Results 91 to 100 of about 5,061 (213)
Nuclear Organization in Stress and Aging
Cells, 2019 The eukaryotic nucleus controls most cellular processes. It is isolated from the cytoplasm by the nuclear envelope, which plays a prominent role in the structural organization of the cell, including nucleocytoplasmic communication, chromatin positioning,
Raquel Romero-Bueno +4 more
doaj +1 more source
Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture
Advanced Science, Volume 12, Issue 28, July 24, 2025.This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis +7 more
wiley +1 more source
Myonuclear alterations associated with exercise are independent of age in humans
The Journal of Physiology, Volume 603, Issue 13, Page 3755-3775, 1 July 2025.Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey +15 more
wiley +1 more source
ESC Heart FailureAims LMNA‐related dilated cardiomyopathy (DCM) is a rare disease with an incompletely defined phenotype. The phase 3 REALM‐DCM trial evaluated a potential disease‐modifying therapy for LMNA‐related DCM but was terminated due to futility without safety ...
Pablo Garcia‐Pavia +12 more
doaj +1 more source
Progeria, a model for accelerated aging exhibited by HIV patients? [PDF]
, 2010 International audienceTo confirm, among HIV1-infected patients, data from in vitro studies showing that antiretroviral therapies (ART) induce an accelerated aging through the same mechanism than genetic laminopathies (progeria) and «physiological » aging,
Pierre Cau
core +1 more source
Les lipodystrophies secondaires aux traitements antirétroviraux de l’infection par le VIH [PDF]
, 2006 Les traitements antirétroviraux de l’infection par le VIH sont responsables d’effets secondaires parfois sévères qui touchent en priorité le tissu adipeux, modifiant sa localisation (lipodystrophie avec lipoatrophie périphérique et hypertrophie centrale)
Bastard, Jean-Philippe +7 more
core +2 more sources
The Emerging Role of Lamin C as an Important LMNA Isoform in Mechanophenotype
Frontiers in Cell and Developmental Biology, 2018 Lamin A and lamin C isoforms of the gene LMNA are major structural and mechanotransductive components of the nuclear lamina. Previous reports have proposed lamin A as the isoform with the most dominant contributions to cellular mechanophenotype. Recently,
Rafael D. González-Cruz +3 more
doaj +1 more source
, 2015 We perform a statistical study of the distances between successive occurrencies of a given dinucleotide in the DNA sequence for a number of organisms of different complexity.
Castellani, Gastone C. +6 more
core +1 more source
The laminopathies: nuclear structure meets disease
Current Opinion in Genetics & Development, 2003 Most inherited diseases are associated with mutations in a specific gene. Sometimes, mutations in two or more different genes result in diseases with a similar phenotype. Rarely do different mutations in the same gene result in a multitude of seemingly different and unrelated diseases.
Cancer and Developmental Biology Laboratory, National Cancer Institute at Frederick, PO Box B, Frederick, Maryland 21702, USA ( host institution ) +4 more
openaire +3 more sources