Gerlitz   +4 more
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Lamina-Associated Domains: Links with Chromosome Architecture, Heterochromatin, and Gene Repression [PDF]

Cell, 2017
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize chromosomes inside the nucleus and have been associated with gene repression.
Bas Van Steensel, Andrew Belmont
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Identification of the lamina-associated-polypeptide-2-binding domain of B-type lamin [PDF]

FEBS Journal, 1998
Lamina‐associated polypeptide (LAP)2, which directly interacts with B‐type lamins and chromosomes, is an integral membrane protein specifically distributed along the inner nuclear membrane of the nuclear envelope. Multiple regions of its large nucleoplasmic domain promote this localization, including the first (residues 1−296) and the second (residues ...
K, Furukawa, T, Kondo
exaly   +3 more sources

Genome regulation at the peripheral zone: lamina associated domains in development and disease

Current Opinion in Genetics & Development, 2014
The nuclear periphery has been implicated in gene regulation and it has been proposed that proximity to the nuclear lamina and inner nuclear membrane (INM) leads to gene repression. More recently, it appears that there is a correlation and interdependence between lamina associated domains (LADs), the epigenome and overall three-dimensional architecture
Teresa R, Luperchio, Xianrong, Wong, Karen L, Reddy   +2 more
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Caspase-mediated cleavage of the chromosome-binding domain of lamina-associated polypeptide 2α

Journal of Cell Science, 2000
ABSTRACT Lamina-associated polypeptide 2α (LAP2α) is a non-membrane-bound isoform of the LAP2 family involved in nuclear structure organization. Using various cell systems, including Jurkat, HL-60, and HeLa cells, and different death-inducing agents, such as anti-Fas antibody, topoisomerase inhibitors, and staurosporine, we found that ...
J, Gotzmann, S, Vlcek, R, Foisner
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Nonspecific steric hindrance of protein particles by lamina-associated domains

Genomic organization within the nucleus is crucial for gene regulation and cell health, as disruptions in this organization are linked to genetic disorders and cancers. Recent studies suggest that molecular-scale organization of chromatin near the nuclear periphery (lamina-associated domains, LADs) affects gene regulation, providing transciptional ...
Naz Bardakcı, Aykut Erbaş, Ozan S. Sarıyer   +2 more
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Substructure and maturation of lamina-associated domains in neurons of the developing and adult human brain

Summary Approximately 30-40% of the human genome is anchored to the nuclear lamina (NL) through variably sized (10 kb-10 Mb) lamina-associated domains (LADs), which can be classified into two subtypes (T1 and T2) based on their level of lamina-association.
Chujing Zhang, Eugene Gil, Sajad Hamid Ahanger, Lynn Mingcong Li, Li Wang, Eric J. Huang, Jingjing Li, Arnold R. Kriegstein, Daniel A. Lim   +8 more
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