Results 61 to 70 of about 3,036 (198)
Advanced Functional Materials, Volume 35, Issue 38, September 18, 2025.Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim +8 more
wiley +1 more source
Targeted Regulation of Nuclear Lamins by Ubiquitin and Ubiquitin-Like Modifiers
Cells, 2020 Nuclear lamins (NLs) are essential components of the animal cell nucleus involved in the regulation of a plethora of molecular and cellular processes.
Michael Blank
doaj +1 more source
Cardiac involvement in laminopathies [PDF]
Orphanet Journal of Rare Diseases, 2015 Lamin A/C gene mutations can be associated with myocardial diseases, usually characterized by dilated cardiomyopathy and/or arrhythmic disorders. Phenotypic penetrance is age-related but expression is extremely heterogeneous, so that muscular and arrhythmic disease can be present in combination in the same patient, or one phenotypic manifestation can ...
Boriani, Giuseppe +3 more
openaire +1 more source
Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies
European Journal of Histochemistry, 2009 The involvement of the nuclear envelope in the modulation of chromatin organization is strongly suggested by the increasing number of human diseases due to mutations of nuclear envelope proteins.
NM Maraldi +6 more
doaj +1 more source
Aging and Altered Gravity: A Cellular Perspective
The FASEB Journal, Volume 39, Issue 13, 15 July 2025.We propose that, unlike biological aging, where Primary hallmarks initiate damage, spaceflight may trigger a feedback loop between Antagonistic and Integrative hallmarks, driving accelerated aging. Returning to 1 g restores proper signaling and breaks the cycle.
Sharon van Rijthoven +1 more
wiley +1 more source
Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture
Advanced Science, Volume 12, Issue 28, July 24, 2025.This study uses experiments and biophysical modeling to examine the response and adaptation of cells to nanoscale topography of surfaces. It is shown that cytoskeletal assembly and nuclear localization of transcription regulatory factors such as yes‐associated protein (YAP) and transcriptional coactivator with PDZ‐binding motif (TAZ) can be tuned by ...
Emmet A. Francis +7 more
wiley +1 more source
Identification of Genes and Pathways Regulated by Lamin A in Heart
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Mutations in the LMNA gene, encoding LMNA (lamin A/C), causes distinct disorders, including dilated cardiomyopathies, collectively referred to as laminopathies. The genes (coding and noncoding) and regulatory pathways controlled by LMNA in the
Jordi Coste Pradas +13 more
doaj +1 more source
Myonuclear alterations associated with exercise are independent of age in humans
The Journal of Physiology, Volume 603, Issue 13, Page 3755-3775, 1 July 2025.Abstract figure legend Structural and mechanical properties of myonuclei in trained young and aged individuals. In skeletal muscle fibres from trained individuals, myonuclei are more spherical, have greater lamin A and are stiffer compared to untrained counterparts.
E. Battey +15 more
wiley +1 more source
Nuclear Organization in Stress and Aging
Cells, 2019 The eukaryotic nucleus controls most cellular processes. It is isolated from the cytoplasm by the nuclear envelope, which plays a prominent role in the structural organization of the cell, including nucleocytoplasmic communication, chromatin positioning,
Raquel Romero-Bueno +4 more
doaj +1 more source