Results 61 to 70 of about 3,734 (156)

Nuclear Entanglement: New Insights Into the Role of Cytoskeleton and Nucleoskeleton in Plant Nuclear Function

Cytoskeleton, Volume 83, Issue 6, Page 354-375, June 2026.
ABSTRACT Of the three types of cytoskeleton known in animals—actin, microtubules, and intermediate filaments—only actin and microtubules exist in plants. Both play important roles in cellular shaping, organelle movement, organization of the endomembrane system, and cell signaling.
Norman R. Groves, Katelyn Amstutz, Lily A. Schumacher, Iris Meier   +3 more
wiley   +1 more source

Understanding Molecular Mechanisms of Striated Muscle Laminopathies Using Cellular and Zebrafish Models

, 2020
The Lamin A/C (LMNA) gene codes for the A-type lamins which are nuclear intermediate filaments that provide structural support to the nucleus and help regulate various nuclear processes such as gene expression. Mutations in LMNA cause a group of diseases
Nicolas, Hannah Almira
core   +1 more source

Severe cardiac valvular calcification in two Chinese brothers with mandibuloacral dysplasia type A: a case report

Frontiers in Cardiovascular Medicine
Mandibuloacral dysplasia type A (MADA) is a rare progeroid syndrome associated with mutations in the Lamin A/C (LMNA) gene, primarily affecting skeletal, cutaneous, and adipose tissues.
Yi Guo, Xinyi Zhang, Yanfei Meng, Qiuzhe Guo, Xiaoqi Wang   +4 more
doaj   +1 more source

Lamin B1 safeguards the B cell genome and shapes lymphoma outcome

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Lamin B1 is a structural component of the nuclear lamina that participates in genome organization and transcriptional control. During adaptive immune responses, B lymphocytes in germinal centers (GCs) undergo clonal expansion and programmed DNA damage at immunoglobulin loci, while simultaneously downregulating Lamin B1.
Filip Filipsky, Katarina B. Chapman, Johannes Bloehdorn, Oscar Maiques, Abigail Lee, Andrew Clear, Jun Wang, John Gribben, Michael Hausmann, Christoph Cremer, Andrejs Braun, Marta C. Sallan, Tanya Klymenko   +12 more
wiley   +1 more source

Electro‐Mechanical Dissociation in Chagas Cardiomyopathy: Comparative Analysis of Arrhythmic Burden Beyond LVEF

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Despite matched clinical characteristics and LVEF, patients with Chagas cardiomyopathy exhibit a significantly higher arrhythmic burden compared to ischemic cardiomyopathy. This electro‐mechanical dissociation highlights the necessity of sudden death risk stratification strategies that extend beyond traditional ejection fraction thresholds.
Luis E. Echeverría, Lyda Z. Rojas, Angie Yarlady Serrano‐García, Yina T. Ariza, Carlos Luengas, Rachel Marcus, Carlos A. Morillo, Sergio A. Gómez‐Ochoa   +7 more
wiley   +1 more source

Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers

Cells, 2020
Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes.
Michael Blank
doaj   +1 more source

Current Topics of Progressive Cardiac Conduction Disease

Journal of Arrhythmia, Volume 42, Issue 3, June 2026.
Many genes and the protein cause PCCD. Mutation of NaV1.5 or CX40 cause isolated PCCD, but mutation of lamin A/C, emerin, or desmin lead to cardiomyopathy, and PCCD. Mutation of transcription factor NCX2‐5, and Tbx5 associated with atrial septal defect and abnormal development of conduction system.
Naokata Sumitomo, Hitoshi Mori, Takashi Kumamoto, Taisuke Ishikawa, Akiko Seki, Naomasa Makita, Jean‐Jacques Schott, Arthur A. M. Wilde   +7 more
wiley   +1 more source

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies

European Journal of Histochemistry, 2009
The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi, G Lattanzi, C Capanni, M Columbaro, L Merlini, E Mattioli, P Sabatelli   +6 more
doaj   +1 more source

Metabolic Profiling Reveals Organ‐Specific Molecular Pathologies and Aging‐Associated Biomarkers in Progeroid Laminopathy

Smart Medicine, Volume 5, Issue 3, June 2026.
This study integrates transcriptomic, lipidomic, and metabolomic profiling of the heart, lung, skin, and serum from Hutchinson–Gilford progeria syndrome (HGPS) mouse models and human progeroid laminopathy (PL) cohorts. Through multi‐organ analyses, we reveal organ‐specific aging signatures, and importantly, cross‐species serum metabolomics identify ...
Lidan Hu, Xiaoyang Zhao, Yingxian Zhang, Jingjing Wang, Guozhen Wang, Xiaoli Liu, Zhan Feng, Jiazhen Yin, Zhaoyang Peng, Langping Gao, Jianhua Mao, Ning Shen   +11 more
wiley   +1 more source

Dynamic expression of lamin B1 during adult neurogenesis in the vertebrate brain

Developmental Dynamics, Volume 255, Issue 2, Page 187-208, February 2026.
Abstract Background In mammals, specific brain regions such as the dentate gyrus (DG) of the hippocampus and the subventricular zone (SVZ) of the lateral ventricles harbor adult neural stem/progenitor cells (ANSPCs) that give rise to new neurons and contribute to structural and functional brain plasticity.
Diana Zhilina, Lizbeth A. Bolaños Castro, Juan Sebastian Eguiguren, Sara Zocher, Anne Karasinsky, Dimitri Widmer, Alexandre Espinós, Victor Borrell, Michael Brand, Kyoko Miura, Oliver Zierau, Maximina H. Yun, Tomohisa Toda   +12 more
wiley   +1 more source