Results 81 to 90 of about 5,061 (213)

Cardiac involvement in laminopathies [PDF]

Orphanet Journal of Rare Diseases, 2015
Lamin A/C gene mutations can be associated with myocardial diseases, usually characterized by dilated cardiomyopathy and/or arrhythmic disorders. Phenotypic penetrance is age-related but expression is extremely heterogeneous, so that muscular and arrhythmic disease can be present in combination in the same patient, or one phenotypic manifestation can ...
Boriani, Giuseppe, Biagini, Elena, Wahbi, Karim, Duboc, Denis   +3 more
openaire   +1 more source

Cytokine Profile in Striated Muscle Laminopathies: New Promising Biomarkers for Disease Prediction

Cells, 2020
Laminopathies are a wide and heterogeneous group of rare human diseases caused by mutations of the LMNA gene or related nuclear envelope genes. The variety of clinical phenotypes and the wide spectrum of histopathological changes among patients carrying ...
Cristina Cappelletti, Irene Tramacere, Paola Cavalcante, Elisa Schena, Luisa Politano, Nicola Carboni, Alessandra Gambineri, Adele D’Amico, Lucia Ruggiero, Giulia Ricci, Gabriele Siciliano, Giuseppe Boriani, Tiziana Enrica Mongini, Liliana Vercelli, Elena Biagini, Matteo Ziacchi, Maria Rosaria D’Apice, Giovanna Lattanzi, Renato Mantegazza, Lorenzo Maggi, Pia Bernasconi   +20 more
doaj   +1 more source

cTAGE5/MEA6 Regulates LBR Localization to Maintain Nuclear Envelope Integrity and Safeguard Against Aging

Aging Cell, Volume 24, Issue 10, October 2025.
cTAGE5 regulates LBR trafficking between the ER and the nucleus membrane to maintain the integrity of both the ER and the nuclear envelope. cTAGE5 KO results in LBR retention in the ER, reduced stability, and subsequent disruption of nuclear envelope integrity. ABSTRACT cTAGE5/MEA6 plays a pivotal role in COPII complex assembly, ER‐to‐Golgi trafficking,
Yaqing Wang, Pengyu Sun, Fuqiang Yang, Tiantian Ma, Junwan Fan, Lei Shi, Nan Li, Fei Gao, Kangmin He, Zhiheng Xu   +9 more
wiley   +1 more source

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies

European Journal of Histochemistry, 2009
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi, G Lattanzi, C Capanni, M Columbaro, L Merlini, E Mattioli, P Sabatelli   +6 more
doaj   +1 more source

Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer [PDF]

, 2016
Epithelial–mesenchymal transition (EMT) is a key event that is involved in the invasion and dissemination of cancer cells. Although typically considered as having tumour-suppressive properties, transforming growth factor (TGF)-β signalling is altered ...
A G Pockley, A K Miles, A Kakizuka, B Terris, BR Henderson, C Gurrieri, C Johnson, CD Morrison, CH Heldin, D G Powe, D J Boocock, DG Altman, DR Principe, G Hulman, G Jin, G van Schalkwyk, H de Thé, H Son, HK Lin, J Borrow, J Hulman, J Massagué, J Massagué, JJ Christiansen, JP Thiery, Jr McCarty KS, JYH Chan, L Kubiczkova, M E Buczek, M Mazza, MG Mathieu, P Salomoni, PM Siegel, R C Rees, R Derynck, R Parkinson, RL Camp, S Grünert, S Lamouille, S Nisole, T Regad, T Regad, V Lallemand-Breitenbach, W Green, WC Yuan, Y Katakura   +45 more
core   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, Volume 35, Issue 38, September 18, 2025.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Identification of Genes and Pathways Regulated by Lamin A in Heart

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020
Background Mutations in the LMNA gene, encoding LMNA (lamin A/C), causes distinct disorders, including dilated cardiomyopathies, collectively referred to as laminopathies. The genes (coding and noncoding) and regulatory pathways controlled by LMNA in the
Jordi Coste Pradas, Gaelle Auguste, Scot J. Matkovich, Raffaella Lombardi, Suet Nee Chen, Tyrone Garnett, Kyle Chamberlain, Jalish Mahmud Riyad, Thomas Weber, Sanjay K. Singh, Matthew J. Robertson, Cristian Coarfa, Ali J. Marian, Priyatansh Gurha   +13 more
doaj   +1 more source

Mapping of cell nuclei based on contour warping [PDF]

, 2010
The dynamics of genome regions are associated to the functional or dysfunctional behaviour of the human cell. In order to study these dynamics it is necessary to remove all perturbations coming from movement and deformation of the nucleus, i.e.
De Vos, Winnok, De Vylder, Jonas, Philips, Wilfried   +2 more
core  

Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes [PDF]

, 2015
Beyond its role in providing structure to the nuclear envelope, lamin A/C is involved in transcriptional regulation. However, its cross talk with epigenetic factors--and how this cross talk influences physiological processes--is still unexplored.
Alessio Zippo, Alice Cortesi, Annagiusi Gargiulo, Asp, Ball, Bantignies, Bantignies, Beard, Beatrice Bodega, Bolte, Breiling, Caretti, Carpenter, Chiara Lanzuolo, Chiara Mozzetta, Cmarko, Cohen, Collas, Collins, Daniela Palacios, Delest, Dialynas, Elisa Cesarini, Fabrizia Marullo, Favreau, Francesco Gregoretti, Fredriksson, Frock, Gennaro Oliva, Gruenbaum, Gruenbaum, Harr, He, Hozák, Huang, Jahn, Juan, Kind, Kolb, Lanzuolo, Lanzuolo, Lanzuolo, Laura Antonelli, Lee, Lo Sardo, Lund, Marta Columbaro, Masny, Mattout, McCord, Melcon, Moir, Muñoz-Alarcón, Méjat, Oldenburg, Otsu, Palacios, Paro, Relaix, Riemer, Rosenblatt, Russ, Röber, Satijn, Scaffidi, Schiaffino, Schuettengruber, Schulze, Sezgin, Shimi, Shumaker, Simona Di Pelino, Solovei, Stefano Squarzoni, Stewart, Sullivan, Tolhuis, Trapnell, Wang, Wang, Woodhouse, Zaremba-Czogalla, Zwerger, Šmigová   +83 more
core   +1 more source

Aging and Altered Gravity: A Cellular Perspective

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
We propose that, unlike biological aging, where Primary hallmarks initiate damage, spaceflight may trigger a feedback loop between Antagonistic and Integrative hallmarks, driving accelerated aging. Returning to 1 g restores proper signaling and breaks the cycle.
Sharon van Rijthoven, Jack J. W. A. van Loon   +1 more
wiley   +1 more source